Abstract
The elimination of phenobarbitone (PB) was studied in 14 chronically treated epileptic patients under steady state conditions. PB, [S]-PB-N-glucoside ([S]-PB-N-G) and p-hydroxy-PB (p-OH-PB) were assayed in urine by a HPLC method.
Some 57 % of the daily dose was recovered in urine, 14 % as [S]-PB-N-G, 16 % as p-OH-PB (conjugated plus non-conjugated) and 27 % as unaltered PB.
Thus PB-N-G formation contributed significantly to the elimination of PB during long-term administration of the drug, and there was reason to suspect that some of the PB-N-G formed may have already been degraded to untraced products before excretion from the body.
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Bernus, I., Dickinson, R.G., Hooper, W.D. et al. Urinary excretion of phenobarbitone and its metabolites in chronically treated patients. Eur J Clin Pharmacol 46, 473–475 (1994). https://doi.org/10.1007/BF00191914
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DOI: https://doi.org/10.1007/BF00191914