Skip to main content

DNA binding and mutagenicity of lindane and its metabolites

This is a preview of subscription content, access via your institution.

References

  1. Ames BN, McCann J, Yamasaki E (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Res 31: 347–364

    Google Scholar 

  2. Bhatt B (1977) Studies on chromosomal aberrations in field workers spraying pesticides. Abstract, Second Annual Conference of Environmental Mutagen Society of India, Bombay

  3. Cabral JRP, Shubik P, Mollner T, Raitano F (1977) Carcinogenic activity of hexachlorobenzene in hamsters. Nature 269: 510–511

    Google Scholar 

  4. Chadwick RW, Copeland MF, Froehlich R, Cooke N (1983) Chlorobenzene-impaired metabolism and the effect of pretreatment with chlorobenzene, lindane or chlorobenzene plus lindane. J Toxicol Environ Health 12:559–610

    Google Scholar 

  5. Decloitre F, Chauveau J, Benoit A, Martin M (1975) Metabolisation et fixation in vitro par le DNA de thymus de veau et les proteines microsomiques de foie de rat de quelques pesticides organochlores et organophosphores. C R Acad Sci Paris, Ser D, 280: 1027–1030

    Google Scholar 

  6. Gopalaswamy UV, Aiyar AS (1984) Effects of lindane on liver mitochondrial function in the rat. Bull Environ Contam Toxicol 33: 106–113

    Google Scholar 

  7. Gopalaswamy UV, Aiyar AS (1988) Biotransformation and toxicity of lindane and its metabolite hexachlorobenzene in mammals. In Hexachlorobenzene: Proceedings of an International Symposium, Morris CR and Cabral JRP Eds. IARC Scientific Publications No.77, Lyon: 267–276

  8. Grover PL, Sims P (1965) The metabolism of gamma-2,3,4,5,6-pentachlorocyclo-hex-1-ene and gamma-hexachlorocyclohexane in rats. Biochem J 96: 521–525

    Google Scholar 

  9. Iverson F, Ryan JJ, Lizotte R, Hierlihy SL (1984) In vivo and in vitro binding of alpha and gamma-hexachlorocyclohexane to mouse liver macromolecules. Toxicol Lett 20: 331–335

    Google Scholar 

  10. Khera KS (1974) Teratogenicity and dominant lethal studies on hexachlorobenzene in rats. Food Toxicol 12: 471–477

    Google Scholar 

  11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275

    CAS  PubMed  Google Scholar 

  12. Lutz WK (1986) Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens. J Canc Res Clin Oncol 112: 85–91

    Google Scholar 

  13. Macholz RM, Kujawa M (1985) Recent state of lindane metabolism. Part III Residue Rev 94: 119–149

    Google Scholar 

  14. Marmur J (1961) A procedure for the isolation of DNA from microorganisms. J Molec Biol 3: 208–218

    Google Scholar 

  15. Masini A, Stanzani DC, Tomasi A, Trenti T, Ventura E (1985) The role of pentachlorophenol in causing mitochondrial derangement in hexachlorobenzene induced experimental porphyria. Biochem Pharmacol 34: 1171–1174

    Google Scholar 

  16. Metcalf RL (1955) Organic insectisides. Interscience, Wiley, New York

    Google Scholar 

  17. Oesch F, Fridberg T, Herbst M, Paul W, Wilhelm N, Bentley P (1982) Effects of lindane treatment on drug metabolising enzymes and liver weight of CFI mice in which it evoked hepatomas and in nonsusceptible rodents. Chem Biol Interact 40: 1–14

    Google Scholar 

  18. Reuber MD (1979) Carcinogenicity of lindane. Environ Res 1: 460–481

    Google Scholar 

  19. Sagelsdorff P, Lutz WK, Schlatter C (1983) The relevance of covalent binding to mouse liver DNA to the carcinogenic action of hexachlorocyclohexane isomers. Carcinogenesis 4: 1267–1273

    Google Scholar 

  20. Shah GM, Bhattacharya RK (1982) In vivo effect of l-ascorbic acid on benzo(a)pyrene metabolite — DNA adduct formation in rat liver. J Bioscience 4: 263–268

    Google Scholar 

  21. Wright AS, Ahintonwa DA, Wooder MF (1977) Studies on interactions of dieldrin with mammalian liver cells at the subcellular level. Ecotox Environ Safety 1: 7–16.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to C. K. K. Nair.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gopalaswamy, U.V., Nair, C.K.K. DNA binding and mutagenicity of lindane and its metabolites. Bull. Environ. Contam. Toxicol. 49, 300–305 (1992). https://doi.org/10.1007/BF00191771

Download citation

Keywords

  • Waste Water
  • Water Management
  • Water Pollution
  • Lindane