Summary
Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-β1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-β1 by molecular and immunohistochemical analysis in the developing mouse prostate. Accumulations of TGF-β1 protein were localized in the mesenchyme surrounding ductules in fetal and neonatal prostate. Previous studies in the mouse prostate reconstitution (MPR) model system have localized accumulations of TGF-β1 to regions of oncogene-induced abnormalities. In surgically excised adult human prostate tissues, localized accumulations of TGF-β1 are associated with prostate cancer and benign prostatic hyperplasia (BPH). Intracellular TGF-β1 was more often associated with stromal cells in BPH and with neoplastic epithelial cells in prostate cancer. The production and accumulation of TGF-β1 appears to involve interactions between mesenchymal and epithelial cells. Further experimental studies may clarify the relationships between TGF-β1 and abnormal prostatic growth.
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Timme, T.L., Yang, G., Truong, L.D. et al. Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities. World J Urol 13, 324–328 (1995). https://doi.org/10.1007/BF00191212
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DOI: https://doi.org/10.1007/BF00191212