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Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection

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Abstract

A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV) infection initially responded to treatment with interleukin-2 (IL-2). Six months later he developed thrombosis in the hepatic veins, and Budd-Chiari syndrome associated with severe hepatic damage was diagnosed. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 therapy, the possibility that long-term IL-2 therapy might cause Budd-Chiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.

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Abbreviations

EBV:

Epstein-Barr virus

EBER1:

EpsteinBarr virus-encoded RNA-1

IL-2:

interleukin-2

NK:

natural killer

LMP:

latent membrane protein

LAK:

lymphokine activated killer

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Authors and Affiliations

  1. First Department of Internal Medicine, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    S. Nagafuchi, H. Ishibashi, K. Anzai, Y. Ohno, N. Fukushima & Y. Niho

  2. Department of Pathology, School of Medicine, Fukuoka University, 814, Fukuoka, Japan

    K. Ohshima & M. Kikuchi

  3. Second Department of Surgery, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    M. Hashizume & K. Sugimachi

  4. Department of Orthopedics, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    H. Chuman

Authors
  1. S. Nagafuchi
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  2. H. Ishibashi
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  3. K. Anzai
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  4. K. Ohshima
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  5. Y. Ohno
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  6. N. Fukushima
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  7. M. Hashizume
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  8. K. Sugimachi
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  9. H. Chuman
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  10. M. Kikuchi
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  11. Y. Niho
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Nagafuchi, S., Ishibashi, H., Anzai, K. et al. Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection. Clin Investig 72, 883–886 (1994). https://doi.org/10.1007/BF00190746

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  • DOI: https://doi.org/10.1007/BF00190746

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