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Tubular injury in human kidneys: pathologic findings and pathogenic mechanisms

  • Guest Lectures, “Gessellschaft für Nephrologie”, 24th Congress
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References

  1. Arends MJ, Morris RG, Wyllie AH (1990) Apoptosis. The role of the endonuclease. Am J Pathol 136:543–608

    Google Scholar 

  2. Bacallao R, Mandel L (1991) Internalization of E-cadherin and Na-K ATPase in cultured renal cells occurs rapidly with energy depletion. J Am Soc Nephrol 2:643

    Google Scholar 

  3. Bonventre JV (1988) Mediators of ischemic renal injury. Annu Rev Med 39:531–544

    Google Scholar 

  4. Bonventre JV (1993) Mechanisms of ischemic acute renal failure. Kidney Int 43:1160–1178

    Google Scholar 

  5. Borkan SC, Schwartz JH (1989) Role of oxygen free radical species in in vitro models of proximal tubule ischemia. Am J Physiol 257:F114-F125

    Google Scholar 

  6. Gailit J, Colflesh D, Rabinder I, Simone J, Goligorsky MS (1993) Redistribution and dysfunction of intergrins in cultured renal epithelial cells exposed to oxidative stress. Am J Physiol 264:F149-F157

    Google Scholar 

  7. Gobe GC, Axelsen RA, Searle JW (1990) Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy. Lab Invest 63:770–779

    Google Scholar 

  8. Goligorsky MS, DiBona GF (1993) Proc Natl Acad Science USA 90 (in press)

  9. Graber M, Lane B, Lamina R, Pastoriza-Munoz E (1991) Bubble cells: renal tubular cells in the urinary sediment with characteristics of viability. J Am Soc Nehprol 1:999–10 004

    Google Scholar 

  10. Humes HD (1986) Role of calcium in pathogenesis of acute renal failure. Am J Physiol 250:F579-F589

    Google Scholar 

  11. Jacobs WR, Sgambati M, Gormez G, Vilaro P, Higdon M, Bell PD, Mandel LJ (1991) Role of cytosolic Ca in renal tubule damage induced by anoxia. Am J Physiol 260:C545-C554

    Google Scholar 

  12. Kroshian VM, Lieberthal W (1991) Sublethal injury induced by ATP depletion impairs cell adhesion in mouse proximal tubular cells. J Am Soc Nephrol 2:649

    Google Scholar 

  13. Mandel L, Bacallao R (1991) Alterations in the cytoskeleton and transepithelial resistance during ATP depletion in cultured renal epithelial cells. J Am Soc Nephrol 2:651

    Google Scholar 

  14. Olsen S, Burdick JF, Keown PA, Wallace AC, Racusen LC, Solez K (1989) Primary acute renal failure (“acute tubular necrosis”) in the transplanted kidney: morphology and pathogenesis. Medicine 68:173–187

    Google Scholar 

  15. Paller MS (1985) Free radical scavengers in mercuric chloride-induced acute renal failure in the rat. J Lab Clin Med 105:459–463

    Google Scholar 

  16. Paller MS, Neumann TV (1991) Reactive oxygen species and rat renal epithelial cells during hypoxia and reoxygenation. Kidney Int 40:1041–1049

    Google Scholar 

  17. Portilla D, Mandel LJ, Bar-Sagi D, Millington DS (1992) Anoxia induces phospholipase A2 activiation in rabbit renal proximal tubule. Am J Physiol 262:F354–362

    Google Scholar 

  18. Racusen LC (1990) Anoxia-induced shape changes in cultured human renal proximal tubular cells — role of microfilaments. J Am Soc Nephrol 1:602

    Google Scholar 

  19. Racusen LC (1991) Structural correlates of renal electrolyte alterations in acute renal failure. Miner Electrolyte Metab 17:72–88

    Google Scholar 

  20. Racusen L (1992) Alterations in tubular epithelial cell adhesion and mechanisms of acute renal failure. Lab Invest 67:158–165

    Google Scholar 

  21. Racusen LC, Fivush BA, Li Y-L, Slatnik I, Solez K (1991) Dissociation of tubular cell detachment and tubular cell death in clinical and experimental “acute tubular necrosis.” Lab Invest 64:546–556

    Google Scholar 

  22. Schumer KM, Olsen CA, Wise GJ, Buttyan R (1992) Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 140:831–838

    Google Scholar 

  23. Schwertz D, Kreisberg JI, Venkatachalam MA (1984) Effects of aminoglycosides on proximal tubule brush border membrane phosphatidylinositol-specific phospholipid C. J Pharmacol Exp Ther 231:48–55

    Google Scholar 

  24. Segasothy M, Fairly KF, Birch DF, Kincaid-Smith P (1989) Immunoperoxidase identification of nucleated cells in urine in glomerular and acute tubular disorders. Clin Nephrol 31:281–291

    Google Scholar 

  25. Shah SV, Walker PD (1988) Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol F438–F443

  26. Smith MW, Ambudkar IS, Phelps PC, Regec AL, Trump BF (1987) Hg-Cl2-induced changes in cytosolic Ca2+ in cultured rabbit renal tubule cells. Biochim Biophys Acta 931:130–142

    Google Scholar 

  27. Solez K, Morel-Maroger L, Sraer J-D (1979) The morphology of “acute tubular necrosis” in man: analysis of 57 renal biopsies and a comparison with the glycerol model. Medicine 58:362–376

    Google Scholar 

  28. Troyer DA, Kreisberg JI, Venkatachalam MA (1986) Lipid alterations in LLC-PKI cells exposed to mercuric chloride. Kidney Int 29:530–538

    Google Scholar 

  29. Wyllie AH, Morris RG, Smith AL, Dunlop D (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol 142:67–77

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology School of Medicine, Johns Hopkins University, Ross Research Building 720 Rutland Avenue, Room 624, 21205-2196, Baltimore, MD, USA

    L. C. Racusen

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  1. L. C. Racusen
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Racusen, L.C. Tubular injury in human kidneys: pathologic findings and pathogenic mechanisms. Clin Investig 71, 858–860 (1993). https://doi.org/10.1007/BF00190338

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