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Repeated complete remission in a patient with acute promyelocytic leukemia after treatment with 13-cis-retinoic acid first and with all-trans-retinoic acid in relapse

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Summary

The use of retinoic acid is a new approach in the treatment of acute promyelocytic leukemia. We outline the therapy in a 61-year-old patient with acute promyelocytic leukemia who had not responded to standard chemotherapy but in whom the administration of 13-cis-retinoic acid resulted in complete remission for 24 months. In relapse the patient was treated with all-trans-retinoic acid in combination with two cycles of daunorubicin and cytosine arabinoside and achieved another complete remission.

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Author notes

  1. T. Haferlach

    Present address: II. Medizinische Klinik, Christian-Albrechts-Universität Kiel, Chemnitzstrasse 33, D-24116, Kiel, Germany

Authors and Affiliations

  1. II. Medizinische Klinik, Christian-Albrechts-Universität Kiel, Germany

    T. Haferlach, H. Löffler, B. Glass & W. Gassmann

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Haferlach, T., Löffler, H., Glass, B. et al. Repeated complete remission in a patient with acute promyelocytic leukemia after treatment with 13-cis-retinoic acid first and with all-trans-retinoic acid in relapse. Clin Investig 71, 774–779 (1993). https://doi.org/10.1007/BF00190317

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