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Notes on the pathogenesis of enterovirus infections

Observations, experiments, and speculations

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Abstract

Despite extensive investigations over the last decades, several aspects of the pathogenesis of enterovirus infections in humans and animals are only poorly understood, such as the molecular basis of virulence (in particular of neurovirulence), tissue tropisms (e. g. the precise site of initial virus replication in the human intestinal tract), and precipitating factors of paralytic disease (“disposition”). Studies on poliovirus myocarditis in man are reviewed. Unequivocal evidence on replication of poliovirus type 2 (strains MEF1 and Lansing) in newborn and suckling mice and on poliovirus myocarditis is presented. Our observations strengthen the thesis of similar pathogenic potentials of the enterovirus group.

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  1. Institut für Virologie der Universität zu Köln, Fürst-Pückler-Strasse 56, 41, Köln, Federal Republic of Germany

    Hans J. Eggers

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Eggers, H.J. Notes on the pathogenesis of enterovirus infections. Med Microbiol Immunol 179, 297–306 (1990). https://doi.org/10.1007/BF00189608

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