, Volume 39, Issue 5, pp 355–358 | Cite as

Structure and polymorphism of horse MHC class II DRB genes: convergent evolution in the antigen binding site

  • Kenth Gustafsson
  • Leif Andersson
Brief Communications


Binding Site Convergent Evolution Antigen Binding Antigen Binding Site 
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  1. Andersson, G., Larhammar, D., Widmark, E., Servenius, B., Peterson, P. A., and Rask, L. Class II genes of the human major histocompatibility complex: organization and evolutionary relationship of the DRß genes. J Biol Chem 262: 8748–8758, 1987Google Scholar
  2. Andersson, L., Sigurdardottir, S., Borsch, C., and Gustafsson, K. Evolution of MHC polymorphism: extensive sharing of polymorphic sequence motifs between human and bovine DRB alleles. Immunogenetics 33: 188–193, 1991Google Scholar
  3. Bell, J. I., Estess, P., St. John, Saiki, R., Watling, D. L., Ehrlich, H. A., and McDevitt, H. O. DNA sequence and characterization of human class II major histocompatibility complex \gB chains from the DR1 haplotype. Proc Natl Acad Sci USA 82: 3405–3409, 1985Google Scholar
  4. Bell, J. I., Denney, D. J., Foster, L., Belt, T., Todd, J. A., and McDevitt, H. O. Allelic variation in the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci USA 84: 6234–6238, 1987Google Scholar
  5. Denaro, M., Hammerling, U., Rask, L., and Peterson, P. A. The Ebß gene may have acted as the donor gene in a gene conversion-like event generating the Abm12ß mutant. EMBO J 7: 3745–3753, 1984Google Scholar
  6. Gustafsson, K., Wiman, K., Emmoth, E., Larhammar, D., Böhme, J., Hyldig-Nielsen, J. J., Ronne, H., Peterson, P. A., and Rask, L. Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J 3: 1655–1661, 1984Google Scholar
  7. Gustafsson, K., Germana, S., Hirsch, F., Pratt, K., LeGuern, C., and Sachs, D. H. Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related species. Proc Natl Acad Sci USA 87: 9798–9802, 1990Google Scholar
  8. Lundberg, A. S. and McDevitt, H. O. Evolution of major histocompatibility complex class II diversity: direct descent in mice and humans. Proc Natl Acad Sci USA 89: 6545–6549, 1992Google Scholar
  9. Marsh, S. G. E. and Bodmer, J. G. HLA class II nucleotide sequences, 1992. Eur J Immunogenetics 20: 47–79, 1993Google Scholar
  10. Mengle-Gaw, L. and McDevitt, H. O. Predicted protein sequence of the murine I-EßS polypeptide chain from cDNA and genomic clones. Proc Natl Acad Sci USA 82: 2910–2914, 1983Google Scholar
  11. Robertson, K. A. and McMaster, W. R. Complete structure of a rat RT1 Eß chain: extensive conservation of MHC class II \gB chains. J Immunol 135: 4095–4099, 1985Google Scholar
  12. Sarmiento, U. M., Sarmiento, J. I., and Storb, R. Allelic variation in the DR subregion of the canine major histocompatibility complex. Immunogenetics 32: 13–19, 1990Google Scholar
  13. Sigurdardottir, S., Borsch, C., Gustafsson, K., and Andersson, L. Cloning and sequence analysis of 14 DRB1 alleles of the bovine MHC by using the polymerase chain reaction. Anim Genet 22: 199–209, 1991Google Scholar
  14. Spies, T., Sorrentino, R., Boss, J. M., Okada, K., and Strominger, J. L. Structural organization of the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci USA 82: 5165–5169, 1985Google Scholar
  15. Tonnelle, C., DeMars, R., and Long, E. O. DOß: a new β chain gene in HLA-D with a distinct regulation of expression. EMBO J 4: 2839–2847, 1985Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Kenth Gustafsson
    • 1
  • Leif Andersson
    • 2
  1. 1.Department of Medical and Physiological ChemistryUppsala University, Biomedical CentreUppsalaSweden
  2. 2.Department of Animal Breeding and GeneticsSwedish University of Agricultural Sciences, Genetic CentreUppsalaSweden

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