Abstract
A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.
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D'Alfonso, S., Cappello, N., Borelli, I. et al. HLA supratypes in an Italian population. Immunogenetics 39, 114–120 (1994). https://doi.org/10.1007/BF00188614
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DOI: https://doi.org/10.1007/BF00188614