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Palliation for pancreatic cancer

Feasibility of laparoscopic cholecystojejunostomy and gastrojejunostomy in a porcine model

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Abstract

Background: Although laparoscopy reveals undetected metastases in many patients with pancreatic cancer, most surgeons have chosen to proceed directly with laparotomy in an attempt at resection or for palliation of biliary and gastric outlet obstruction. In an effort to overcome this limitation, this study attempted to determine the feasibility of laparoscopic cholecystojejunostomy and gastrojejunostomy.

Methods: Under general anesthesia, seven pigs underwent laparoscopic cholecystojejunostomy and gastrojejunostomy using either a hand-sutured or the stapled/sutured technique.

Results: Mean operating time was less with the stapled/sutured vs hand-sutured technique (150±21 vs 230±13 min, P<0.05). All animals recovered completely and there was no change in their weight or liver function tests as a result of the procedure. At sacrifice, all anastomoses were patent, although some were significantly narrowed in these unobstructed animals.

Conclusions: These results suggest that simultaneous laparoscopic palliation of biliary and gastric outlet obstruction is feasible. We believe these results warrant further study in the clinical setting.

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References

  1. Cotton PB (1989) Nonsurgical palliation of jaundice in pancreatic cancer. Surg Clin North Am 69: 613–627

    Google Scholar 

  2. Fontham E, Correa P, Cohn I Jr (1990) Epidemiology of cancer of the pancreas. In: Howard JM, Jordan GL, Reber HA (eds) Surgical diseases of the pancreas. Lea & Febiger, Philadelphia, pp 613–626

    Google Scholar 

  3. Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of advanced pancreatic cancer. Cancer 59: 2006–2010

    Google Scholar 

  4. Gastrointestinal Tumor Study Group (1988) Treatment of locally unresectable carcinoma of the pancreas. Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 80: 751–755

    Google Scholar 

  5. Rangraj MS, Metha M, Zale G, Maffucci L, Herz B (1994) Laparoscopic gastrojejunostomy: a case presentation. J Laparoendosc Surg 4: 81–7

    Google Scholar 

  6. Rhodes M, Nathanson L, Fielding G (1995) Laparoscopic biliary and gastric bypass: a useful adjunct in the treatment of carcinoma of the pancreas. Gut 36: 778–780

    Google Scholar 

  7. Schob O, Schmid R, Schlumpf R, Largiader F (1994) Laparoscopic Y-Roux anastomosis. Helv Chir Acta 60: 1001–6

    Google Scholar 

  8. Shimi S, Banting S, Cuschieri A (1992) Laparoscopy in the management of pancreatic cancer: endoscopic cholecystojejunostomy for advanced disease. Br J Surg 79: 317–319

    Google Scholar 

  9. Silverberg E, Boring CC, Squires TS (1990) Cancer statistics, 1990. CA 40: 9–26

    Google Scholar 

  10. Singh SM, Reber HA (1989) Surgical palliation for pancreatic cancer. Surg Clin N Am 69: 599–611

    Google Scholar 

  11. Singh SM, Longmire WP Jr, Reber HA (1990) Surgical palliation for pancreatic cancer. The UCLA experience. Ann Surg 212: 132–139

    Google Scholar 

  12. Warshaw AL, Tepper JE, Shipley WU (1986) Laparoscopy in the staging and planning of therapy for pancreatic cancer. Am J Surg 158: 76–80

    Google Scholar 

  13. Warshaw AL, Swanson RS (1988) Pancreatic cancer in 1988. Possibilities and probabilities. Ann Surg 208: 541–553

    Google Scholar 

  14. Warshaw AL, Gu GY, Wittenberg J, Waxman AC (1990) Preoperative staging and assessment of resectability of pancreatic cancer. Arch Surg 125: 230–233

    Google Scholar 

  15. Watanapa P, Williamson RCN (1992) Surgical palliation for pancreatic cancer: developments during the past two decades. Br J Surg 79: 8–20

    Google Scholar 

Download references

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Patel, A.G., McFadden, D.W., Hines, O.J. et al. Palliation for pancreatic cancer. Surg Endosc 10, 639–643 (1996). https://doi.org/10.1007/BF00188518

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  • DOI: https://doi.org/10.1007/BF00188518

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