Skip to main content

Advertisement

Log in

Zur therapie der Ösophagusvarizenblutung in der Bundesrepublik Deutschland (West) — Ergebnisse einer Urnfrage

Therapy of esophageal variceal bleeding in West Germany

  • Published:
Langenbecks Archiv für Chirurgie Aims and scope Submit manuscript

Summary

An inquiry concerning bleeding of esophageal varices included 1076 surgical and medical departments in the Federal Republic of Germany (West). Prevailing forms of treatment are acute sclerotherapy or esophageal balloon tamponade followed by long-term sclerotherapy. In case of medically uncontrollable bleeding oesophagogastric devascularization procedures are preferred to portacaval shunt. Beta-blockers are applied in medical departments for the prophylaxis of recurrence. Only after several rebleedings, despite of sclerotherapy, approx. half of the departments consider an elective shunt. The distal splenorenal shunt described by Warren and portacaval anastomosis clearly prevail over all other shunts.

Zusammenfassung

An 1076 chirurgischen und internistischen Abteilung in der BRD (West) wurde eine Umfrage zur Behandlung der Ösophagusvarizenblutung durchgeführt. Es überwiegt die Akutsklerosierung bzw. die Ballonsondenbehandlung mit nachfolgender Sklerosierung bei der aktiven Blutung. Die abdominelle Sperroperation wird bei der konservativ nicht stillbaren Blutung noch vor dem portokavalen Notshunt bevorzugt. Betablocker werden vor allem in internistischen Abteilungen zur Rezidivprophylaxe eingesetzt. Erst nach mehrfacher Rezidivblutung trotz Sklerosierung sehen etwa die Hälfte der Abteilungen eine Indikation zum elektiven Shunt. Der distale splenorenale Shunt nach Warren and die portokavale Anastomose dominieren deutlich gegenüber den anderen Shuntformen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  1. Barsoum MS, Bolous FI, El-Rooby AA, Rizk-Allah Ibrahim AS (1982) Tamponade and injection sclerotherapy in the management of bleeding oesophageal varices. Br J Surg 69:76–78

    Google Scholar 

  2. Burroughs AK, Jenkins WJ, Sherlock S, Dunk A, Walt RP, Osuafor TOK, Mackie S, Dick R (1983) Controlled trial of propanolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis N Engl J Med 309:1539–1542

    Google Scholar 

  3. Burroughs AK (1988) The management of bleeding due to portal hypertension. Part. 1. The management of acute bleeding episode. Q J Med 67:447–458

    Google Scholar 

  4. Burroughs AK, Hamilton G, Phillips A, Mezzanotte G, McIntyre N, Hobbs KEF (1989) A comparison of sclerotherapy with staple transection of the esophagus for the emergency control of bleeding from esophageal varices. N Engl J Med 321:857–862

    Google Scholar 

  5. Cello JP, Grendell JH, Crass RA, Weber TE, Trunkey DD (1987) Endoscopic sclerotherapy versus portacaval shunt in patients with severe cirrhosis and acute variceal hemorrhage. Long-term follow-up. N Engl J Med 316:11–15

    Google Scholar 

  6. Chaudhary A, Tatke M, Aranya RC (1990) Endoscopic sclerotherapy: the far and near effects. Br J Surg 77:963

    Google Scholar 

  7. Cohen FL, Koerner RS, Taub SJ (1985) Solitary brain abscess following endoscopic injection sclerosis of esophageal varices. Gastrointest Endosc 31:331–333

    Google Scholar 

  8. Colombo M, de Franchis R, Tommasini M, Sangiovanni A, Dioguardi N (1989) β-blockade prevents recurrent gastrointestinal bleeding in well-compensated patients with alcoholic cirrhosis. A multicenter randomized controlled trial. Hepatology 9:433–438

    Google Scholar 

  9. Fleig WE, Stange EF, Hunecke R, Schönborn W, Hurler U, Rainer K, Gans W, Ditschuneit H (1987) Prevention of recurrent bleeding in cirrhotics with recent variceal hemorrhage: prospective randomized comparison of propanolol and sclerotherapy. Hepatology 7:355–361

    Google Scholar 

  10. Fischer JE, Bower RH, Atamian S, Welling R (1981) Comparison of distal and proximal splenorenal shunts. A randomized prospective trial. Ann Surg 194:531–544

    Google Scholar 

  11. Grace ND, Conn HO, Resnick RH, Groszmann RJ, Atterbury CE, Wright SC, Gusberg RJ, Vollmann R, Gardia-Tsao G, Fisher RL, O'Hara ET, McDermott WV, Maselli JP, Widrich W, Matloff DS, Horst D, Banks N, Alberts J (1988) Distal splenorenal shunt versus portalsystemic shunts after hemorrhage from varices: a randomized controlled trial. Hepatology 8:1475–1481

    Google Scholar 

  12. Harley HAJ, Morgan T, Redeker AG, Eynolds TB, Villamil F, Weiner JM, Yellin A (1986) Results of a randomized trial of end-to-side portacaval shunt and distal splenorenal shunt in alcoholic liver disease and variceal bleeding. Gastroenterology 91:802–809

    Google Scholar 

  13. Häring R, Karavias Th (1990) Oesophagusvaricenblutung: Therapiekonzepte und Ergebnisse. Chirurg 61:213–221

    Google Scholar 

  14. Henderson JM, Milikan WJ, Wright-Bacon L, Kutner MH, Warren WD (1983) Hemodynamic differences between alcoholic and nonalcoholic cirrhotics following distal splenorenal shunt-effect on survival? Ann Surg 198:325–334

    Google Scholar 

  15. Huizinga WKJ, Angorn PA, Baker WW (1985) Oesophageal transection versus injection sclerotherapy in the management of bleeding esophageal varices in patients at high risk. Surg Gynecol Obstet 160:539–546

    Google Scholar 

  16. Hunter GC, Steinkirchner T, Burbige EJ, Guernsey JM, Putnam CW (1988) Venous complications of sclerotherapy for esophageal varices. Am J Surg 157:497–501

    Google Scholar 

  17. Keagy BA, Schwartz JA, Johnson G (1986) Should ablative operations be used for bleeding esophageal varices. Ann Surg 203:464–469

    Google Scholar 

  18. Kemmel van M (1974) Resection anastomose de l'oesophage sus cardial pour rupture de varices oesophagiennes. Nouv Presse Med 5:1123–1124

    Google Scholar 

  19. Kobe E, Schentke K-U (1987) Unsichere Rezidivprophylaxe von Ösophagusvarizenblutungen durch Propanolol bei Leberzirrhotikern — eine prospektive kontrollierte Studie. Z Klin Med 42:507–510

    Google Scholar 

  20. Korula J, Balart LA, Radvan G, Zweiban BE, Larson AW, Kao HW, Yamada S (1985) A prospective, randomized trial of chronic esophageal variceal sclerotherapy. Hepatology 5: 584–589

    Google Scholar 

  21. Langer B, Taylor BR, Mackenzie DR, Gilas T, Stone RM, Blendis L (1985) Further report of a prospective randomized trial comparing distal splenorenal shunt with end-to-side porta caval shunt. An analysis of encephalopathy, survival and quality of life. Gastroenterology 88:424–429

    Google Scholar 

  22. Lebrec D, Poynard T, Bernuau J, Bercoff E, Nouel O, Capron JP, Poupon R, Bouvry M, Rueff B, Benhamou JP (1984) A randomized controlled study of propanolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a final report. Hepatology 4:355–358

    Google Scholar 

  23. MacDougall BRD, Westaby D, Theodossi A, Dawson JL, Williams R (1982) Increased long-term survival in variceal hemorrhage using injection sccerotherapy. Lancet 1:124–127

    Google Scholar 

  24. Malt RA, Abott WM, Warshaw AL, Salm TJ, Smead WL (1978) Randomized trial of emergency mesocaval and portacaval shunts for bleeding esophageal varices. Am J Surg 135:584–588

    Google Scholar 

  25. Ng WD, Chan YT (1988) Digital gangrene complicating intraoperative injection sclerotherapy. Gastrointest Endosc 34:151–153

    Google Scholar 

  26. O'Grady JG, Williams R (1988) Present position of liver transplantation and its impact on hepatological practice. Gut 29: 566–570

    Google Scholar 

  27. Orloff MJ, Bell RH, Greenburg AG (1986) Prospective randomised trial of emergency portacaval shunt and medical therapy in unselected cirrhotic patients with bleeding varices. Gastroenterology 90:1754

    Google Scholar 

  28. Paquet K-J, Feussner H (1985) Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophagogastric varices: a prospective controlled randomized trial. Hepatology 5:580–583

    Google Scholar 

  29. Pichlmayr R (1988) Derzeitige Indikationen zur Nieren-, Pankreas- und Lebertransplantation. Chirurg 59:454–458

    Google Scholar 

  30. Queuniet AM, Czernichow P, Lerebours E, Ducrotte P, Tranvouez JL, Colin R (1987) Etude controlée du propanolol dans la prevention des récidives hémorragiques chez les patients cirrhotiques. Gastroenterol Clin Biol 11:41–47

    Google Scholar 

  31. Reichle RA, Fahmy WF, Colsorkhi M (1979) Prospective comparative clinical trial with distal splenorenal and mesocaval shunts. Am J Surg 137:13–21

    Google Scholar 

  32. Rikkers LF, Rudman D, Galambos JT, Fulenwider JT, Milikan WJ, Kutner M, Smith RB III, Jones PJ Jr, Salam AA, Warren WD (1978) A randomized, controlled trial of the distal splenorenal shunt. Ann Surg 188:271–282

    Google Scholar 

  33. Rikkers LF, Burnett DA, Volentine GD, Buchi KN, Cormier RA (1987) Shunt surgery versus endoscopic sclerotherapy for long term treatment of variceal bleeding. Ann Surg 206: 261–271

    Google Scholar 

  34. Rinecker H, Danek N (1975) Operative Behandlung blutender Oesophagusvaricen durch eine subkardiale Blutsperre mittels transmuraler maschineller Klammerung. Chirurg 46:87–90

    Google Scholar 

  35. Rössle M, Richter GM, Noeldge G, Siegerstetter V, Palmaz JC, Wenz W, Gerok W (1989) Der intrahepatische portosystemische Shunt. Dtsch Med Woehenschr 114:1511–1516

    Google Scholar 

  36. Sauerbruch T (1990) Therapie der Osophagusvarizenblutung. Leber Magen Darm 1/90:11–19

    Google Scholar 

  37. Söderlund C, Ihre T (1985) Endoscopic sclerotherapy vs. conservative management of bleeding oesophageal varices. Acta Chir Scand 151:449–456

    Google Scholar 

  38. Söderlund C (1987) Long-term survivors after variceal hemorrhage. Follow-up of a controlled study of endoscopic sclerotherapy versus conservative management. Scand J Gastroenterol 22:665–671

    Google Scholar 

  39. Spina G, Santambrogio R, Opocher E, Galeotti F, Cuechiaro G, Strinna M, Pezzuoli G (1988) Improved quality of life after distal splenorenal shunt. Ann Surg 208:104–109

    Google Scholar 

  40. Schölmerich J, Holstege A (1990) Therapie der Osophagusvarizenblutung. Dtsch Arztebl 38(A):2803–2810

    Google Scholar 

  41. Steegmüller KW, Fischer R (1980) Der portocavale Notshunt bei der konservativ nicht stillbaren Oesophagusvaricenblutung Langenbecks Arch Chir 353:81–88

    Google Scholar 

  42. Steegmuller KW, Böttger Th, Junginger Th (1990) Zum Stellenwert drucksenkender Operationen bei der portalen Hypertension. Dtsch Med Wochenschr 115:589–594

    Google Scholar 

  43. Sugiura M, Futagawa S (1984) Esophageal transection with paraesophagogastric devascularizations (the Sugiura procedure) in the treatment of esophageal varices. World J Surg 8:673–682

    Google Scholar 

  44. Terblanche J, Bornman PC, Kahn D, Jonker MAT, Campbell JAH, Wright J, Kirsch R (1983) Failure of repeated injection sclerotherapy to improve long-term survival after oesophageal variceal bleeding. Lancet 11:1328–1332

    Google Scholar 

  45. Teres J, Baroni R, Bordas JM, Visa J, Pera C, Rodes J (1987) Randomized trial of portacaval shunt, stapling transection and endoscopic sclerotherapy in uncontrolled variceal bleeding. J Hepatol 4:159–167

    Google Scholar 

  46. Teres J, Bordas JM, Bravo D, Visa J, Grande L, Garcia-Valdecasas JC, Pera C, Rodes J (1987) Sclerotherapy versus distal splenorenal shunt in the elective treatment of variceal hemorrhage. A randomized controlled trial. Hepatology 7:430–436

    Google Scholar 

  47. Terpstra OT, Ausema B, Bruining HA, Lameris JS, Revers CB, Schalm SW, van Urk H, Wilson JHP (1987) Late results of mesocaval interposition shunting for bleeding oesophageal varices. Br J Surg 74:787–790

    Google Scholar 

  48. The Copenhagen esophageal varices sclerotherapy project (1984) Sclerotherapy after first variceal hemorrhage in cirrhosis. A randomized multicenter trial. N Engl J Med 311:1594–1600

    Google Scholar 

  49. Villeneuve JP, Pomier-Layrargues G, Infante-Rivard C, Willems B, Huet PM, Marleau D, Viallet A (1986) Propanolol for the prevention of recurrent variceal haemorrhage: a controlled trial Hepatology 6:1239–1243

    Google Scholar 

  50. Villeneuve JP, Pomier-Layrargues G, Duguay L, Lapointe R, Tanguay S, Marleau D, Willems B, Huet PM, Infanterivard C, Lavoie P (1987) Emergency portacaval shunt for variceal hemorrhage. Ann Surg 206:48–52

    Google Scholar 

  51. Warren WD, Galambos JT, Riepe SP, Henderson JM, Brooks WS, Salam AA, Milikan WJ, Kutner MH (1986) Distal splenorenal shunt versus endoscopic sclerotherapy for longterm management of variceal bleeding. Ann Surg 203:454–462

    Google Scholar 

  52. Westaby D, MacDougall BRD, Williams R (1985) Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. Hepatology 5:827–830

    Google Scholar 

  53. Westaby D, Hayes PC, Gimson AES, Poison RJ, Williams R (1989) Controlled clinical trial of injection sclerotherapy for active variceal bleeding. Hepatology 9:274–277

    Google Scholar 

  54. Westaby D, Melia W, Hegarty J, Gimson AES, Stellon AJ, Williams R (1986) Use of propanolol to reduce the rebleeding rate during injection sclerotherapy prior to variceal obliteration. Hepatology 6:673–675

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Steegmüller, K.W., Schmidt, D. & Junginger, T. Zur therapie der Ösophagusvarizenblutung in der Bundesrepublik Deutschland (West) — Ergebnisse einer Urnfrage. Langenbecks Arch Chir 376, 273–279 (1991). https://doi.org/10.1007/BF00188267

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00188267

Key words

Navigation