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European Radiology

, Volume 2, Issue 6, pp 536–541 | Cite as

Chemoembolisation of hepatocellular carcinomas: personal experience

  • G. C. Ettorre
  • A. P. Garribba
  • G. Francisco
  • F. Mirizzi
  • S. Elba
  • A. Mossa
  • F. Martino
Original Articles Gastrointestinal radiology
  • 21 Downloads

Abstract

Transcatheter arterial chemoembolisation (TACE) using antiblastic agents in association with occlusion of tumour-feeding arteries seems currently to be the most suitable treatment for unresectable hepatocellular carcinomas (HCC) larger than 3 cm in diameter. From July 1989 to January 1991, 21 patients with HCC and a previous history of liver cirrhosis were treated by TACE. The drugs used were doxorubicin and mitomycin C mixed with Lipiodol UF. The arterial occlusion was obtained using Gelfoam or Spongostan particles; in 16 patients it was limited to tumour-feeding arteries to avoid diffuse parenchymal liver damage, while in 5 patients either the main right or left hepatic artery was embolised. Three patients were excluded from the study after TACE because of too short a follow-up; 4/18 died within 3–9 months and 14/18 are still alive with follow-up ranging from 3 to 19 months. A tumour size reduction of more than 50% was observed in 9 patients (50%), with a median survival of 9.8 months. Transient and well-controlled side effects (fever, abdominal pain, nausea and vomiting) were related to the post-embolisation syndrome and could be reduced by using a superselective occlusion procedure.

Key words

Hepatocellular carcinoma (HCC) Liver cirrhosis Transcatheter arterial chemoembolisation (TACE) 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. C. Ettorre
    • 1
  • A. P. Garribba
    • 1
  • G. Francisco
    • 1
  • F. Mirizzi
    • 1
  • S. Elba
    • 2
  • A. Mossa
    • 1
  • F. Martino
    • 1
  1. 1.Istituto di Radiologia-PoliclinicoBariItaly
  2. 2.IRCCSCastellana GrotteItaly

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