Skip to main content
Log in

Defective monocyte chemotaxis in patients with epidermoid tumors of the head and neck

  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Summary

Monocyte chemotactic activity was assayed by a modified Boyden-Chamber method using the chemoattractant casein and was found to be impaired in 13 patients with epidermoid tumors of the head and neck. Using 7 healthy subjects as controls, the depression in both monocyte chemotactic activity and monocyte random migration in the patients with tumors was found to be statistically significant by the “leading front” technique (P < 0.05).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Balm AJM, Drexhage JA, Blomberg M, Snow GB (1982) Mononuclear phagocyte function in head and neck cancer: NBT-dye reduction, maturation and migration of peripheral blood monocytes. Laryngoscope 92:810–814

    Google Scholar 

  2. Balm AJM, Drexhage HA, Blomberg M, Weltevreden EF, Veldhuizen RW, Mullink R, Snow GB (1984) Mononuclear phagocyte function in head and neck cancer. Cancer 54: 1010–1015

    Google Scholar 

  3. Boyum A (1968) Isolation of leucocytes from human blood: further observations. Scand J Clin Lab Invest 21 [Suppl 97] 31–50

    Google Scholar 

  4. Boyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21 [Suppl 97] 77–89

    Google Scholar 

  5. Lichtenstein A, Zighelboim J, Dorey F, Brosman S, Fahey JL (1980) Comparison of immune derangements in patients with different malignancies. Cancer 45:2090–2095

    Google Scholar 

  6. Snyderman R, Pike MC (1977) Macrophage migratory dysfunction in cancer: a mechanism for subversion of surveillance. Am J Pathol 88: 727–739

    Google Scholar 

  7. Tan B, Drexhage HA, Scheper RJ, Blomberg BME, Haad Meulman M, Snow GB, Balm AJM (1986) Defective monocyte chemotaxis in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 112:541–544

    Google Scholar 

  8. Walter RJ, Danielson JR (1985) Defective monocyte chemotaxis in patients with epidermoid tumors of the head and neck. Arch Otolaryngol 111:538–540

    Google Scholar 

  9. Walter RJ, Danielson JR, Alten PJ, Powell WJ (1986) Defects in monocyte chemotaxis in patients with neoplastic disease. J Surg Res 41:215–224

    Google Scholar 

  10. Yam LT, Li CY, Crosby WH (1970) Cytochemical identification of monocytes. Am J Clin Pathol 55:283–290

    Google Scholar 

  11. Zigmond SH, Hirsch JG (1973) Leucocyte locomotion and chemotaxis. J Exp Med 137:387–410

    Google Scholar 

  12. Zigmond SH, Lauffenburger DA (1986) Assays of leucocyte chemotaxis. Annu Rev Med 37:149–155

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Güngör, A., Yetgin, S. & Sözeril, B. Defective monocyte chemotaxis in patients with epidermoid tumors of the head and neck. Eur Arch Otorhinolaryngol 250, 289–291 (1993). https://doi.org/10.1007/BF00186228

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00186228

Key words

Navigation