Summary
The granulosa cell tumour is a rare and malignant neoplasia of the ovary. As it has a low grade of malignancy a long course of the disease is observed. Following surgical resection, life-long tumour follow-up is recommended. Based on a case report and a review of the literature, the possible sites of metastases are demonstrated. This paper presents the latest therapeutic concepts and discusses the usefulness of metastasis resection.
Zusammenfassung
Der Granulosazelltumor ist eine seltene maligne Neoplasie des Ovars. Bei niedrigem Malignitätsgrad werden meist lange Verläufe beobachtet. Eine lebenslange Tumornachsorge ist sinnvoll. Anhand eines Fallberichts und der Literatur werden die möglichen Metastasenlokalisationen aufgezeigt. Die Arbeit stellt das aktuelle Therapiekonzept vor und diskutiert den Sinn einer Metastasenresektion.
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Literatur
Alberti W, Bamberg M, Schulz U (1984) Granulosazell-Tumoren. Ergebnisse der postoperativen Bestrahlung. Dtsch Med Wochenschr 109:750–754
Bamberg M, Callies R, Donhuijsen K, Alberti W (1984) Klinik und Therapie der Granulosazell-Tumoren. Dtsch Med Wochenschr 109:755–760
Bartl W, Spernol R, Breitenecker G (1984) Zur Bedeutung klinischer und morphologischer Parameter für die Prognose von Granulosazelltumoren des Ovars. Geburtshilfe Frauenheilkd 44:295–299
Benda JA, Zaleski S (1988) Fine needle aspiration cytologic features of hepatic metastasis of granulosa cell tumor of the ovary. Acta Cytol 32:533–539
Colombo N, Sessa C, Landoni F, Sartori R, Pecorelli S, Mangioni C (1986) Cisplatin, vinblastine and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary. Obstet Gynecol 67:265–268
Evans AT, Thomas AG, Malkasian GD Jr, Annegers JF (1980) Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 55:231–238
Fox H, Agrawal K, Langley FA (1975) A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer 35:231–241
Jacobs AJ, Deppe G, Cohen CJ (1982) Combination chemotherapy of ovarian granulosa cell tumor with cis-Platinum and doxorubicin. Gynecol Oncol 14:294–297
Lappöhn RE, Burger HG, Bouma J, Bangah M, Krans M, Bruijn HWA de (1989) Inhibin as a marker for granulosa-cell tumors. N Engl J Med 321:790–793
Li MKW, Walt JD van der (1984) Recurrent granulosa cell tumor of the ovary 22 years after primary excision. J R Coll Surg Edinb 29:192–194
Nakashima N, Young RH, Scully RE (1984) Androgenic granulosa cell tumors of the ovary. Arch Pathol Lab Med 108:786–791
Pal SK, Chowdhury NNR (1986) Late recurrence of granulosa cell tumor. Asia Oceania J Obstet Gynaecol 12:21–23
Pankratz E, Boyes DA, White GW, Galliford BW, Fairey RN, Benedet JL (1978) Granulosa cell tumors. A clinical review of 61 cases. Obstet Gynecol 52:718–723
Scharl A, Vierbuchen M, Kusche M, Bolte A (1988) Zur Klinik und Prognose von Granulosazelltumoren des Ovars. Geburtshilfe Frauenheilkd 48:567–573
Stenwig JT, Hazekamp JT, Beecham JB (1979) Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long-term follow-up. Gynecol Oncol 7:136–152
Vassal G, Flamant F, Cillaud JM, Demeocq F, Nihoul-Fekete C, Lemerle J (1988) Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. J Clin Oncol 6:990–995
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Belz, J., Wakker, R., Hoepffner, J. et al. Metastasenchirurgie beim Granulosazelltumor — Erörterungen zur Indikationsstellung und Tumornachsorge. Langenbecks Arch Chir 377, 25–27 (1992). https://doi.org/10.1007/BF00186145
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DOI: https://doi.org/10.1007/BF00186145