Summary
The development of pericardial villi and their relation to the development of the cardiac surface was studied in chick embryos from the 3rd to 10th day of incubation by scanning electron microscopy. During the 3rd day of incubation (stage 14–17 HH) the coelomic epithelium covering the ventral wall of the sinus venosus forms villous protrusions. By the end of the 3rd day (stage 17 HH) these protrusions contact the dorsal wall of the heart, so that a secondary dorsal mesocardium is formed. This bridges the pericardial cavity between the ventral wall of the sinus venosus and the dorsal base of the ventricles. This sinu-ventricular mesocardium exists only temporarily, as on the 8th day of incubation it becomes a part of the cardiac wall due to fusion with the epicardium of the coronary sulcus. During the 4th and 5th day of incubation (stage 17 – 25 HH), the formation of the epicardium proceeds from the point of attachment of the sinu-ventricular mesocardium. Although these findings suggest that the epithelium of the villous protrusions spreads over the surface of the embryonic heart, one cannot exclude other hypotheses on epicardial origin. The impression of a spreading epicardium could also be created if epicardial cells were to delaminate from a local epithelium in a temporally and spatially organized pattern.
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References
Asami I (1979) Development of the outflow tract of the rat embryonic heart. 5th European Anatomical Congress, Prag, Argumenta Communicationum: 14
Born G (1889) Beitrage zur Entwicklungsgeschichte des Säugetierherzens. Arch Mikrosk Anat 33:284–378
Davis CL (1924) The cardiac jelly of the chick embryo. Anat Rec 27:201–202
De Haan RL (1965) Morphogenesis of the vertebrate heart. In: De Haan RL, Ursprung H (eds) Organogenesis. Holt, Reinhardt and Winston, New York, pp 377–419
Grant RT (1926) Development of the cardiac coronary vessels in the rabbits. Heart 13:261–271
Greil A (1903) Beiträge zur vergleichenden Anatomie und Entwicklungsgeschichte des Herzens und des Truncus arteriosus der Wirbelthiere. Gegenbaurs Morphol JB 31:123–310
Hamburger V, Hamilton HL (1951) A series of normal stages in the development of the chick embryo. J Morphol 88:49–92
Hamilton HL (1952) Lillie's Development of the chick. 3rd edn. Holt, New York
Hiruma T, Hirakow R (1989) Epicardial formation in embryonic chick heart: computer-aided reconstruction, scanning and transmission electron microscopic studies. Am J Anat 184:129–138
His W (1881) Mittheilungen zur Embryologie der Säugethiere und des Menschen. Arch Anat Entwickl Gesch Jg 1881:303–329
His W (1885) Anatomie menschlicher Embryonen. Teil III Zur Geschichte der Organe. Vogel, Leipzig
Hochstetter F (1906) Beiträge zur Anatomie und Entwicklungsgeschichte des Blutgefäßsystems der Krokodile. In: Voeltzkow A (ed) Reise in Ostafrika. Wissenschaftliche Ergebnisse. Anatomie und Entwicklungsgeschichte. Vol 4, pp 1–133
Kölliker A (1879) Entwicklungsgeschichte des Menschen und der Thiere, 2. Aufl. Engelmann, Leipzig
Komiyama M, Ito K, Shimada Y (1987) Origin and development of the epicardium in the mouse embryo. Anat Embryol 176:183–189
Kuhn HJ, Liebherr G (1988) The early development of the epicardium in Tupaja belangerie. Anat Embryol 177:225–234
Kurkiewicz T (1909) O histogenezie miesnia sercowego zwierzat kregowych — Zur Histogenese des Herzmuskels der Wirbeltiere. Bull Internat Acad Sci Cracovie: 148–191
Langford JK, Hay DA, Bolender DL (1990) Fine structural features of coronary vasculogenesis in collagen lattices. In: Bockman DA, Kirby ML (eds) Embryonic origins of defective heart development. Ann NY Acad Sci 588:404–408
Lieberkühn N (1876) Über die Allantois und die Nieren von Säuge-thierembryonen. Sitzungsberichte d Ges z Beförderung der gesamten Naturwiss z Marburg 1:1–11
Los JA, Verwoerd CDA (1972) The development of a primary venous system from epicardial villi in the cardiac wall of the chicken and the mouse embryo, and the relationship between this venous system and the arterial vascularisation in the mouse. Acta Morphol Neerl Scand 8:233
Manasek FJ (1968) Embryonic development of the heart I. A light and electron microscopic study of myocardial development in the early chick embryo. J Morphol 125:329–366
Manasek FJ (1969) Embryonic development of the heart II. Formation of the epicardium. J Embryol Exp Morphol 22:333–348
Patten BM (1922) The formation of the cardiac loop in the chick. Am J Anat 30:373–397
Remak R (1843) Über die Entwicklung des Hühnchens im Ei. Arch Anat Physiol Wiss Med Jg 1843:478–484
Remak R (1855) Untersuchungen über die Entwicklung der Wirbel-thiere. Berlin
Shimada Y, Ho E (1980) Scanning electron microscopy of the embryonic chick heart: formation of the epicardium and surface structure of the four heterotypic cells that contribute to the embryonic heart. In: van Praagh R, Takao A (eds) Etiology and morphogenesis of congenital heart disease. Futura, New York, pp 63–80
Shimada Y, Ho E, Toyota N (1981) Epicardial covering over myocardial wall in the chicken embryo as seen with the scanning electron microscope. Scanning Electron Microsc 11:275–280
Steinhoff W (1971) Zur Entwicklung der terminalen Strombahn im Hühnerherzen. Anat Entwickl Gesch 134:255–277
Uskow N (1883a) Über die Entwicklung des Zwerchfells, des Pericardiums und des Coeloms. Arch Mikrosk Anat 22:143–219
Uskow N (1883b) Bemerkungen zur Entwicklungsgeschichte der Leber und der Lungen. Arch Mikrosk Anat 22:219–227
Viragh S, Challice CE (1973) Origin and differentiation of cardiac muscle cells in the mouse. J Ultrastruct Res 42:1–24
Viragh S, Challice CE (1981) The origin of the epicardium and the embryonic myocardial circulation in the mouse. Anat Rec 201:157–168
Viragh S, Kalman F, Gittenberger de Groot AC, Poelmann RE, Moorman AFM (1990) Angiogenesis and hematopoesis in the epicardium of the vertebrate embryo heart. In: Bockman DE, Kirby ML (eds) Embryonic origins of defective heart development. Ann NY Acad Sci 588:455–458
Voboril Z, Schiebler TH (1969) Über die Entwicklung der Gefaßversorgung des Rattenherzens. Anat Entwickl Gesch 129:24–40
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Männer, J. The development of pericardial villi in the chick embryo. Anat Embryol 186, 379–385 (1992). https://doi.org/10.1007/BF00185988
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DOI: https://doi.org/10.1007/BF00185988