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Growth factors as mediators of androgen action during the development of the male urogenital tract

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Summary

Studies on the developing prostate and SV suggest that androgens act via mesenchymal AR to elicit synthesis and secretion of various autocrine and paracrine factors that regulate epithelial and stromal growth and differentiation. Clearly, the global regulation of epithelial growth and ductal branching morphogenesis is a complex multifactorial process involving the interplay of many diffusible factors (both positive and negative regulators), extracellular matrix molecules, cell-surface receptors for growth factors, receptors for extracellular matrix molecules, and matrix-degrading enzymes. Future progress will certainly be dependent upon the utilization of appropriate, biologically relevant models to examine the respective roles of various growth factors in the growth and development of androgen target organs.

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References

  1. Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1991) Keratinocyte growth factor: a fibroblast growth factor family member with unusual target cell specificity. Ann NY Acad Sci 638:62–77

    Google Scholar 

  2. Alarid ET, Cunha GR, Young P, Nicoll CS (1991) Evidence for a possible organ- and sex-specific role of bFGF in the development of the fetal mammalian reproductive tract. Endocrinology 129:2148–2154

    Google Scholar 

  3. Alarid ET, Rubin JS, Young P, Chedid M, Ron D, Aaronson SA, Cunha GR (1994) Keratinocyte growth factor functions in epithelial induction during seminal vesicle development. Proc Natl Acad Sci USA 91:1074–1078

    Google Scholar 

  4. Amalric F, Baldin V, Bosc-Bierne I, Bugler B, Couderc B, Guyader M, Patry V, Prats H, Roman AM, Bouche G (1991) Nuclear translocation of basic fibroblast growth factor. Ann NY Acad Sci 638:127–138

    Google Scholar 

  5. Atfi A, Samperez S, Jouan P (1994) Secretion of transforming growth factor-beta by the immature rat prostate. Prostate 24:149–155

    Google Scholar 

  6. Banerjee PP, Banerjee S, Sprando RL, Zirkin BR (1991) Regional cellular heterogeneity and DNA synthetic activity in rat ventral prostate during postnatal development. Biol Reprod 45:773–782

    Google Scholar 

  7. Barnes D, Sato G (1980) Methods for growth of cultured cells in serum-free medium. Anal Biochem 102:255–270

    Google Scholar 

  8. Barni T, Vannelli BG, Sadri R, Pupilli C, Ghiandi P, Rizzo M, Selli C, Serio M, Fiorelli G (1994) Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-4 in human prostatic hyperplastic tissue: gene expression and its cellular localization. J Clin Endocrinol Metab 78:778–783

    Google Scholar 

  9. Berns EM, Schuurmans AL, Bolt J, Lamb DJ, Foekens JA, Mulder E (1990) Antiproliferative effects of suramin on androgen responsive tumor cells. Eur J Cancer 26:470–474

    Google Scholar 

  10. Birnbaum RS, Ware JL, Plymate SR (1994) Insulin-like growth factor-binding protein-3 expression and secretion by cultures of human prostate epithelial cells and stromal fibroblasts. J Endocrinol 141:535–540

    Google Scholar 

  11. Bottaro DP, Rubin JS, Ron D, Finch PW, Florio C, Aaronson SA (1990) Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem 265:12767–12770

    Google Scholar 

  12. Buchanan LJ, Riches AC (1986) Proliferative responses of rat ventral prostate: effects of variations in organ culture media and methodology. Prostate 8:63–74

    Google Scholar 

  13. Carmena MJ, Fernandez-Moreno MD, Prieto JC (1986) Characterization of insulin receptors in isolated epithelial cells of rat ventral prostate: effect of fasting. Cell Biochem Function 4:19–24

    Google Scholar 

  14. Ching KZ, Ramsey E, Pettigrew N, D'Cunha R, Jason M, Dodd JG (1993) Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell lines. Mol Cell Biochem 126:151–158

    Google Scholar 

  15. Coffey DS, Berry SJ, Ewing LL (1987) An overview of current concepts in the study of benign prostatic hyperplasia. In: Rodgers CH, Coffey DS, Cunha GR, Grayhack JT, Hinman JF, Horton R (eds) Benign prostatic hyperplasia. U.S. Government Printing Office, Washington, D.C., pp 1–14

    Google Scholar 

  16. Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR (1987) Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 328:817–820

    Google Scholar 

  17. Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG (1992) Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab 75:1046–1053

    Google Scholar 

  18. Connolly JM, Rose DP (1989) Secretion of epidermal growth factor and related polypeptides by the DU 145 human prostate cancer cell line. Prostate 15:177–186

    Google Scholar 

  19. Connolly JM, Rose DP (1994) Regulation of DU145 human prostate cancer cell proliferation by insulin-like growth factors and its interaction with the epidermal growth factor autocrine loop. Prostate 24:167–175

    Google Scholar 

  20. Cunha GR, Young P (1991) Inability of Tfm (testicular feminization) epithelial cells to express androgen-dependent seminal vesicle secretory proteins in chimeric tissue recombinants. Endocrinology 128:3293–3298

    Google Scholar 

  21. Cunha GR, Young P, Higgins SJ, Cooke PS (1991) Neonatal seminal vesicle mesenchyme induces a new morphological and functional phenotype in the epithelia of adult ureter and ductus deferens. Development 111:145–158

    Google Scholar 

  22. Cunha GR, Alarid ET, Turner T, Donjacour AA, Boutin EL, Foster BA (1992) Normal and abnormal development of the male urogenital tract: role of androgens, mesenchymal-epithelial interactions and growth factors. J Androl 13:465–475

    Google Scholar 

  23. Davies P, Eaton CL (1989) Binding of epidermal growth factor by human normal, hypertropic, and carcinomatous prostate. Prostate 14:123–132

    Google Scholar 

  24. De Pablo F, Scott LA, Roth J (1990) Insulin and insulin-like growth factor I in early development: peptides, receptors and biological events. Endocrine Rev 11:558–577

    Google Scholar 

  25. Derynck R (1986) Transforming growth factor-α: structure and biological activities. J Cell Biochem 32:293–304

    Google Scholar 

  26. Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV (1985) Human transforming growth factor-b complementary DNA sequencing and expression in normal and transformed cells. Nature 316:701–705

    Google Scholar 

  27. Derynck R, Linquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ, Moses HL, Chen EY (1988) A new type of transforming growth factor-β, TGFβ3. EMBO J 7:3737–3743

    Google Scholar 

  28. Djakiew D (1992) Role of nerve growth factor-like protein in the paracrine regulation of prostate growth. J Androl 13:476–487

    Google Scholar 

  29. Djakiew D, Pflug B, Onoda M (1993) Stromal-epithelial paracrine interactions in the neoplastic rat and human prostate. Adv Exp Med Biol 330:185–202

    Google Scholar 

  30. Eaton CL, Davies P, Phillips ME (1988) Growth factor involvement and oncogene expression in prostatic tumours. J Steroid Biochem 30:341–345

    Google Scholar 

  31. Elson SD, Browne CA, Thorburn GD (1984) Identification of epidermal growth factor-like activity in human male reproductive tissues and fluids. J Clin Endocrinol Metab 58:589–597

    Google Scholar 

  32. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (1989) Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245:752–755

    Google Scholar 

  33. Finch PW, Cunha GR, Rubin JS, Wong J, Ron D (1995) Pattern of KGF and KGFR expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions. Dev Dynam 203:223–240

    Google Scholar 

  34. Fiorelli G, DeBellis A, Longo A, Natali A, Constantini A, Serio M (1989) Epidermal growth factor receptors in human hyperplastic prostate tissue and their modulation by chronic treatment with a gonadotropin-releasing hormone analog. J Clin Endocrinol Metab 68:740–743

    Google Scholar 

  35. Fowler JE, Lau JLT, Ghosh L, Mills SE, Mounzer A (1988) Epidermal growth factor and prostatic carcinoma: an immunohistochemical study. J Urol 139:857–861

    Google Scholar 

  36. Furuya Y, Isaacs JT (1993) Differential gene regulation during programmed death (apoptosis) versus proliferation of prostatic glandular cells induced by androgen manipulation. Endocrinology 133:2660–2666

    Google Scholar 

  37. Geller J, Sionit LR, Baird A, Kohls M, Connors KM, Hoffmann RM (1994) In vivo and in vitro effects of androgen on fibroblast growth factor-2 concentrations in the human prostate. Prostate 25:206–209

    Google Scholar 

  38. Gleason PE, Jones JA, Regan JS, Salvas DB, Eble JN, Lamph WW, Vlahos CJ, Huang WL, Falcone JF, Hirsch KS (1993) Platelet derived growth factor (PDGF), androgens and inflammation: possible etiologic factors in the development of prostatic hyperplasia. J Urol 149:1586–1592

    Google Scholar 

  39. Graham CW, Lynch JH, Djakiew D (1992) Distribution of nerve growth factor-like protein and nerve growth factor receptor in human benign prostatic hyperplasia and prostatic adenocarcinoma. J Urol 147:1444–1447

    Google Scholar 

  40. Gregory H, Willshire IR, Kavanagh JP, Blacklock NJ, Chowdury S, Richards RC (1986) Urogastrone-epidermal growth factor concentrations in prostatic fluid of normal individuals and patients with benign prostatic hypertrophy. Clin Sci 70:359–363

    Google Scholar 

  41. Harper ME, Goddard L, Glynne-Jones E, Wilson DW, Price-Thomas M, Peeling WB, Griffiths K (1993) An immunocytochemical analysis of TGF alpha expression in benign and malignant prostatic tumors. Prostate 23:9–23

    Google Scholar 

  42. Hayward SW, Dahiya R, Cunha GR, Bartek J, Despande N, Narayan P (1995) Establishment and characterization of an immortalized but non-tumorigenic human prostate epithelial cell Line: BPH-1. In Vitro (in press)

  43. Hill DJ, Milner RDG (1985) Insulin as a growth factor. Pediatr Res 19:879–886

    Google Scholar 

  44. Hiramatsu M, Kashimata M, Minami N, Sato A, Murayama M, Minami N (1988) Androgenic regulation of epidermal growth factor in the mouse ventral prostate. Biochem Int 17:311–317

    Google Scholar 

  45. Hirata Y, Uchihashi M, Hazama M, Fujita T (1987) Epidermal growth factor in human seminal plasma. Horm Metab Res 19:35–37

    Google Scholar 

  46. Hofer DR, Sherwood ER, Bromberg WD, Mendelsohn J, Lee C, Kozlowski JM (1991) Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor alpha. Cancer Res 51:2780–2785

    CAS  PubMed  Google Scholar 

  47. Iwamura M, Sluss PM, Casamento JB, Cockett AT (1993) Insulin-like growth factor I: action and receptor characterization in human prostate cancer cell lines. Prostate 22:243–252

    Google Scholar 

  48. Jacobs SC, Story MT (1988) Exocrine secretion of epidermal growth factor by the rat prostate: effect of adrenergic agents, cholinergic agents and vasoactive intestinal peptide. Prostate 13:79–87

    Google Scholar 

  49. Katz AE, Benson MC, Wise GJ, Olsson CA, Bandyk MG, Sawczuk IS, Tomashefsky P, Buttyan R (1989) Gene activity during the early phase of androgen-stimulated rat prostate regrowth. Cancer Res 49:5889–5894

    Google Scholar 

  50. Kim JH, Sherwood ER, Sutkowski DM, Lee C, Kozlowski JM (1991) Inhibition of prostatic tumor cell proliferation by suramin: alterations in TGF alpha-mediated autocrine growth regulation and cell cycle distribution. J Urol 146:171–176

    Google Scholar 

  51. Kishi H, Ishibe T, Usui T, Miyachi Y (1988) Epidermal growth factor (EGF) in seminal plasma and prostatic gland: a radioreceptor assay. Arch Androl 20:243–249

    Google Scholar 

  52. Kyprianou N, Isaacs JT (1988) Identification of a cellular receptor for transforming growth factor-beta in rat ventral prostate and its negative regulation by androgens. Endocrinology 123:2124–2131

    Google Scholar 

  53. Kyprianou N, Isaacs JT (1989) Expression of transforming growth factor-β in the rat ventral prostate during castration-induced programmed cell death. Mol Endocrinol 3:1515–1522

    Google Scholar 

  54. Kyprianou N, Martikainen P, Davis L, English HF, Isaacs JT (1991) Programmed cell death as a new target for prostatic cancer therapy. In: Isaacs JT (ed) Prostate cancer: cell and molecular mechanisms in diagnosis and treatment. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 265–278

    Google Scholar 

  55. Lee DC, Rochford RM, Todaro GJ, Villareal LP (1985) Developmental expression of rat transforming growth factor-α mRNA. Mol Cell Biol 5:3644–3646

    Google Scholar 

  56. Liu LM, Nicoll CS (1988) Evidence for a role of basic fibroblast growth factor in rat embryonic growth and differentiation. Endocrinology 123:2027–2031

    Google Scholar 

  57. Lubrano C, Petrangeli E, Catizone A, Santonati A, Concolino G, Rombola N, Frati L, Di Silverio F, Sciarra F (1989) Epidermal growth factor binding and steroid receptor content in human benign prostatic hyperplasia. J Steroid Biochem 34:499–504

    Google Scholar 

  58. MacDonald A, Chisholm GD, Habib FK (1990) Production and response of a human prostatic cancer line to transforming growth factor-like molecules. Br J Cancer 62:579–584

    Google Scholar 

  59. MacGrogan D, Saint AJ, Dicou E (1992) Expression of nerve growth factor and nerve growth factor receptor genes in human tissues and in prostatic adenocarcinoma cell lines. J Neurochem 59:1381–1391

    Google Scholar 

  60. Maddy SQ, Chisholm GD, Hawkins RA, Habib FK (1987) Localization of epidermal growth factor receptors in the human prostate by biochemical and immunocytochemical methods. J Endocrinol 113:147–153

    Google Scholar 

  61. Madisen L, Webb NR, Rose TM, Marquardt H, Ikeda T, Twardzik D, Seyedin S, Purchio AF (1988) Transforming growth factor-β2, cDNA cloning and sequence analysis. DNA 7:1–8

    Google Scholar 

  62. Mansson PE, Adams P, Kan M, McKeehan WL (1989) Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors. Cancer Res 49:2485–2494

    Google Scholar 

  63. Marchese C, Rubin J, Ron D, Faggioni A, Torrisi MR, Messina A, Frati L, Aaronson SA (1990) Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J Cell Physiol 144:326–332

    Google Scholar 

  64. Marquardt H, Hunkapiller MW, Hood LE, Todaro G (1984) Rat transforming growth factor type 1: structure and relation to epidermal growth factor. Science 223:1079–1082

    Google Scholar 

  65. Martikainen P, Kyprianou N, Isaacs JT (1990) Effect of transforming growth factor-beta 1 on proliferation and death of rat prostatic cells. Endocrinology 127:2963–2968

    Google Scholar 

  66. Mason IJ, Pace FF, Smith R, Dickson C (1994) FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalization and epithelial-mesenchymal interactions. Mech Dev 15:15–30

    Google Scholar 

  67. Massagué J (1990) Transforming growth factor-α: a model for membrane-anchored growth factors. J Biol Chem 265:21 393–21 396

    Google Scholar 

  68. McKeehan WL (1991) Growth factor receptors and prostate cell growth. In: Isaacs JT (ed) Prostate cancer: cell and molecular mechanisms in diagnosis and treatment. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 165–176

    Google Scholar 

  69. McKeehan WL, Adams PS (1988) Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta. In Vitro Cell Dev Biol 24:243–246

    Google Scholar 

  70. McKeehan WL, Crabb JW (1987) Isolation and characterization of different molecular and chromatographic forms of heparin-binding growth factor 1 from bovine brain. Anal Biochem 164:563–569

    Google Scholar 

  71. McKeehan WL, Adams PS, Rosser MP (1984) Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture. Cancer Res 44:1998–2010

    Google Scholar 

  72. McKeehan WL, Adams PS, Fast D (1987) Different hormonal requirements for androgen-independent growth of normal and tumor epithelial cells from rat prostate. In Vitro Cell Dev Biol 23:147–152

    Google Scholar 

  73. McKeehan WL, Kan M, Hou J, Wang F, Adams P, Mansson PE (1991) Heparin-binding (fibroblast) growth factor/receptor gene expression in the prostate. In: Karr J, Coffey DS, Smith RG, Tindall DJ (eds) Molecular and cell biology of prostate cancer. Plenum, New York, pp 115–126

    Google Scholar 

  74. Miki T, Fleming TP, Bottaro DP, Rubin JS, Ron D, Aaronson SA (1991) Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 251:72–75

    Google Scholar 

  75. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM-L, Aaronson SA (1992) Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 89:246–251

    Google Scholar 

  76. Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R (1989) Murine transforming growth factor B2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol 3:1108–1114

    Google Scholar 

  77. Mori HM, Maki K, Oishi M, Jaye K, Igarashi O, Hatanaka M (1990) Increased expression of genes for basic fibroblast growth factor and transforming growth factor type β2 in human benign prostatic hyperplasia. Prostate 16:71–80

    Google Scholar 

  78. Mulder E, Loon D van, Boer W de, Schuurmans AL, Bolt J, Voorhorst MM, Kuiper GG, Brinkmann AO (1989) Mechanisms of androgen action: recent observations on the domain structure of androgen receptors and the induction of EGF receptors by androgens in prostate tumor cells. J Steroid Biochem 32:151–156

    Google Scholar 

  79. Muller JW, Lee FS, Dickson C, Peters G, Pattengale P, Leder P (1990) The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J 9:907–913

    Google Scholar 

  80. Myers RB, Kudlow JE, Grizzle WE (1993) Expression of transforming growth factor-alpha, epidermal growth factor and the epidermal growth factor receptor in adenocarcinoma of the prostate and benign prostatic hyperplasia. Mod Pathol 6:733–737

    Google Scholar 

  81. Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D, Lonai P (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol 158:475–486

    Google Scholar 

  82. Pai LH, Gallo MG, FitzGerald DJ, Pastan I (1991) Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40). Cancer Res 51:2808–2812

    Google Scholar 

  83. Peehl DM, Stamey TA (1986) Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone. Prostate 8:51–61

    Google Scholar 

  84. Pesonen K, Viinikka L, Koskimies A, Banks AA, Nicholson M, Perheentupa J (1987) Size heterogeneity of epidermal growth factor in human body fluids. Life Sci 40:2489–2494

    Google Scholar 

  85. Pflug BR, Onoda M, Lynch JH, Djakiew D (1992) Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines. Cancer Res 52:5403–5406

    Google Scholar 

  86. Pienta KJ, Isaacs WB, Vindivich D, Coffey DS (1991) The effects of basic fibroblast growth factor and suramin on cell motility and growth of rat prostate cancer cells. J Urol 145:199–202

    Google Scholar 

  87. Polychronakos C, Janthly U, Lehoux JG, Koutsilieris M (1991) Mitogenic effects of insulin and insulin-like growth factors on PA-III rat prostate adenocarcinoma cells: characterization of the receptors involved. Prostate 19:313–321

    Google Scholar 

  88. Prins GS, Cooke PS, Birch L, Donjacour AA, Yalcinkaya TM, Siiteri PK, Cunha GR (1992) Androgen receptor expression and 5α-reductase activity along the proximal-distal axis of the rat prostatic duct. Endocrinology 130:3066–3073

    Google Scholar 

  89. Rappolee DA, Brenner CA, Schultz R, Mark D, Werb Z (1988) Developmental expression of PDGF, TGF-alpha, and TGF-β genes in preimplantation mouse embryos. Science 241:1823–1825

    Google Scholar 

  90. Rechler MM, Podskalny JM, Nissley SP (1976) Interaction of multiplication-stimulating activity with chick embryo fibroblasts demonstrates a growth receptor. Nature 259:134

    Google Scholar 

  91. Rechler MM, Podskalny JM, Nissley SP (1977) Characterization of the binding of multiplication-stimulating activity to a receptor for growth polypeptides in chick embryo fibroblasts. J Biol Chem 252:3898–3910

    Google Scholar 

  92. Reiter E, Bonnet P, Sente B, Dombrowicz D, de Leval J, Closset J, Hennen G (1992) Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats. Mol Cell Endocrinol 88:77–87

    Google Scholar 

  93. Rubin JS, Bradshaw RA (1984) Preparation of guinea pig prostate epidermal growth factor. In: Barnes DW, Sirbasku DA, Sato GH (eds) Methods for preparation of media, supplements, and substrata for serum-free animal cell culture. Cell culture methods for molecular and cell biology. Alan R. Liss, New York, pp 139–145

    Google Scholar 

  94. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (1989) Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 86:802–806

    Google Scholar 

  95. Rubin JS, Peehl DM, Chedid M, Alarid ET, Cunha GR, Ron D, Aaronson SA (1992) KGF is a paracrine mediator of epithelial cell growth and development in the male reproductive tract. Proceedings, 2nd international symposium on the biology of prostatic growth. NIH Publ 14

  96. Samsoonder J, Kobrin MS, Kudlow JE (1986) α-Transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. J Biol Chem 261:14408–14413

    Google Scholar 

  97. Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC (1990) Overexpression of TGFα in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 61:1121–1135

    Google Scholar 

  98. Schuurmans ALG, Bolt J, Voorhorst MM, Bankenstein RA, Mulder E (1988) Regulation of growth and epidermal growth factor receptor levels of LnCaP prostate tumor cells by different steroids. Int J Cancer 42:917–922

    Google Scholar 

  99. Sehgal I, Bailey J, Hitzemann K, Pittelkow MR, Maihle NJ (1994) Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells. Mol Biol Cell 5:339–347

    Google Scholar 

  100. Shaikh N, Lai L, McLoughlin J, Clark D, Williams G (1990) Quantitative analysis of epidermal growth factor in human benign prostatic hyperplasia and prostatic carcinoma and its prognostic significance. Anticancer Res 10:873–874

    Google Scholar 

  101. Shain SA, Lin AL, Koger JD, Karaganis AG (1990) Rat prostate cancer cells contain functional receptors for transforming growth factor-beta. Endocrinology 126:818–825

    Google Scholar 

  102. Sherwood ER, Fong C-J, Lee C, Kozlowski JM (1992) Basic fibroblast growth factor: a potential mediator of stromal growth in the human prostate. Endocrinology 130:2955–2963

    Google Scholar 

  103. Shikata H, Utsumi N, Hiramatsu M, Minami N, Nemoto N, Shikata T (1983) Immunohistochemical localization of nerve growth factor and epidermal growth factor in guinea pig prostate gland. Histochemistry 80:411–413

    Google Scholar 

  104. Sitaras NM, Sariban E, Bravo M, Pantiazis P, Antoniades HN (1988) Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines. Cancer Res 48:1930–1935

    Google Scholar 

  105. Skinner MK, Takacs K, Coffey RJ (1989) Transforming growth factor-α gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions. Endocrinology 124:845–854

    Google Scholar 

  106. St Amaud R, Poyet P, Walder P, Labrie F (1988) Androgens modulate epidermal growth factor receptor levels in the rat ventral prostate. Mol Cell Endocrinol 56:21–27

    Google Scholar 

  107. Story MT (1991) Polypeptide modulators of prostatic growth and development. In: Isaacs JT (ed) Prostate cancer: cell and molecular mechanisms in diagnosis and treatment. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 123–146

    Google Scholar 

  108. Story MT, Livingston B, Baeten L, Swartz SJ, Jacobs SC, Begun FP, Lawson RK (1989) Cultured human prostate-derived fibroblasts produce a factor that stimulates their growth with properties indistinguishable from basic fibroblast growth factor. Prostate 15:355–365

    Google Scholar 

  109. Straus DS (1984) Growth stimulatory actions of insulin in vitro and in vivo. Endocrine Rev 5:356–369

    Google Scholar 

  110. Sugimura Y, Cunha GR, Donjacour AA, Bigsby RM, Brody JR (1986) Whole-mount autoradiography study of DNA synthetic activity during postnatal development and androgen-induced regeneration in the mouse prostate. Biol Reprod 34:985–995

    Google Scholar 

  111. Sugimura Y, Cunha GR, Hayward S, Haysahi N, Arima K, Kawamura J, Rubin J, Aaronson S (1993) Keratinocyte growth factor (KGF) is a mediator of testosterone-induced prostatic development. Mol Cell Differ 1:423

    Google Scholar 

  112. Tanji N, Tsuji M, Terada N, Takeuchi M, Cunha GR (1994) Inhibitory effects of TGF-β1 on androgen-induced development of neonatal mouse seminal vesicles in vitro. Endocrinology 134:1155–1162

    Google Scholar 

  113. Taylor TB, Ramsdell JS (1993) Transforming growth factor-alpha and its receptor are expressed in the epithelium of the rat prostate gland. Endocrinology 133:1306–1311

    Google Scholar 

  114. Timme TL, Truong LD, Merz VW, Krebs T, Kadmon D, Flanders KC, Park SH, Thompson TC (1994) Mesenchmal-epithelial interactions and transforming growth factor-b expression during mouse prostate morphogenesis. Endocrinology 134:1039–1045

    Google Scholar 

  115. Traish AM, Wotiz HH (1987) Prostatic epidermal growth factor receptors and their regulation by androgens. Endocrinology 121:1461–1467

    CAS  PubMed  Google Scholar 

  116. Tsuji M, Shima H, Cunha GR (1991) Morphogenetic and proliferative effects of testosterone and insulin on the neonatal mouse seminal vesicle in vitro. Endocrinology 129:2289–2297

    Google Scholar 

  117. Vlahos CJ, Kriauciunas TD, Gleason PE, Jones JA, Eble JN, Salvas D, Falcone JF, Hirsch KS (1993) Platelet-derived growth factor induces proliferation of hyperplastic human prostatic stromal cells. J Cell Biochem 52:404–413

    Google Scholar 

  118. Wilding G, Valvarius E, Knabbe C, Gelmann EP (1989) The role of transforming growth factor alpha in human prostate cancer cell growth. Prostate 15:1–12

    Google Scholar 

  119. Wilding G, Zugmeier G, Knabbe C, Flanders K, Gelmann E (1989) Differential effects of transforming growth factor-β on human prostate cancer cells in vitro. Mol Cell Endocrinol 62:79–87

    Google Scholar 

  120. Wu HH, Kawamata H, Kawai K, Lee C, Oyasu R (1993) Immunohistochemical localization of epidermal growth factor and transforming growth factor alpha in the male rat accessory sex organs. J Urol 150:990–993

    Google Scholar 

  121. Xu J, Nakahara M, Crabb JW, Shi E, Matuo Y, Fraser M, Kan M, Hou J, McKeehan WL (1992) Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms. J Biol Chem 267:17792–18803

    Google Scholar 

  122. Yan GC, Nikolaropoulos S, Wang F, McKeehan WL (1991) Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7). In Vitro Cell Dev Biol 27A:437–438

    Google Scholar 

  123. Yan G, Fukabori Y, Nikolaropoulos S, Wang F, McKeehan WL (1992) Heparin-binding keratinocyte growth factor is a candidate stromal to epithelial cell andromedin. Mol Endocrinol 6:2123–2128

    Google Scholar 

  124. Yan G, Fukabori Y, McBride G, Nikolaropoulos S, McKeehan WL (1993) Exon switching and activation of stromal and embryonic FGF/FGF receptor genes in prostate epithelial cells accompanies stromal independence and malignancy. Mol Cell Biol 13:4513–4522

    Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, University of California, 94143, San Francisco, CA, USA

    G. R. Cunha, B. Foster, A. Thomson & A. A. Donjacour

  2. Department of Urology, Mie University Medical School, Mie-Ken, 2-174, Edobashi, Japan

    Y. Sugimura

  3. Department of Urology, Ehime University Medical School, Onsengun, 791-02, Ehime, Japan

    N. Tanji

  4. Division of Pathology, Itami City Hospital, Itami, 664, Hyogo, Japan

    M. Tsuji

  5. Department of Pathology, The Center for Adult Diseases, Higashinari-ku, 537, Osaka, Japan

    N. Terada

  6. Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center, One Gustave L. Levy Place, 10029-6574, New York, NY, USA

    P. W. Finch

Authors
  1. G. R. Cunha
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  2. B. Foster
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  3. A. Thomson
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  4. Y. Sugimura
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  5. N. Tanji
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  6. M. Tsuji
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  7. N. Terada
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  8. P. W. Finch
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  9. A. A. Donjacour
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Additional information

Supported by NIH grants DK 32157, CA 59831, DK47517, DK 45861, and CA64872.

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Cunha, G.R., Foster, B., Thomson, A. et al. Growth factors as mediators of androgen action during the development of the male urogenital tract. World J Urol 13, 264–276 (1995). https://doi.org/10.1007/BF00185969

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  • DOI: https://doi.org/10.1007/BF00185969

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