European Journal of Plastic Surgery

, Volume 19, Issue 3, pp 162–165 | Cite as

Evaluation of cynthaskin and topical steroid in the treatment of hypertrophic scars and keloids

  • N. W. Yii
  • J. D. Frame
Ideas and innovations


The combined use of cynthaskin, as an occlusive and hydrating agent, and triamcinolone acetonide, incorporated as a topical steroid, was investigated in a prospective study in the treatment of hypertrophic scars and keloids. The product is a lotion which dries up to form an adherent and transparent film, a property that offers unique advantage in the treatment of scars and keloids on the face and other exposed parts of the body. Forty-one patients were studied: 32 with hypertrophic scars (group A) and 9 patients with keloids (group B). In group A, 84.4% of the patients improved after treatment, compared to 44.4% in group B. The difference in response to treatment between the two groups is significant (p=0.03). However, all patients in both groups achieved symptomatic relief of itch and pain.

Key words

Cynthaskin Triamcinolone Scars Keloids 


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  1. 1.
    Ahn ST, Monafo WM, Mustoe TA (1991) Topical silicone gel for the prevention and treatment of hypertrophic scar. Arch Surg 126:499–504Google Scholar
  2. 2.
    Goldman L, Thompson RG, Trice ER (1952) Cortisone acetate in skin disease. Arch Dermatol Syph 65:177–186Google Scholar
  3. 3.
    Goldblatt S, de Stefano GA, MacMillan BG (1971) Influence of topical steroids on hypertrophic scars and keloids following traumatic wounds and surgical incisions. In: Matter P, Barclay TL, Konickova (eds) Research in burns. Huber, Bern Stuttgart Vienna, pp 413–417Google Scholar
  4. 4.
    Griffith BH (1966) Treatment of keloids with triamcinolone acetonide. Plast Reconstr Surg 38:202–208Google Scholar
  5. 5.
    Groel JT (1968) Dimethylsulfoxide as a vehicle for corticosteroids. Arch Dermatol 97:110–114Google Scholar
  6. 6.
    Hirshowitz B, Ullman Y, Har-Shai Y, Vilenski A, Peted IJ (1993) Silicone occlusive sheeting (SOS) in the management of hypertrophic and keloid scarring, including the possible mode of action of silicone, by static electricity. Eur J Plast Surg 16:5–9Google Scholar
  7. 7.
    Janssen de Limpens AMP (1986) A comparison of the treatment of keloids and hypertrophic scars. Eur J Plast Surg 9:18Google Scholar
  8. 8.
    Ketchum LD, Smith J, Robinson DW, Masters FW (1966) Treatment of hypertrophic scar, keloid and scar contracture by triamcinolone acetonide. Plast Reconstr Surg 38:209–218Google Scholar
  9. 9.
    Lawrence WT (1991) In search of the optimal treatment of keloids: report of a series and review of the literature. Ann Plast Surg 27:164–178Google Scholar
  10. 10.
    Marsden CW (1968) Flucinolone acetonide 0.2% cream - a cooperative clinical trial. Br J Dermatol 80:614–617Google Scholar
  11. 11.
    Masterton JP (1991) Statement regarding cynthaskin TM. In: Cynthaskin for burns and infection control. Cynthaskin Pty Ltd, AustraliaGoogle Scholar
  12. 12.
    Mercer NSG (1989) Silicone gel in the treatment of keloid cars. Br J Plast Surg 42:83–87Google Scholar
  13. 13.
    Ohmori S (1988) Effectiveness of silastic sheet coverage in the treatment of scar keloid (hypertrophic scar). Aesth Plast Surg 12:95–99Google Scholar
  14. 14.
    Perkins K, Davey RB, Wallis KA (1982) Silicone gel: a new treatment for burns, scars and contractures. Burns 9:210–204Google Scholar
  15. 15.
    Quinn KJ, Evans JH, Courtney JM, Gaylor JDS (1985) Nonpressure treatment of hypertrophic scars. Burns 12:102–108Google Scholar
  16. 16.
    Quinn KJ (1987) Silicone gel in scar treatment, Burns 13 [Suppl]:833–840Google Scholar
  17. 17.
    Ratzer MA (1970) A clinical trial of flurandrenolone tape. Br J Clin Pract 24:185–189Google Scholar
  18. 18.
    Sawada Y, Sone K (1990) Treatment of scars and keloids with a cream containing silicone oil. Br J Plast Surg 43:683–688Google Scholar
  19. 19.
    Sawada Y, Sone K (1992) Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg 45:599–603Google Scholar
  20. 20.
    Sproat JE, Dalcin A, Weitauer N, Roberts RS (1992) Hypertrophic sternal scars: silicone gel sheet versus kenalog injection treatment. Plast Reconstr Surg 90:988–992Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • N. W. Yii
    • 1
  • J. D. Frame
    • 1
  1. 1.North East Thames Regional Plastic Surgery and Burns UnitSt. Andrew's HospitalBillericay, EssexUK

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