Abstract
Bioplastique, a biphasic polymer of textured dimetylpolysiloxane is reported to be useful in filling small soft tissue defects. The microparticles range in size from 100 to 600 p and are suspended in a hydrogel carier from the family of the plasdones. The bioexcretable gel component is rapidly phagocytized and replaced by fibrin-like matrix with in a few days. In this study it is aimed to observe the local and systemic effects of Bioplastique and gel silicone in comparison. Our study in rabbit ears has shown that Bioplastique caused severe foreign body reaction in injection site and showed no migration to lymph nodes. On the other hand, silicone gel caused fibrous encapsulation and showed migration to lymph nodes, and formation of granulomatous reaction.
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References
Allison AC, Harington JS, Birbeck M (1966) An examination of the cytotoxic effects of silica on macrophages. J Exp Med 124:141
Beisang AA, Ersek RA (1992) Mammalian response to subdermal implantation of textured microimplants. Aesth Plast Surg 16:83–90
Boros DL (1978) Granulomatous inflammation. Prog Allergy 24:183–267
Boskovic DM (1993) Use of tissue expanders in reconstruction after excision of multiple large silicone granulomas (Letter). Ann Plast Surg 31:379
Brantley SK et al (1990) Assessment of the lymphocyte response to silicone. Plast Reconstr Surg 86:1131–1137
Christie AJ, Weinberger KA, Dietrich M (1977) Silicone lymphadenopathy and synovitis. JAMA 237:1463–1464
Ersek RA, Beisang AA (1992) Bioplastique: a new biphasic polymer for minimally invasive injection implantation. Aesth Plast Surg 16:59–65
Ersek RA, Beisang AA (1991) Bioplastique: a new textured copolymer microparticle promises permanence in soft tissue augmentation. Plast Reconstr Surg 87:693–702
Habal MB (1984) The biologic basis for the clinical application of the silicones. Arch Surg 119:843–848
Heggers JP, Kossovsky N, Parsons RW et al (1983) Biocompatibility of silicone implants. Ann Plast Surg 11:38
Jackson IT, de Fontain S, Tanner BNS (1994) Removal of bioplastique after nasal augmentation. Eur J Plast Surg 17:154–156
Kubota J, Fujino T, Sugimoto C, Abe T (1984) Long term complications caused by injected silicone gel and paraffin oil. Keio J Med 33:127–136
Mitnick JS et al (1993) Fine needle aspiration biopsy in patients with augmentation prostheses and a palpable mass. Ann Plast Surg 31:241–244
Mladick RA (1992) Twelve months of experience with bioplastique. Aesth Plast Surg 16:69–76
Rees TD, Ballatyne DL, Seidman I, Hawthorne GA (1967) Visceral response to subcutaneous and intraperitoneal injections of silicone in mice. Plast Reconstr Surg 39:402
Sergott TJ, Limoli JP, Baldwin CM, Laub DR (1986) Human adjuvant disease, possible autoimmune disease after silicone implantation: a review of the literature, case studies, and speculation for the future. Plast Reconstr Surg 78:104–114
Simons G, Mazaleyrat P, Masurel T (1992) Utilization of injectable microimplants in aesthetic facial surgery. Aesth Plast Surg 16:77–82
Spira M, Rosen T (1993) Injectable soft tissue substitutes. Clin Plast Surg 20:181–188
Travis WD, Balogh MD, Abraham JL (1985) Silicone granolomas: report of three cases and review of the literature. Hum Pathol 16:19–27
Wickham MG, Rudolph R, Abraham JL (1978) Silicone identification in prosthesis-associated fibrous capsules. Science 199:437
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Deveci, M., Selmanpakoglu, N. & Kömürcü, E. A comparative experimental study of silicone gel and bioplastique. Eur J Plast Surg 19, 139–143 (1996). https://doi.org/10.1007/BF00185760
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DOI: https://doi.org/10.1007/BF00185760