Abstract
An intrathyroid primary epithelial spindle-cell tumor with mucous cysts is described in a 9-year-old child. Histologically, this well-circumscribed tumor exhibited a nodular pattern, a prominent spindle cell component with minimal pleomorphism, and well-differentiated mucinous glands within fibrous bands. The spindle cells demonstrated diffuse immunopositivity for cytokeratin and vimentin. Electron microscopy of tissue sections demonstrated that cells contained bundles of cytoplasmic tonofilaments and numerous desmosomes. The light and electron microscopic features and immunohistochemical profile of this tumor were similar to those of recently described thyroid tumors that have been called “SETTLE” tumors (i.e., spindle epithelial tumor with thymus-like differentiation). These uncommon tumors can be considered intrathyroid thymoblastomas and must be regarded as potentially malignant lesions.
References
Asa SL, Dardick I, Van Nostrand PV, Bailey DJ, Gullane PJ (1988) Primary thyroid thymoma: a distinct clinicopathologic entity? Hum Pathol 191463–1467
Buckwalter JA, Gurll NJ, Thomas GG (1981) Cancer of the thyroid in youth. World J Surg 5: 15–25
Chan JKC, Rosai J (1991) Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Hum Pathol 22:349–367
Damiani S, Filotico M, Eusebi V (1991) Carcinoma of the thyroid showing thymoma-like features. Virchows Arch [A] 418:463–466
Enzinger FM, Weiss SW (1988) Soft tissue tumors, 2nd edn. Mosby, St. Louis, pp 665–682
Ganter P, Jolles G (1970) Histochimie normale et pathologique. Masson, Paris, pp 1426–1427
Gilmur JR (1941) Some developmental abnormalities of the thymus and parathyroids. J Pathol Bacteriol 52:213–218
Hajdu SI, Hajdu EO (1967) Malignant teratoma of the neck. Arch Pathol Lab Med 83:567–570
Harach HR, Day ES, Franssila KO (1985) Thyroid spindle cell tumor with mucous cysts: an intrathyroid thymoma? Am J Surg Pathol 19:525–530
Hsu SM, Raine L, Fanger H (1981) The use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Kakudo K, Mori I, Tamaoki N, Watanabe K (1988) Carcinoma of possible thymic origin presenting as a thyroid mass: a new subgroup of squamous cell carcinoma of the thyroid. J Surg Oncol 38:187–192
Kingsley DPE, Elton A, Benett MH (1968) Malignant teratoma of the thyroid: case report and review of the literature. Br J Cancer 22:7–11
Levey M (1976) An unusual thyroid tumor in child. Laryngoscope 86:1684–1688
Miyauchi A, Kuma K, Matsuzuka F, Matsubayashi S, Kobayashi A, Tamai H, Katayoma S (1985) Intrathyroidal epithelial thymoma: an entity distinct from squamous cell carcinoma of the thyroid. World J Surg 9:128–135
Murao T, Nakanishi M, Toda K (1979) Malignant teratoma of the thyroid gland in an adolescent female. Acta Pathol Jpn 29: 109–117
Neil1 J (1986) Intrathyroid thymoma. Am J Surg Pathol 10: 660–661
Pages A, Girardot B (1993) Chorista thymiques cervicaux. Ann Pathol 13:164–169
Rosai J (1989) Ackerman's surgical pathology, 7th edn. Mosby, St. Louis, pp 345–447
Roth J, Enzinger FM, Tannenbaum M (1975) Synovial sarcoma of the neck: a follow-up study of 24 cases. Cancer 35 1243–1253
Shareef DS, Salm R (1981) Ectopic vestigial lesions of the neck and shoulders. J Clin Pathol 34:1155–1162
Skier KJ (1981) The thymus according to Schambacher: medullary ducts and reticular epithelium of thymus and thymomas. Cancer 48:1183–1199
Stone H, Henderson WD, Guidio FA (1967) Teratomas of the neck. Am J Dis Child 113: 222–224
Suster S, Rosai J (1990) Histology of the normal thymus. Am J Surg Pathol 14:284–303
Weigensberg C, Dalsley H, Asa SL, Bedard YC, Mullen JBM (1990) Thyroid thymoma in childhood. Endocr Pathol 1: 123–127
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Hofman, P., Mainguené, C., Michiels, J.F. et al. Thyroid spindle epithelial tumor with thymus-like differentiation (the “settle” tumor). Eur Arch Otorhinolaryngol 252, 316–320 (1995). https://doi.org/10.1007/BF00185397
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DOI: https://doi.org/10.1007/BF00185397