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Alpha-adrenoceptor blockers in the treatment of benign prostatic hyperplasia

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Summary

Alpha-adrenoceptors have been demonstrated within tissues in benign prostatic hyperplasia. In vitro experiments have shown a reduction in smooth muscle tone within prostate strips after addition of alpha-adrenoceptor blocking agents. A small but significant increase in maximal flow rate and improvement in symptoms have been reported in placebo-controlled trials of alpha-adrenoceptor blocking agents. The long-term efficacy of such agents is not yet known.

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References

  1. Abrams PH, Shah PJR, Stone R, Choa RG (1982) Bladder outflow obstruction treated with phenoxybenzamine. Br J Urol 54:527–530

    Google Scholar 

  2. Ball AJ, Feneley RCL, Abrams P (1981) The natural history of untreated prostatism. Br J Surg 53:613–616

    Google Scholar 

  3. Bartsch G, Frick J, Rüegg I, Bucher M, Holliger O, Oberholzer M, Rohr HP (1979) Electron microscopic stereological analysis of the human prostate and of benign prostatic hyperplasia. J Urol 122:481–486

    Google Scholar 

  4. Boreham PF, Braithwaite P, Milewski P, Pearson H (1977) Alphaadrenergic blockers in prostatism. Br J Surg 64:756–757

    Google Scholar 

  5. Boyarsky S, Jones G, Paulson DF, Prout GR (1977) A new look at bladder neck obstruction by the Food and Drug Administration regulators: guidelines for investigation of benign prostatic hypertrophy. Trans Am Assoc Genitourin Surg 68:29–32

    Google Scholar 

  6. Brooks ME, Sidi AA, Hanani Y, Braf ZF (1983) Ineffectiveness of phenoxybenzamine in treatment of benign prostatic hypertrophy. A controlled study. Urology 21:474–478

    Google Scholar 

  7. Caine M (1986) The present role of alpha-adrenergic blockers in the treatment of benign prostatic hypertrophy. J Urol 136:1–4

    Google Scholar 

  8. Caine M (1988) Alpha-adrenergic mechanisms in dynamics of benign prostatic hypertrophy. Urology [Suppl] 32:16–20

    Google Scholar 

  9. Caine M, Raz S, Zeigler M (1975) Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Br J Urol 47:193–202

    Google Scholar 

  10. Caine M, Pfau A, Perlberg S (1976) The use of alpha-adrenergic blockers in benign prostatic obstruction. Br J Urol 48:255–259

    Google Scholar 

  11. Caine M, Perlberg S, Meretyk S (1978) A placebo controlled trial of the effect of phenoxybenzamine in benign prostatic obstruction. Br J Urol 50:551–554

    Google Scholar 

  12. Caine M, Perlberg S, Shapiro A (1981) Phenoxybenzamine for benign prostatic obstruction. Urology 17:542–546

    Google Scholar 

  13. Caine M, Mazouz B, Rossini BM (1984) The effect of nicergoline on the lower urinary tract muscle. Urol Res 12:287–290

    Google Scholar 

  14. Chapple CR, Aubry ML, James S, Greengrass PM, Burnstock G, Turner-Warwick RT, Milroy EJG, Davey MJ (1989) Characterisation of human prostatic adrenoceptors using pharmacology receptor binding and localisation. Br J Urol 63:487–496

    Google Scholar 

  15. Chapple CR, Christmas TJ, Milroy EJG (1990) A twelve week placebo-controlled study of prazosin in the treatment of prostatic obstruction. Urol Int 45:47–55

    Google Scholar 

  16. Chow W, Hahn D, Sandhu D, Slaney P, Henshaw R, Das G, Wells P (1990) Multicentre controlled trial of indoramin in the symptomatic relief of benign prostatic hypertrophy. Br J Urol 65:36–38

    Google Scholar 

  17. Creed KE, Tulloch AGS (1978) The effect of pelvic nerve stimulation and some drugs on the urethra and bladder of the dog. Br J Urol 50:598–602

    Google Scholar 

  18. Dunzendorfer U (1988) Clinical experience: symptomatic management of BPH with terazosin. Urology [Suppl] 32:27–31

    Google Scholar 

  19. Dunzendorfer U, Jonas D, Weber W (1976) The autonomic innervation of the human prostate. Histochemistry of acetylcholinesterase in the normal and pathological state. Urol Res 4:29–31

    Google Scholar 

  20. Furuya S, Kumamoto Y, Yokoyama E, Tsukamoto T, Izumi T, Abiko Y (1982) Alpha-adrenergic activity and urethral pressure in prostatic zone in benign prostatic hypertrophy. J Urol 128:836–839

    Google Scholar 

  21. Gerstenberg T, Blaaberg J, Nielsen ML, Clausen S (1980) Phenoxybenzamine reduces bladder outlet obstruction in benign prostatic hyperplasia. A urodynamic investigation. Invest Urol 18:29–31

    Google Scholar 

  22. Giberti C, Damonte P, Michelotti P, Martorana G (1984) The effect of thymoxamine in benign prostatic hypertrophy: a double-blind cross-over study. IRCS Med Sci 12:591

    Google Scholar 

  23. Hedlund H, Andersson KE (1988) Effects of prazosin and carbachol in patients with benign prostatic hypertrophy. Scand J Urol Nephrol 22:19–22

    Google Scholar 

  24. Hedlund H, Andersson KE, Ek A (1983) Effect of prazosin in patients with benign prostatic obstruction. J Urol 130:275–278

    Google Scholar 

  25. Hedlund H, Andersson KE, Larsson B (1985) Alpha receptors and muscarinic receptors in the isolated human prostate. J Urol 134:1291–1298

    Google Scholar 

  26. Hieble JP, Caine M, Zalaznik E (1985) In vitro characterisation of the alpha-adrenoceptors in human prostate. Eur J Pharmacol 107:111–117

    Google Scholar 

  27. Horby-Petersen J, Schmidt PF, Meyhoff HH, Frimodt-Moller C, Mathiesen FR (1985) The effects of a new serotonin receptor antagonist (ketanserin) on the lower urinary tract function in patients with prostatism. J Urol 133:1095–1098

    Google Scholar 

  28. Iacovou JW, Dunn M (1987) Indoramin — an effective new drug in the management of bladder outflow obstruction. Br J Urol 60:526–528

    Google Scholar 

  29. James S, Chapple CR, Phillips MI, Greengrass PM, Davey MJ, Turner-Warwick RT, Milroy EJG, Burnstock G (1989) Autoradiographic analysis of alpha-adrenoceptors and muscarinic cholinergic receptors in the hyperplastic human prostate. J Urol 142:438–444

    Google Scholar 

  30. Jensen D (1981) Uninhibited neurogenic bladder treated with prazosin. Scand J Urol Nephrol 15:229–233

    Google Scholar 

  31. Kirby RS, Coppinger SWC, Corcoran MO, Chapple CR, Flannigan M, Milroy EJG (1987) Prazosin in the treatment of prostatic obstruction. A placebo controlled study. Br J Urol 60:136–142

    Google Scholar 

  32. Kleeman FJ (1970) The physiology of the internal urinary sphincter. J Urol 104:549–552

    Google Scholar 

  33. Krane RJ, Olsson CA (1973) Phenoxybenzamine in neurogenic bladder dysfunction: I. A theory of micturition. J Urol 110:650–652

    Google Scholar 

  34. Kunisawa Y, Kawabe K, Niijima T, Honda K, Takenaka T (1985) A pharmacological study of alpha adrenoceptor sub-types in smooth muscle of human urinary bladder base and prostatic urethra. J Urol 134:396–398

    Google Scholar 

  35. Lepor H, Shapiro E (1984) Characterization of alpha-1 adrenergic receptors in human benign prostatic hyperplasia. J Urol 132:1226–1229

    Google Scholar 

  36. Lepor H, Gup DI, Bauman M, Shapiro E (1988) Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia. Urology [Suppl] 32:21–26

    Google Scholar 

  37. Lepor H, Knapp-Maloney G, Sunshine H (1990) The efficacy and safety of terazosin for the treatment of BPH (abstract). J Urol 143:267

    Google Scholar 

  38. Leventhal A, Pfau A (1978) Pharmacologic management of postoperative overdistension of the bladder. Surg Gynecol Obstet 146:347–349

    Google Scholar 

  39. Levin RM, Wein AJ (1979) Distribution and function of adrenergic receptors in the urinary bladder of the rabbit. Mol Pharmacol 16:441–448

    Google Scholar 

  40. Malone PR, Cook A, Edmondson R, Gill MW, Shearer RJ (1988) Prostatectomy: patients' perception and long-term follow-up. Br J Urol 61:234–238

    Google Scholar 

  41. Martorana G, Giberti C, Damonte P, Ciprandi G, Dirienzo W, Giuliani L (1984) The effect of prazosin in benign prostatic hypertrophy, a placebo controlled double-blind study. IRCS Med Sci 12:11–12

    Google Scholar 

  42. Perlberg S, Caine M (1977) Dynamics of acute retention in prostatic patients and role of adrenergic receptors. Urology 9:399

    Google Scholar 

  43. Perlberg S, Caine M (1982) Adrenergic response of bladder muscle in prostatic obstruction. Urology 11:524–528

    Google Scholar 

  44. Ramsay JWA, Scott GI, Whitfield HN (1985) A double blind controlled trial of a new alpha-1 blocking drug in the treatment of bladder outflow obstruction. Br J Urol 57:657–659

    Google Scholar 

  45. Raz S, Zeigler M, Caine M (1973) Pharmacological receptors in the prostate. Br J Urol 45:663–668

    Google Scholar 

  46. Reuther K, Aagaard J (1984) Acute retention of urine due to benign prostatic obstruction treated with alpha-adrenergic blockers. Urol Int 39:114–118

    Google Scholar 

  47. Ronchi F, Margonato A, Ceccardi R, Rigatti P, Rossini BM (1982) Symptomatic treatment of benign prostatic obstruction with nicergoline: a placebo-controlled clinical study and urodynamic evaluation. Urol Res 10:131–134

    Google Scholar 

  48. Roos NP, Wennberg JE, Malenka DJ, Fisher ES, McPherson K, Andersen TF, Cohen MM, Ramsey E (1989) Mortality and reoperation rate after open and transurethral resection of the prostate from benign prostatic hyperplasia. New Engl J Med 320:1120–1124

    Google Scholar 

  49. Rossi MA, Carillo SV (1985) Does norepinephrine play a central causative role in the process of cardiac hypertrophy? Am Heart J 100:622–624

    Google Scholar 

  50. Shapiro E, Lepor H (1986) Alpha-2 adrenergic receptors in hyperplastic human prostate: identification and characterisation using [3H]-Rauwolscine. J Urol 135:1038–1042

    Google Scholar 

  51. Shapiro E, Mazouz B, Caine M (1981) The alpha adrenergic effect of prazosin on the human prostate. Urol Res: 9:17–20

    Google Scholar 

  52. Siroky MB, Olsson CA, Krane RJ (1979) The flow rate nomogram: I. Development. J Urol 122:665–668

    Google Scholar 

  53. Vaalasti A, Hervonen A (1980) Autonomic innervation of the human prostate. Invest Urol 17:293–297

    Google Scholar 

  54. Whitfield HN, Doyle PT, Mayo ME, Poopalasingham N (1976) The effect of adrenergic blocking drugs on outflow resistance. Br J Urol 47:823–827

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology, St. Bartholomew's Hospital, West Smithfield, EC1A 7BE, London, UK

    T. J. Christmas & R. S. Kirby

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  1. T. J. Christmas
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  2. R. S. Kirby
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Christmas, T.J., Kirby, R.S. Alpha-adrenoceptor blockers in the treatment of benign prostatic hyperplasia. World J Urol 9, 36–40 (1991). https://doi.org/10.1007/BF00184712

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