Summary
Brain natriuretic peptide (BNP) is synthesized and released predominantly in the ventricular myocardium whereas atrial natriuretic peptide (ANP) is produced mainly in the atria. This study evaluated whether artificial pacemaker stimulation or left heart catheterization results in specific changes in BNP and ANP plasma levels. Both BNP and ANP responded sensitively to changes in pacemaker stimulation (single-chamber pacemakers; pacing rates of 72 and 92/min) and during the left heart catheterization procedure. However, whereas higher pacing resulted in a more pronounced increase in plasma BNP levels, a stronger ANP release followed catheterization. This incongruous rise in ANP and BNP plasma concentrations points to at least partly independent mechanisms govering the release of BNP and ANP.
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Abbreviations
- ANP:
-
atrial natriuretic peptide
- BNP:
-
brain natriuretic peptide
References
Cantin M, Genest J (1985) The heart and the atrial natriuretic factor. Endocr Rev 6:107–127
Christensen G, Leistad E, Ilebekk A (1991) Active tension development, not passive atrial stretch stimulates release of atrial natriuretic factor during pacing tachycardia. Circulation 84 [Suppl II]: 628
Edwards BS, Zimmermann RS, Schwab TR, Heublein DM, Burnett JC (1988) Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor. Circ Res 62:191–195
Forssmann WG, Hock D, Mutt V (1986) Cardiac hormones: morphology and biochemistry. Klin Wochenschr 64 [Suppl VI]: 4–12
Gardner DG, Deschepper CF, Ganong WF, Hane S, Fiddes J, Baxter JD, Lewicki J (1986) Extra-atrial expression of the gene for atrial natriuretic factor. Proc Natl Acad Sci USA 83:6697–6701
Hasegawa K, Fujiwara H, Fujiwara T, Kawai C (1991) Light and electron microscopic localization of atrial and brain natriuretic peptides in ventricular myocardium with dilated cardiomyopathy. Circulation 84 [Suppl II]:629
Hasegawa K, Fujiwara H, Itoh H, Nakao K, Fujiwara T, Imura H, Kawai C (1991) Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium. Circulation 84:1203–1209
Hashiguchi T, Higuchi K, Ohashi M, Minamino N, Kangawa K, Matsuo H, Nawata H (1988) Porcine brain natriuretic peptide, another modulator of bovine adrenocortical steroidogenesis. FEBS Lett 236:55–61
Hosoda K, Nakao K, Mukoyama M, Saito Y, Jougasaki M, Shirakami G, Suga S, Ogawa Y, Yasue H, Imura H (1991) Expression of brain natriuretic peptide gene in human heart. Hypertension 17:1152–1156
Kambayashi Y, Nakao K, Mukoyama M, Saito Y, Ogawa Y, Shiono S, Inouye K, Yoshida N, Imura H (1990) Isolation and sequence determination of human brain natriuretic peptide in human atrium. FEBS Lett 259:341–345
Keogh AM, Baron DW, Hickie JB (1990) Prognostic guides in patients with idiopathic or ischemic dilated cardiomyopathy assessed for cardiac transplantation. Am J Cardiol 65:903–908
Lang CC, Choy AM, Khong TK, Motwani JG, Struthers AD (1991) Brain natriuretic peptide: its release and metabolism in man. Circulation 84 [Suppl II]:108
Lang RE, Thölken H, Ganten D, Luft FC, Ruskoaho H, Unger T (1985) Atrial natriuretic factor — a circulating hormone stimulated by volume loading. Nature 314:264–266
Mancini GBJ, McGillem MJ, Bates ER, Weder AB, DeBoe SF, Grekin RJ (1987) Hormonal responses to cardiac tamponade: inhibition of release of atrial natriuretic factor despite elevation of atrial pressures. Circulation 76:884–890
McDonough PM, Glembotski CC (1991) Paced contractions stimulate expression of atrial natriuretic factor in cultured neonatal ventricular heart cells. Circulation 84 [Suppl II]:397
Morii N, Nakao K, Matsumori A, Tomioka Y, Kawai C, Imura H (1989) Increased synthesis and secretion of atrial natriuretic polypeptide during viral myocarditis. J Cardiovasc Pharmacol 13:5–8
Mukoyama M, Nakao K, Saito Y, Ogawa Y, Hosoda K, Suga S, Shirakami G, Jougasaki M, Imura H (1990) Increased brain natriuretic peptide in congestive heart failure. N Engl J Med 323:757
Mukoyama M, Nakao K, Saito Y, Ogawa Y, Hosoda K, Suga S, Shirakami G, Jougasaki M, Imura H (1990) Human brain natriuretic peptide, a novel cardiac hormone. Lancet 335:801–802
Needleman P, Greenwald JE (1986) Atriopeptin: a cardiac hormone imately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med 314:828–834
Noll B, Krappe J, Göke B, Maisch B (1989) Influence of pacing mode and rate on peripheral levels of atrial natriuretic peptide (ANP). PACE 12:1763–1768
Noll B, Krappe J, Göke B, Maisch B (1990) Atrial natriuretis peptide levels reflect hemodynamic changes under pacemaker stimulation. PACE 13:970–975
Noll B, Walthers E, Christ E, Klose KJ, Maisch B (1991) Atriales natriuretisches Peptid (ANP). Plasmaspiegel unter intravasaler Kontrastmittelgabe. Muench Med Wochenschr 133:657–659
Saito Y, Nakao K, Arai H, Sugawara A, Morii N, Yamada T, Itch H, Shiono S, Mukoyama M, Obata K (1987) Atrial natriuretic polypeptide (ANP) in human ventricle: increased gene expression of ANP in dilated cardiomyopathy. Biochem Biophys Res Commun 148:211–217
Sudoh T, Kangawa K, Minamino N, Matsuo H (1988) A new natriuretic peptide in porcine brain. Nature 332:78–81
Yasue H, Morita E, Yoshimura M, Jougasaki M, Mukoyama M, Nakao K, Imura H (1991) Increased plasma levels of brain natriuretic peptide in acute myocardial infarction. Circulation 84 [Suppl II]:291
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Noll, B., Göke, B., Simon, B. et al. Cardiac natriuretic peptide hormones during artificial cardiac pacemaker stimulation and left heart catheterization. Clin Investig 70, 1057–1060 (1992). https://doi.org/10.1007/BF00184543
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DOI: https://doi.org/10.1007/BF00184543