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Genetic aspects of bladder cancer progression

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Summary

Neoplasia is the result of cumulative genetic damage. Cytogenetic analysis identifies abnormalities of chromosome number and structure. Abnormal mode, wide variation in chromosome number, and aneuploidy are associated with loss of differentiation and advanced stage in bladder cancer. Marker chromosomes have been associated with increased risk of recurrence and progression of superficial, low-grade tumors. With the use of banding techniques, aberrations can be assigned to specific chromosomes and significant nonrandom abnormalities have been identified on chromosomes 1, 3, 5, 7, 9, 11, and 17. With the use of molecular biology techniques, allelic deletions, proto-oncogene activation, and mutations can be detected and correlated to the pathophysiologic events that determine the biologic behavior of a particular tumor. Allelic deletions of chromosome 9q are independent of stage and grade and suggest that loss of a tumor suppressor gene on chromosome 9q may be an important primary event in the genesis of bladder cancer. Deletions of chromosomes 11p and 17p, evident only in high-grade tumors, may be important in bladder cancer progression.

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Authors and Affiliations

  1. Urologic Cancer Research Laboratories, Kenneth Norris Jr. Cancer Center, University of Southern California School of Medicine, 90033, Los Angeles, California, USA

    S. P. Lerner, Y. C. Tsai & P. A. Jones

Authors
  1. S. P. Lerner
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  2. Y. C. Tsai
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  3. P. A. Jones
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Additional information

This work was supported in part by an American Foundation for Urologic Disease/Natinal Kidney Foundation Fellowship (S.P.L.) and Outstanding Investigator Grant R35 CA49758 from the National Cancer Institute (P.A.J.)

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Lerner, S.P., Tsai, Y.C. & Jones, P.A. Genetic aspects of bladder cancer progression. World J Urol 9, 69–74 (1991). https://doi.org/10.1007/BF00184036

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