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Visual evoked potentials after photostress in insulin-dependent diabetic patients with or without retinopathy

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Abstract

Visual evoked potentials (VEPs) were assessed under basal conditions and after photostress in normal control subjects, in insulin-dependent diabetic patients with retinopathy (IDDPWR) and in insulin-dependent diabetic patients without retinopathy (IDDP). The VEPs recorded under basal conditions showed a P100 latency significantly higher in IDDP and IDDPWR eyes than in control eyes and in IDDPWR than in IDDP eyes (P<0.01). N75-P100 amplitude was significantly lower in IDDP and IDDPWR eyes than in control eyes (P<0.01). No difference was recorded in the N75-P100 amplitudes between IDDP and IDDPWR eyes. In all eyes, the VEPs recorded after photostress showed an increase in latency and a decrease in amplitude. In both IDDPWR eyes and IDDP eyes VEPs recorded at 20, 40 and 60 s after photostress showed higher mean increments in P100 latency than in C control eyes, and IDDPWR eyes showed higher mean increments in P100 latency than IDDP eyes (IDDP vs control P<0.01, IDDPWR vs control P<0.01, IDDPWR vs IDDP P<0.017). The mean reductions in amplitude observed at 20, 40 and 60 s after photostress in IDDP and IDDPWR eyes were lower than in control eyes (IDDP vs control P=0.01, IDDPWR vs control P<0.01, IDDPWR vs IDDP P<0.01). VEPs were superimposable on the basal VEP (recovery time) at 73.9 s in control eyes, at 88.17 s in IDDP eyes and at 113.3 s in IDDPWR eyes. VEPs after photostress in IDDP patients with normal visual acuity and no fluorangiographic signs of retinopathy may show multiple modifications. This may indicate the presence of an early functional deficiency of the central retinal layers.

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References

  1. Algan M, Ziegler O, Gehin P, Got I, Raspiller A, Weber M, Genton P, Saudax E, Drouin P (1989) Visual evoked potentials in diabetic patients. Diabetes Care 12:227–229

    Google Scholar 

  2. Arden GB, Hamilton AMP, Wilson-Holt J, Ryan S, Yudkin JS, Kurtz A (1986) Pattern electroretinograms become abnormal in the preproliferative stage: possible use as a screening test. Br J Ophthalmol 70:330–335

    Google Scholar 

  3. Armington JC (1974) The electroretinogram. Academic Press, New York

    Google Scholar 

  4. Baillart JP (1954) L'examen functionel de la macula. Rapport à la Societè d'Ophthalmologie de Paris. Bull Soc Ophtalmol Fr [Suppl] 4:I-LXVII

    Google Scholar 

  5. Bianchini E, Franchi A, Manni R, Villani LG, Cordella M, Botta GC (1987) Carotid occlusive disease: an electrophysiological macular investigation. J Cardiovasc Surg 28:524–527

    Google Scholar 

  6. Boschi MC, Frosini R, Menicucci R, Sodi A (1989) The influence of early diabetes on pattern electroretinogram. Doc Ophthalmol 71:369–374

    Google Scholar 

  7. Bresnik GH, Palta M (1987) Temporal aspects of the electroretinogram in diabetic retinopathy. Arch Ophthalmol 105:660–664

    Google Scholar 

  8. Bucci MG, Parisi V, Giannini R, Rossini PM (1991) Recordings of visual evoked potentials after photostress in artificially increased intraocular pressure. Clin Vis Sci 6:431–436

    Google Scholar 

  9. Cirillo D, Gonfiantini E, De Grandis D, Bongiovanni L, Robert JJ, Pinelli L (1984) Visual evoked potentials in diabetic children and adolescents. Diabetes Care 7:273–275

    Google Scholar 

  10. Collier A, Mitchell JD (1985) Visual evoked potentials and contrast sensitivity function in diabetic retinopathy. BMJ 291:248

    Google Scholar 

  11. Comi G, Martinelli V, Galardi G, Medaglini S, Poggi A, Beccaria L, Meschi F, Flores D'Arcais A (1986) Visual evoked potentials in diabetic teenagers: influence of metabolic control and relationship with peripheral neuropathy. Methods Pediatr Systems Ophthal 9:85–87

    Google Scholar 

  12. Comi G, Martinelli V, Galardi G, Medaglini S, Beccaria L, Meschi F, Rosti L, Bressani N, Chiumello G (1987) Evaluation of central nervous conduction by visual evoked potentials in insulin-dependent diabetic children. Metabolic and clinical correlation. Acta Diabetol Lat 24:157–162

    Google Scholar 

  13. Cracco J, Castells S, Mark E (1985) Spinal somatosensory evoked potentials in juvenile diabetes. Ann Neurol 15:55–58

    Google Scholar 

  14. Donald MW, Williams-Erdahl DL, Surridge DHC, Monga TN, Lawson JS, Bird CE, Latemendia FJJ (1984) Functional correlation of reduced central conduction velocity in diabetic subjects. Diabetes 33:627–633

    Google Scholar 

  15. Falsini B, Porciatti V, Scalia G, Caputo S, Minnella A, Di Leo MAS, Ghirlanda G (1989) Steady-state electroretinogram in insulin-dependent diabetics with no or minimal retinopathy. Doc Ophthalmol 73:193–200

    Google Scholar 

  16. Franchi A, Magni R, Lodigiani R, Cordella M (1987) Vep pattern after photostress: an index of macular function. Graefe's Arch Clin Exp Ophthalmol 225:291–194

    Google Scholar 

  17. Franzone M, Brunetti GM, Coggi G, Peronzini S (1985) Test del tempo di recupero maculare dopo abbagliamento: attendibilità dell'esame. Boll Oculistica 64 [Suppl 11/12]:141–151

    Google Scholar 

  18. Ghirlanda G, Di Leo MAS, Caputo S, Falsini B, Porciatti V, Marietti G, Greco AV (1991) Detection of inner retina dysfunction by steady-state focal electroretinogram pattern and flicker in early IDDM. Diabetes 9:1122–1127

    Google Scholar 

  19. Gjotteberg M (1974) The electroretinogram in diabetic retinopathy. A clinical study and critical survey. Acta Ophthalmol 52:521–533

    Google Scholar 

  20. Hollander H, Bisti S, Maffei L, Hebel R (1984) Electroretinographic responses and retrograde changes of retinal morphology after intracranial optic nerve section. Exp Brain Res 55:483–494

    Google Scholar 

  21. Klein BEK, Davis MD, Segal P (1984) Diabetic retinopathy: assessment of severity and progression. Ophthalmology 91:10–17

    Google Scholar 

  22. Lovasik JV (1983) An electrophysiological investigation of the macular photostress test. Invest Ophthalmol Vis Sci 24:437–441

    Google Scholar 

  23. Maffei L, Fiorentini A (1981) Electroretinographic responses to alternating gratings before and after section of the optic nerve. Science 211:953–955

    Google Scholar 

  24. Maffei L, Fiorentini A (1982) Electroretinographic responses to alternating gratings in the cats. Exp Brain Res 48:327–334

    Google Scholar 

  25. Maffei L, Fiorentini A, Bisti S, Hollander H (1985) Pattern ERG in the monkey after section of the optic nerve. Exp Brain Res 59:423–425

    Google Scholar 

  26. Martinelli V, Merenda M, Natali-Sora MG, Meschi F, Beccaria L, Comi G (1987) Correlation between pattern electroretinopathy and visual evoked potentials in diabetes. Electroenceph Clin Neurophysiol 66:S64

    Google Scholar 

  27. Martinelli V, Filippi M, Meschi F, Pozza G, Canal N, Comi GC (1991) Electrophysiological study of optic pathways in insulin dependent diabetes mellitus. Clin Vis Sci 6:437–443

    Google Scholar 

  28. Mosci C, Polizzi A, Grillo N, Capris P, Zingirian M (1986) Ottimizzazione del test del recupero maculare nello studio dei soggetti diabetici. Boll Oculistica 65:347–356

    Google Scholar 

  29. Parisi V, Bucci MG (1992) Visual evoked potentials after photostress in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 33:436–442

    Google Scholar 

  30. Parisi V, Uccioli L, Monticone G, Carboni A, Falleni C, Ignagni T, Del Giudice R, Bucci MG (1994) Registrazioni di potenziali evocati visivi e dei potenziali oscillatori dell'elettroretinogramma fotopico in pazienti diabetici insulino-dipendenti con e senza retinopatia. Riv Med Militare (in press)

  31. Porciatti V, von Berger GP (1983) Pattern electroretinogram and visual evoked potentials in optic nerve disease: early diagnosis and prognosis. Doc Ophthalmol Proc Ser 40:117–126

    Google Scholar 

  32. Pozzessere G, Rizzo PA, Valle E, Mollica MA, Sanarelli L, Morano S, Pietravalle P, Di Mario U, Morocutti C (1989) A longitudinal study of multimodal evoked potentials in diabetes mellitus. Diabetes Res 10:17–20

    Google Scholar 

  33. Puvanendran K, Davethasan G, Wong PK (1983) Visual evoked responses in diabetes. J Neurol Neurosurg Psychiatry 46:543–547

    Google Scholar 

  34. Reske-Nielsen E, Lundbaek K, Rafaelsen OJ (1965) Pathological changes in the central and peripheral nervous system of young long-term diabetics. I. Diabetic encephalopathy. Diabetologica 1:223–241

    Google Scholar 

  35. Rizzo P, Carboni M, Passaro R, Parisi V, Del Giudice R, Rizzo A, Terrana P (1988) Potenziali evocati visivi da checkerboard pattern reversal: dati normativi. Riv Med Aeronautica Spaziale 2:99–105

    Google Scholar 

  36. Severin SL, Tour R, Kershaw H (1967) Macular function and the photostress test. Arch Ophthalmol 77:163–167

    Google Scholar 

  37. Simonsen SE (1975) Prognostic value of ERG (oscillatory potentials) in juvenile diabetics. Acta Ophthalmol [Suppl] 123:223–224

    Google Scholar 

  38. Trick GL, Burde RM, Gordon MO, Kilo C, Santiago JV (1988) Retinocortical conduction time in diabetics with abnormal pattern reversal electroretinogram and visual evoked potentials. Doc Ophthalmol 70:19–28

    Google Scholar 

  39. Van Der Torren K, Van Lith G (1989) Oscillatory potentials in early diabetic retinopathy. Doc Ophthalmol 71:375–379

    Google Scholar 

  40. Zingirian M, Castellazzo R, Trillo T (1968) Test del recupero maculare in soggetti normali. Standardizzazione del metodo. Boll Oculistica 47:883–848

    Google Scholar 

  41. Zingirian M, Polizzi A, Grillo N (1985) The macular recovery test after photostress in normal and diabetic subjects. Acta Diabetol Lat 22:169–172

    Google Scholar 

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Authors and Affiliations

  1. Cattedra die Clinica Oculistica, Cattedra di Endicronologia, Universita' di Roma Tor Vergata -Complesso Integrato Columbus, Via della Pineta Sacchetti 506, I-00168, Rome, Italy

    Vincenzo Parisi, Luigi Uccioli, Giovanna Monticone, Guido Menzinger & Massimo G. Bucci

  2. II Clinica Neurologica, Università di Roma La Sapienza, V. le Dell' Università 30, I-00161, Rome, Italy

    Leoluca Parisi

Authors
  1. Vincenzo Parisi
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  2. Luigi Uccioli
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  3. Giovanna Monticone
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  4. Leoluca Parisi
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  5. Guido Menzinger
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  6. Massimo G. Bucci
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Parisi, V., Uccioli, L., Monticone, G. et al. Visual evoked potentials after photostress in insulin-dependent diabetic patients with or without retinopathy. Graefe's Arch Clin Exp Ophthalmol 232, 193–198 (1994). https://doi.org/10.1007/BF00184004

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  • DOI: https://doi.org/10.1007/BF00184004

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