Summary
The present study was undertaken to determine the target sites of polymyxin B ototoxicity. This drug, at the concentration of 1 mM, was perfused through the scala tympani of the guinea pig cochlea, and cochlear microphonics and endocochlear potentials were monitored. Both cochlear potentials altered but in an independent manner. These findings indicated that not only the organ of Corti but also another tissue is involved in the ototoxicity produced. The best locus for this is the vascular stria.
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References
Honrubia V, Strelioff F, Sitko ST (1976) Physiological basis of chochlear transduction and sensitivity. Ann Otol Rhinol Laryngol 85: 697–710
Konishi T (1979) Effects of local application of ototoxic antibiotics on cochlear potentials in guinea pigs. Acta Otolaryngol (Stockh) 88:41–46
Kuijpers W (1969) Cation transport and cochlear function. Thesis, University of Nijmegen
Prazma J, Thomas WG, Fischer ND, Presler MJ (1972) Ototoxicity of the ethacrynic acid. Arch Otolaryngol 95:448–456
Tachibana M, Komiya S, Yamada C, Sokabe M (1984) Correlation of ototoxic effects of polyamino compounds in vivo with effects on triphosphoinositide metabolism and the lysotriphosphoinositide channel in vitro. Proc Jpn Acad 60B: 318–321
Tachibana M, Morioka H, Machino M, Mizukoshi O (1986) Polymyxin-B-binding sites in the cochlea as demonstrated by polymyxin-B/gold labeling. Histochemistry 86:191–194
Thalmann R, Ise I, Bohne BA, Thalmann I (1977) Actions of “loop” diuretics and mercurials upon the cochlea. Acta Otolaryngol (Stockh)83: 221–232
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Komiya, S., Tachibana, M. Target sites of polymyxin B ototoxicity. Eur Arch Otorhinolaryngol 247, 129–130 (1990). https://doi.org/10.1007/BF00183184
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DOI: https://doi.org/10.1007/BF00183184