Abstract
We describe a simple method of pentavalent technetium-99m dimercaptosuccinic acid [99mTc(V)-DMSA] preparation for the imaging of medullary carcinoma of the thyroid using commercially available kits. 99mTc(V)-DMSA is available at high pH (approximately 7.5) by adding NaHCO3 solution in the presence of a small amout of reducing agent (SnCl2). On the other hand, trivalent 99mTc-DMSA [99m-Tc(III)-DMSA] can be obtained at low pH (below 3) in the presence of an excess amount of reducing agent. In the clinical evaluation of a patient with a medullary carcinoma of the thyroid, only 99mTc(V)-DMSA revealed an area of intense accumulation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Clarke SEM, Lazarus Cr, Wraight P, et al. Pentavalent (99mTc)DMSA, (I-131)MIBG, and (99mTc)MDP: an evaluation of three imaging techniques in patiens with medullary carcinoma of the thyroid. J Nucl Med 1998;29: 33–38.
Ohta H, Yamamoto K, Endo K, et al. A new imaging agent for medullary carcinoma of the thyroid. J Nucl Med 1984;25: 323–325.
Ohta H, Endo K, Fujita T, et al. Clinical evaluation of tumour imaging using 99mTc(V) dimercaptosuccinic acid, a new tumour-seeking agent. Nucl Med Commun 1988;9: 105–116.
Westera G, Gadze A, Horst W. A convenient method for the preparation of 99mTc(V) dimercaptosuccinic acid (99mTc(V)-DMSA). Int J Appl Radiat Isot 36: 311–312.
Vanlic-Razumenic N, Petrovic J. Preparation of technetium-99-DMS renal complex in solution and its chemical and biological characterization. Int J App Radiat Isot 1982;33: 277–284.
Clarke SEM, Lazarus CR, Edwards S, et al. Scintigraphy and treatment of medullary carcinoma of the thyroid with iodine-131 metaiodobenzylguanidine. J Nucl Med 1987;28: 182–185.
Keeling CA, Basso LV. Iodine-131 MIBG uptake in metastatic medullary carcinoma of the thyroid; a patient treated with somatostatin. Clin Nucl Med 1988;13: 260–263.
Jeghers O, Puttemans N, Urbain D, et al. Technetium-99m DMSA uptake by metastatic carcinoma of the prostate. J Nucl Med 1983;27: 1223–1224.
Ohta H, Ishii M, Yoshizumi M, et al. A comparison of the tumor-seeking agent Tc-99m(V) dimercaptosuccinic acid and the renal imaging agent Tc-99m dimercaptosuccinic acid in humans. Clin Nucl Med 1985;10: 167–170.
Blower PJ, Singh J, Clarke SEM. The chemical identity of pentavalent technetium-99m-dimercaptosuccinic acid. J Nucl Med 1991;32: 845–849.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hirano, T., Tomiyoshi, K., Zhang, Y.J. et al. Preparation and clinical evaluation of technetium-99m dimercaptosuccinic acid for tumour scintigraphy. Eur J Nucl Med 21, 82–85 (1994). https://doi.org/10.1007/BF00182308
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00182308