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Single-photon emission tomography imaging of dopamine terminal innervation: a potential clinical tool in Parkinson's disease

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References

  1. Uhl GR. Neurotransmitter transporters (plus): a promising new gene family. Trends Neurosci 1992;15: 265–268.

    Google Scholar 

  2. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 1987;237: 1219–1223.

    CAS  PubMed  Google Scholar 

  3. Aquilonius S-M, Bergstrom K, Eckernas S-A, Hartvig P, Leenders KL, Lundquist H, Antoni G, Gee A, Rimland A, Uhlin J, Langstrom B. In vivo evaluation of striatal dopamine reuptake sites using 11C-nomifensine and positron emission tomography. Acta Neural Scand 1987;76: 283–287.

    Google Scholar 

  4. Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, MacGregor RR, Hitzemann R, Logan J, Bendriem B, Gatley SJ, Christman D. Mapping cocaine binding sites in human and baboon in vivo. Synapse 1989;4: 371–377.

    Google Scholar 

  5. Kilbourn MR, Haka MS, Mulholland GK, Jewett DM, Kuhl DE. Synthesis of radiolabeled inhibitors of presynaptic monoamine uptake systems: [18F]GBR 13119 (DA), [11C]nisoxetine (NE), and [11C]fluoxetine (5-HT). J Lab Compd Radiopharm 1989;26: 412.

    Google Scholar 

  6. Shaya EK, Scheffel U, Dannals RF, Ricaurte GA, Carrol FI, Wagner HN Jr, Kuhar MJ, Wong DF. In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPET) and iodine-123 labeled RTI-55. Synapse 1992;10: 169–172.

    Google Scholar 

  7. Neumeyer JL, Wang S, Milius RA, Baldwin RM, Zea-Ponce Y, Hoffer PB, Sybirska E, Al-Tikriti M, Charney DS, Malison RT, Laruelle MA, Innis RB. [123I]-2-β-Carbomethoxy-3-β-(4iodophenyl)-tropane (β-CIT): high affinity SPECT radiotracer of monoamine reuptake sites in brain. J Med Chem 1991;34: 3144–3146.

    Google Scholar 

  8. Janowsky A, Vocci F, Berger P, Angel I, Zelnick N, Kleinman R, Skolnick P, Paul SM. [3H]GBR-12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease. J Neurochem 1987;49: 617–621.

    Google Scholar 

  9. Niznik HB, Fogel EF, Fassos FF, Seeman P. The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus. J Neurochem 1991;56: 192–198.

    Google Scholar 

  10. Kaufman MJ, Madras BK. Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's diseased striatum. Synapse 1991;49: 43–49.

    Google Scholar 

  11. Zelnik N, Angel I, Paul SM, Kleinman JE. Decreased density of human striatal dopamine uptake sites with age. Eur J Pharmacol 1986;126: 175–176.

    Google Scholar 

  12. De Keyser JD, Ebinger G, Vauquelin G. Age-related changes in the human nigrostriatal dopaminergic system. Ann Neurol 1990;27: 157–161.

    PubMed  Google Scholar 

  13. Reith ME, Sershen H, Allen DL, Lajtha A. A portion of [3H]cocaine binding in brain is associated with serotonergic neurons. Mol Pharmacol 1983;23: 600–606.

    Google Scholar 

  14. Clarke RL, Daum SJ, Gambino AJ, Aceto MD, Pearl J, Levitt M, Cumiskey WR, Bogado EF. Compounds affecting the central nervous system. 4. 3β-Phenyltropane-2-carboxylic esters and analogs. J Med Chem 1973;16: 1260–1267.

    Google Scholar 

  15. Madras BK, Spealman RD, Fahey MA, Neumeyer JL, Saha JK, Milius RA. Cocaine receptors labeled by [3H]-2β-carrbomethoxy-3β-(4-fluorophenyl)tropane. Mol Pharmacol 1989;36: 518–524.

    Google Scholar 

  16. Balster RL, Carroll FI, Graham JH, Mansbach RS, Rahman MA, Philip A, Lewin AIL Showalter VM. Potent substituted 3-β-phenyltropane analogs of cocaine have cocaine-like discriminative stimulus effects. Drug Alcohol Depend 1991;29: 145–151.

    Google Scholar 

  17. Carroll FI, Gao Y, Rahman MA, Abraham P, Parham K, Lewin AH, Boja JW, Kuhar MI. Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters. J Med Chem 1991;34: 2719–2725.

    Google Scholar 

  18. Boja JW, Mitchell WM, Patel A, Kopajtic TA, Carroll FI, Lewin AH, Abraham P, Kuhar MI. High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain. Synapse 1992;12: 27–36.

    Google Scholar 

  19. Laruelle M, Giddings SS, Zea-Ponce Y, Charney DS, Neumeyer JL, Baldwin RM, Innis RB. [125I]β-CIT in vitro binding to dopamine and serotonin transporters under “physiological” conditions. J Neurochem (in press).

  20. Laruelle M, Baldwin RM, Malison RT, Zea-Ponce Y, Zoghbi SS, Al-Tikritis MS, Sybirska EH, Zimmermann R, Wisniewski G, Neumeyer JL, Milius RA, Wang S, Smith EO, Roth RH, Charney DS, Hoffer PB, Innis RB. SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse 1993;13: 295–309.

    Google Scholar 

  21. Backstrom I, Bergstrom M, Marcusson J. High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain Res 1989;486: 261.

    Google Scholar 

  22. Laruelle M, Vanisberg M-A, Maloteaux J-M. Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites. Biol Psychiatry 1988;24: 299.

    Google Scholar 

  23. Innis RB, Seibly JP, Wallace E, Scanley E, Laruelle M, Abi-Dargham A, Zea-Ponce Y, Zoghbi S, Charney DS, Wang S, Gao Y, Neumeyer JL, Baldwin RM, Marek R, Hoffer PB. SPECT imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease. Proc Natl Acad Sci USA (in press).

  24. Kish SJ, Shannak K, Hornykiewicz. Uneven pattern of dopamine loss in the stratum of patients with idiopathic Parkinson's disease. N Engl J Med 1988;318: 876–880.

    Google Scholar 

  25. Kilbourn MR, DaSilva IN, Frey KA, Koeppe RA, Kuhl DE. In vivo imaging of vesicular monoamine transporters in human brain using [11C]tetrabenazine and positron emission tomography. J Neurochem 1993;60: 2315–2318.

    Google Scholar 

  26. Kilbourn MR, Sherman PS, Pisani T. Repeated reserpine administration reduces in vivo [18F]GBR 13119 binding to the dopamine uptake site. Eur J Pharmacol 1992;216: 109–112.

    Google Scholar 

  27. Brooks DJ. Functional imaging in relation to parkinsonian syndromes. J Neurol Sci 1993;115: 1–17.

    Google Scholar 

  28. Garnett ES, Firnau G, Nahmias C, Chirakal R. Striatal dopamine metabolism in living monkeys examined in positron emission tomography. Brain Res 1983;280: 169–171.

    Google Scholar 

  29. Jenner P, Marsden CD. MPTP-induced parkinsonism as an experimental model of Parkinson's disease. In: Jankovic J, Tolosa E, eds. Parkinson's disease and movement disorders. Baltimore: Urban and Schwarzenberg; 1988: 37–48.

    Google Scholar 

  30. Boja JW, McNeill RM, Lewin AH, Abraham P, Carroll FI, Kuhar MJ. Selective dopamine transporter inhibition by cocaine analogs. Neuroreport 1992;3: 984–986.

    Google Scholar 

  31. Scheffel U, Dannals RF, Wong DF, Yokoi F, Carroll FI, Kuhar MJ. Dopamine transporter imaging with novel selective cocaine analogs. Neuro Report 1992;3: 969–972.

    Google Scholar 

  32. Al-Tikriti MS, Scanley BE, Zoghbi SS. Zea-Ponce Y, Baldwin RM, Laruelle M, Hoffer JLN, Innis RB. SPECT imaging and ex vivo evaluation of [123I]isopropyl-β-CIT of monoamine uptake sites in baboon. Soc Neurosci Abstr 1993;19: 936.

    Google Scholar 

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  1. Department of Psychiatry, Yale University School of Medicine and West Haven VA Medical Center, 950 Campbell Ave., 06516, West Haven, CT, USA

    Robert B. Innis

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  1. Robert B. Innis
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Innis, R.B. Single-photon emission tomography imaging of dopamine terminal innervation: a potential clinical tool in Parkinson's disease. Eur J Nucl Med 21, 1–5 (1994). https://doi.org/10.1007/BF00182298

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