Skip to main content
Log in

Invasive germ-cell tumor detected by follow-up examination following orchiopexy for cryptorchidism

  • Case Report
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

The authors report the case of a 26-year-old man who was operated upon for bilateral testicular maldescent when he was 11 years old. In a follow-up examination for men with a history of orchiopexy for cryptorchidism, he palpated a dense nodule emerging from his right testis, and therapy for invasive testicular cancer was started. The histologic diagnosis was a mixed teratoma consisting of yolk-sac tumor, differentiated teratoma, and embryonic carcinoma. We conclude that young men with a history of testicular maldescent should be followed up by a multidisciplinary approach and should be offered testicular biopsy after puberty to allow detection and treatment of testicular intraepithelial neoplasia (so-called testicular carcinoma in situ) to prevent invasive testicular cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Burr IM, Sizonenko PC, Kaplan SL, Grumbach MM (1970) Hormonal changes in puberty. I. Correlation of serum luteinizing hormone and follicle-stimulating hormone with stage of puberty, testicular size and bone age in normal boys. Pediatr Res 4: 25–35

    Google Scholar 

  2. De Leval J, Vandeberg C (1993) Testis tumour: the problem of the undescended testis. J Belge Radiol 76: 100–101

    Google Scholar 

  3. Giwercman A, Bruun E, Frimodt-Moller C, Skakkebaek NE (1989) Prevalence of carcinoma in situ and other histopathological abnormalities in testes of men with a history of cryptorchidism. J Urol 142: 998–1001

    Google Scholar 

  4. Hadziselimovic F, Herzog B (1987) Cryptorchidism. Pediatr Surg Int 2: 132–141

    Google Scholar 

  5. Hadziselimovic F, Herzog B (1990) Hodenerkrankungen im Kindesalter. Hippokrates, Stuttgart, pp 24–72

    Google Scholar 

  6. Halme A, Kellokumpu-Lehtinen P, Lehtonen T, Teppo L (1989) Morphology of testicular germ cell tumours in treated and untreated cryptorchidism. Br J Urol 64: 78–83

    Google Scholar 

  7. Hutson JM, Beasley SW (1992) Descent of the testis. Edward Arnold, London Melbourne Auckland, pp 118–145

    Google Scholar 

  8. Jones BJ, Thornhill JA, O'Donnell B, Kelly DG, Walsh A, Fennelly JJ, Fitzpatrick JM (1991) Influence of prior orchiopexy on stage and prognosis of testicular cancer. Eur Urol 19: 201–203

    Google Scholar 

  9. Jorgenson N, Muller J, Giwercman A, Skakkebaek NE (1990) Clinical and biological significance of carcinoma in situ of the testis. Cancer Surv 9: 287–302

    Google Scholar 

  10. Lenz S, Giwercman A, Skakkebaek NE (1987) Ultrasound in detection of early neoplasia of the testis. Int J Androl 10: 209–220

    Google Scholar 

  11. Muffly KE, McWhorter CA, Bartone F, Gardner PJ (1983) The absence of premalignant changes in the cryptorchid testis before adulthood. J Urol 131: 523–524

    Google Scholar 

  12. Nistal M, Codesal J, Paniagua R (1989) Carcinoma in situ of the testis in infertile men. A histological, immunocytochemical and cytophotometric study of DNA content. J Pathol 159: 205–210

    Google Scholar 

  13. Prader A, Largo RH, Wälli R, Fanconi A (1980) Schweizerische Wachstumskurven von der 28. Schwangerschaftswoche bis zum 18. Lebensjahr. Helv Paediatr Acta [Suppl] 45: 32

    Google Scholar 

  14. Rainbolt T (1992) Years of potential life lost: an evaluation of premature cancer deaths in Texas from 1981 through 1988. Tex Med 88: 74–76

    Google Scholar 

  15. Ring KS, Burbige KA, Benson MC, Karp F, Hensle TW (1990) The flow cytometric analysis of undescended testes in children. J Urol 144: 494–498

    Google Scholar 

  16. Stone JM, Cruickshank DG, Sandeman TF, Matthews JP (1991) Laterality, maldescent, trauma and other clinical factors in the epidomiology of testis cancer in Victoria, Australia. Br J Cancer 66: 132–138

    Google Scholar 

  17. Stone JM, Cruickshank DG, Sandeman TF, Matthews JP (1991) Trebling of the incidence of testicular cancer in Victoria, Australia (1950–1985). Cancer 68: 211–219

    Google Scholar 

  18. Swerdlow AJ, Huttly SR, Smith PG (1989) Testis cancer: postnatal hormonal factors, sexual behaviour and fertility. Int J Cancer 43: 549–553

    Google Scholar 

  19. Thornhill JA, Walsh A (1991) A national programme for testis cancer, the Irish Testis Tumor Registry (ITTR). Arch Ital Urol Nefrol Androl 63: 37–42

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mayr, J., Breinl, E., Ratschek, M. et al. Invasive germ-cell tumor detected by follow-up examination following orchiopexy for cryptorchidism. Pediatr Surg Int 10, 427–429 (1995). https://doi.org/10.1007/BF00182250

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00182250

Key words

Navigation