Abstract
The authors report a case of successful reversal of persistent fetal circulation (PFC) by inhaled nitric oxide (NO) therapy in a child with overwhelming sepsis. Criteria for extracorporeal membrane oxygenation (ECMO) were reached but due to an intracranial hemorrhage ECMO was contraindicated. Inhaled NO in combination with surfactant administration caused a dramatic reversal of the PFC. Inhaled NO therapy may be a useful and easily accessible measure for the treatment of PFC. It is more simple, and therefore may be more widely applicable, than ECMO.
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Yamazato, M., Muraji, T., Higashimoto, Y. et al. Successful reversal of persistent fetal circulation by inhaled nitric oxide in a newborn with overwhelming sepsis. Pediatr Surg Int 10, 381–383 (1995). https://doi.org/10.1007/BF00182231
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DOI: https://doi.org/10.1007/BF00182231