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Surgery for Wilms' tumour

The effect of neoadjuvant chemotherapy

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Abstract

A total of 101 patients presenting for nephrectomy for Wilms′ tumour were non-randomly offered primary surgery or pre-operative treatment and were subsequently assessed to determine the effect of the primary treatment on surgical morbidity and mortality. Ease of surgery as indicated by tumour mass and extent of resection was improved in the patients receiving neoadjuvant treatment. Intra-operative complications were also reduced in this group. Significant pre-existing disease compounded both surgical and anaesthetic risk in 20% of patients. No effect of pre-operative treatment on histological grading was evident. Overall operative mortality was 1%.

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References

  1. Alvarez-Silvan A, Carrasco FG, Cuevas GP et al (1989) Preservation of anaplastic features in Wilms′ tumour after preoperative chemotherapy. Med Pediatr Oncol 17: 131–133

    Google Scholar 

  2. Cohen MD (1993) Staging of Wilms′ tumour. Clin Radiol 47: 77–81

    Google Scholar 

  3. Cushing B, Slovis T (1992) Imaging of Wilms′ tumour: what is important? Urol Radiol 14: 241–251

    Google Scholar 

  4. de Carmargo B, de Andrea ML, Franco ELF (1987) Catching up with history: treatment of Wilms′ tumour in a developing country. Med Pediatr Oncol 15: 270–276

    Google Scholar 

  5. Eddles M, Hadley GP (1993) A CT assessment of changes associated with pre-operative treatment in Wilms′ tumour. S Afr J Surg 31: 41

    Google Scholar 

  6. Greenberg M, Burnweit C, Filler R et al (1991) Preoperative chemotherapy for children with Wilms′ tumour. J Pediatr Surg 26: 949–956

    Google Scholar 

  7. Hadley GP, Jacobs C (1990) The clinical presentation of Wilms′ tumour in black children. S Afr Med J 77: 565–567

    Google Scholar 

  8. Lemerle J, Tournade MF, Habrand I (1989) The treatment of Wilms′ tumour: An update. Progr Clin Biol Res 303: 629–633

    Google Scholar 

  9. Ng Y, Hall-Craggs M, Dicks-Mireux C et al (1991) Wilms′ tumour: pre and post chemotherapy CT appearances. Clin Radiol 43: 255–259

    Google Scholar 

  10. Nkrumah FK, Danzo AK, Kumar R (1989) Wilms′ tumour (nephroblastoma) in Zimbabwe. Ann Trop Paediatr 9: 89–92

    Google Scholar 

  11. Ritchey ML, Lally KP, Haase GM et al (1992) Superior mesenteric artery injury during nephrectomy for Wilms′ tumour. J Pediatr Surg 27: 612–615

    Google Scholar 

  12. Ritchey ML, Kelalis PP, Breslow N et al (1992) Surgical complications after nephrectomy for Wilms′ tumour. Surg Gynecol Obstet 175: 507–514

    Google Scholar 

  13. Trimble EL, Ungerleider RS, Abrams JA et al (1993) Neoadjuvant therapy in cancer treatment. Cancer [Suppl] 72: 3515–3524

    Google Scholar 

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Authors and Affiliations

  1. Department of Paediatric Surgery, University of Natal, Congella 4013, P. O. Box 17039, Natal, South Africa

    G. P. Hadley

  2. Department of Anaesthetics, University of Natal, Durban, South Africa

    A. T. Bösenberg

Authors
  1. G. P. Hadley
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  2. A. T. Bösenberg
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Hadley, G.P., Bösenberg, A.T. Surgery for Wilms' tumour. Pediatr Surg Int 10, 362–365 (1995). https://doi.org/10.1007/BF00182225

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  • DOI: https://doi.org/10.1007/BF00182225

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