Abstract
The history of bladder exstrophy dates back to 2,000 B.C., there being a reference to this congenital anomaly on an Assyrian tablet preserved in the British Museum. Although there are few references to “non-treatment” of this anomaly in newborns, or for that matter in older infants, there are now an increasing number of references to a wide variety of surgical procedures, and an attempt will be made to trace the historical sequence of many of these. The management of bladder exstrophy continues to advance with the recent advent of early closure, clean intermittent catheterisation, and continent stomas. However, the ability to make a prenatal diagnosis increases the challenge to obtain good cosmetic and functional results. Thus, efforts continue to be made to reliably produce continence, avoid morbidity from herniae, provide a normal umbilicus, and at the same time preserve renal function and achieve a favourable outcome for the genitalia.
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References
Ansell JS (1979) Surgical treatment of exstrophy of the bladder with emphasis on neonatal primary closure: personal experience with 28 consecutive cases treated at the University of Washington Hospitals from 1962 to 1977: technique and results. J Urol 121: 650–653
Barth RA, Filly RA, Sondheimer PK (1990) Prenatal sonographic findings in bladder exstrophy. J Ultrasound Med 9: 359–361
Bassiouny IE (1992) Continent urinary reservoir in exstrophy/epispadias complex. Br J Urol 70: 588–562
Ben-Chaim J, Gearhart JP (1994) Submucosal bladder neck injection of glutaraldehyde cross-linked bovine collagen for treatment of structural incontinence in patients with exstrophy/epispadias. Dial Pediatr Urol 17: 2–3
Borzi PA, Thomas DFM (1994) Cantwell-Ransley epispadias repair in male epispadias and bladder exstrophy. J Urol 151: 457–459
Büyükünal SNC (1994) Interim report in humans of a previously described technique in an animal model: closure of bladder exstrophy with rectus abdominis muscle flap-II. J Urol 152: 706–709
Büyükünal SNC, Kaner G, Celayir S (1989) An alternative treatment modality in closing bladder exstrophy: use of rectus abdominis flap — preliminary results in a rat model. J Pediatr Surg 24: 586–589
Caione P, Lais A, de-Gennaro M, Capozza N (1993) Glutaraldehyde cross-linked bovine collagen in exstrophy/epispadias complex. J Urol 150: 631–633
Campbell S, Wladimiroff JW, Dewhurst CJ (1973) The antenatal measurement of fetal urine production. J Obstet Gynecol Br Com 80: 680–686
Canning DA, Gearhart JP, Peppas DS, Jeffs RD (1993) The cephalotrigonal reimplant in bladder neck reconstruction for patients with exstrophy or epispadias. J Urol 150: 156–158
Cantwell FV (1895) Operative treatment of epispadias by transplantation of the urethra. Ann Surg 22: 689–694
Connor JP, Hensle TW, Lattimer JK, Burbige KA (1989) Long-term follow-up of 207 patients with bladder exstrophy: an evolution in treatment. J Urol 142: 793–796
Cook FE, Leslie JT, Brannon EW (1962) Preliminary report: a new concept of abdominal closure in infants with exstrophy of the bladder. J Urol 87: 823–824
Criado E, Mesrobian HG, Bethea MC, Azizkhan RG (1992) Heterotopic hindgut duplication: a cloacal remnant associated with exstrophy of the bladder. J Pediatr Surg 27: 1605–1607
Csontai A, Merksz M, Pirot L, Toth J (1992) Results of surgical treatment in children with bladder exstrophy. Br J Urol 70: 683–685
De Castro R, Pavanello P, Domini R (1994) Indications for bladder augmentation in the exstrophy complex. Br J Urol 73: 303–307
De la Hunt MN, O'Donnell B (1989) Current management of bladder exstrophy: a BAPS collective review from eight centres of 81 patients born between 1975 and 1985. J Pediatr Surg 24: 584–585
Dees JE (1949) Congenital epispadias with incontinence. J Urol 62: 513–522
Dewan PA (1995) Umbilical transposition in neonates with bladder exstrophy. Br J Urol (in press)
Dewan PA, Nicholls EA, Goh DW (1994) Ureterocystoplasty: an extraperitoneal, urothelial bladder augmentation technique. Eur Urol 26: 85–89
Dewan PA, Stefanek W (1994) Autoaugmentation gastrocystoplasty: early clinical results. Br J Urol 74: 460–464
Dewan PA, Stefanek W (1994) Autoaugmentation colocystoplasty: a case report. Pediatr Surg Int 9: 526–528
Diamond DA, Ransley PG (1986) Bladder neck reconstruction with omentum, silicone, and augmentation cystoplasty — a preliminary report. J Urol 136: 252–255
Duckett JW (1977) Use of paraexstrophy skin pedicle flaps for correction of exstrophy and epispadias repair. Birth Defects 13: 175
Duckett JW (1980) Transverse preputial island flap technique for repair of severe hypospadias. Urol Clin North Am 7: 423–431
Duckett JW, Caldamone AA (1985) Anomalies of the urinary tract: bladder and urachus. In: King LR, Kelalis PP, Belman AB (eds) Clinical pediatric urology. WB Saunders, pp 725–751
Duckett JW, Lofti A (1993) Appendicovesicostomy (and variations) in bladder reconstruction. J Urol 149: 567–569
Duplay S (1880) Sur le traitement chirurgical de l'hypospadias et de l'épispadias. Arch Gén Méd 5: 257–274
Engel RM, Wilkinson HA (1970) Bladder exstrophy. J Urol 104: 699–704
Filmer RB, Spencer JR (1990) Malignancies in bladder augmentations and intestinal conduits. J Urol 143: 671–678
Frey P, Cohen SJ (1989) Anterior pelvic osteotomy. A new operative technique facilitating primary bladder exstrophy closure. Br J Urol 64: 641–643
Ganesan GS, Nguyen DH, Adams MC, King SJ, Rink RC, Burns MW, Mitchell ME (1993) Lower urinary tract reconstruition using stomach and the artificial sphincter. J Urol 149: 1107–1109
Gardiner RA (1994) The invaginated sleeve technique for a continent cystostomy — five years' clinical experience. Br J Urol 73: 35–39
Gearhart JP, Leonard MP, Burgers JK, Jeffs RD (1992) The Cantwell-Ransley technique for the repair of epispadias. J Urol 148: 851–854
Gearhart JP, Peppas DS, Jeffs RD (1993) Complications of paraexstrophy skin flaps in the reconstruction of classical bladder exstrophy. J Urol 150: 627–630
Gearhart JP, Peppas DS, Jeffs RD (1993) Complete genitourinary reconstruction in female epispadias. J Urol 149: 1110–1113
Gibbon AJ Maffulli N, Fixsen JA (1991) Horizontal pelvic osteotomies for bladder exstrophy. A preliminary report. J Bone Joint Surg 73: 806–808
Gonzalez R, Koleilat N, Austin C, Sidi AA (1989) The artificial sphincter AS800 in congenital urinary incontinence. J Urol 142: 512–515
Hanna MK (1986) Reconstruction of umbilicus during functional closure of bladder exstrophy. Urol 27: 340–342
Hanna MK, Ansong K (1984) Reconstruction of umbilicus in bladder exstrophy. Urol 24: 324–326
Hendren WH (1979) Penile lengthening after previous repair of epispadias. J Urol 121: 527–534
Hendren WH (1980) Construction of the female urethra from vaginal wall and perineal flap. J Urol 123: 657–664
Hollowell JG, Ransley PG (1991) Surgical management of incontinence in bladder exstrophy. Br J Urol 68: 543–548
Husmann DA, McLorie GA, Churchill BM (1990) Factors predisposing to renal scarring following staged reconstruction of classical bladder exstrophy. J Pediatr Surg 25: 500–504
Husmann DA, McLorie GA, Churchill BM (1990) Inguinal pathology and its association with classical bladder exstrophy. J Pediatr Surg 25: 332–334
Husmann DA, Spence HM (1990) Current status of tumor of the bowel following ureterosigmoidostomy: a review. J Urol 144(3): 607–610
Jaffe R, Schoenfeld A, Ovadia J (1990) Sonographic findings in the prenatal diagnosis of bladder exstrophy. Am J Obstet Gynecol 162: 675–678
Jeffs RD (1986) Exstrophy of the urinary bladder. In: Welch KJ, Randolph JG, Ravitch MM, O'Neill JA, Rowe MI (eds) Pediatric surgery. Year Book Medical Publishers, Chicago, pp 1216–1240
Jeffs RD, Guice SL, Oesch I (1982) The factors in successful exstrophy closure. J Urol 127: 974–976
Kelly JH, Eraklis AJ (1971) A procedure for lengthening the phallus in boys with exstrophy of the bladder. J Pediatr Surg 6: 645–649
Khara B, Bowditch JDP (1994) Conception, pregnancy and delivery without a sexually functional vagina following corrective surgery of ectopia vesicae. Aust N Z J Obstet Gynecol 34: 611–613
Koff SA (1990) A technique for bladder neck reconstruction in exstrophy: the cinch. J Urol 144: 546–549
Koff SA, Eakins M (1984) The treatment of penile chordee using corporeal rotation. J Urol 131: 931–932
Krisiloff M, Puchner PJ, Tretter W, Macfarlane MT, Lattimer JK (1978) Pregnancy in women with bladder exstrophy. J Urol 119: 478–479
Kroovand RL (1991) Artificial urinary sphincter implantation. Dial Pediatr Urol 14: 5–6
Kropp KA (1991) Management of urethral incompetence in the patient with a neurogenic bladder. Dial Pediatr Urol 14: 6–7
Lapides J, Diokno AC, Gould FR, Lowe BS (1976) Further observations on self-catheterization. J Urol 116: 169–171
Lapides J, Diokno AC, Silber SJ, Lowe BS (1972) Clean, intermittent, self-catheterization in the treatment of urinary tract disease. J Urol 107: 458–461
Leadbetter GW (1964) Surgical correction of total urinary incontinence. J Urol 91: 261–266
Leonard MP, Gearhart JP, Jeffs RU (1990) Continent urinary reservoirs in pediatric urological practice. J Urol 144: 330–333
Lepor H, Jeffs RD (1983) Primary bladder closure and bladder neck reconstruction in classical bladder exstrophy. J Urol 130: 1142–1145
Light JK, Scott FB (1983) Treatment of the epispadias-exstrophy complex with the AS792 artificial urinary sphincter. J Urol 129: 738–740
Lima SVC, Noróes JAA, Carvalheria F, de Mendonça PP (1981) Bladder exstrophy. Primary reconstruction with human dura mater. Br J Urol 53: 119–124
Loder RI, Dayioglu MM (1990) Association of congenital vertebral malformations with bladder and cloacal extrophy. J Pediatr Orthop 10: 389–393
Marshall VF, Muecke EC (1970) Functional closure of typical extrophy of the bladder. J Urol 104: 205–212
Meguerian PA, McLorie GA, McMullin ND, Khoury AE, Hustmann DA, Churchill BM (1991) Continence in bladder extrophy: determinants of success. J Urol 145: 350–352
Mesrobian H-GJ, Kelalis PP, Kramer SA (1988) Long-term follow-up of 103 patients with bladder exstrophy. J Urol 139: 719–722
Michon L (1984) Conservative operations for exstrophy of the bladder, with particular reference to urinary incontinence. Br J Urol 20: 167
Mikulicz J (1899) Zur Operation der angeborenen Blasenspalte. Zentralbl Chir 26: 641–643
Mirk P, Calisti A, Fileni A (1986) Prenatal diagnosis of bladder exstrophy. J Ultrasound Med 5: 291–293
Mitrofanoff P (1980) Cystotomie continente trans-appendiculaire dans le traitement des vessies neuroloques. Chir Pédiatr 21: 297–305
Mollard P (1980) Bladder reconstruction in exstrophy. J Urol 124: 525–529
Mollard P, Mouriquand PDE, Buttin X (1994) Urinary continence after reconstruction of classical bladder exstrophy (73 cases). Br J Urol 73: 298–302
Monfort G, Morisson G, Guys JM, Coquet M (1987) Transverse island flap and double flap in the treatment of congenital epispadias in 32 patients. J Urol 138: 1069–1071
Mortensen PB, Jensen KEJ, Nielsen K (1990) Adenocarcinoma development in the trigone 34 years after trigonocolonic urinary diversion for exstrophy of the bladder. J Urol 144: 980–982
Nesbit RM (1965) Congenital curvature of the phallus: report of three cases with description of corrective operation. J Urol 93: 230–233
Oelrich TM (1980) The urethral sphincter muscle in the male. Am J Anat 158: 229–246
Oesterling JE, Jeffs RD (1987) The importance of a successful initial bladder closure in the surgical management of classical bladder exstrophy: analysis of 144 patients treated at the Johns Hopkins Hospital between 1975 and 1985. J Urol 137: 258–262
Perlmutter AD, WSinstein MD, Reitelman C (1991) Vesical neck reconstruction in patients with epispadias-exstrophy complex. J Urol 146: 613–615
Perovic S, Brdar R, Scepanovic D (1992) Bladder exstrophy and anterior pelvic osteotomy. Br J Urol 70: 678–682
Perovic S, Scepanovic D, Sremcevic D, Vukadinovic V (1992) Epispadias surgery — Belgrade experience. Br J Urol 70: 647–677
Phillips TH, Ritchey ML, Dunn CD, Sarosdy MF (1991) Complications of the Heitz-Boyer urinary diversion: case report of late development of malignancy. J Urol 146: 159–161
Rutkowski M (1899) Zur Methode der Harnblasenplastik. Zentralbl Chir 16: 473–478
Scherz HC, Kaplan GW, Sutherland DR, Packer MG (1990) Fascia lata and early spica casting as adjuncts in closure of bladder exstrophy. J Urol 144: 550–553
Schmidt Ah, Keenen TL, Tank ES, Bird CB, Beals RK (1993) Pelvic osteotomy for bladder exstrophy. J Pediatr Orthop 13: 214–219
Schultz WG (1958) Plastic repair of exstrophy of bladder combined with bilateral osteotomy of ilia. J Urol 79: 453–458
Segura JW, Kelalis PP (1975) Long-term results of ureterosigmoidostomy in children with bladder exstrophy. J Urol 114: 138–140
Shapiro SR, Lebowitz R, Colodny AH (1975) Fate of 90 children with ileal conduit diversion a decade later. J Urol 114: 289–295
Simon J (1952) Ectopia vesicae (absence of the anterior walls of the bladder and public abdominal parietes); operation for directing the orifices of the ureters into the rectum; temporary success; subsequent death; autopsy. Lancet II: 568–570
Simon J (1955) Congenital imperfication of the urinary organs treated by operation. Trans Pathol Soc Lond 6: 256–258
Snyder HM (1990) The surgery of bladder exstrophy and epospadias. In: Frank JD, Johnson JH (eds) Operative paediatric urology. Churchill Livingstone, Edinburgh, pp 153–185
Sponseller PD, Gearhart JP, Jeffs RD (1991) Anterior innominate osteotomies for failure or late closure of bladder exstrophy. J Urol 146: 137–140
Strachan JR, Woodhouse CR (1991) Malignancy following ureterosigmoidostomy in patients with exstrophy. Br J Surg 78: 1216–1218
Stringer MD, Duffy PG, Ransley PG (1994) Inguinal hernias associated with bladder exstrophy. Br J Urol 73: 308–309
Sumfest JM, Bruns MW, Mitchell ME (1993) The Mitrofanoff principle in urinary reconstruction. J Urol 150: 1875–1878
Sumfest JM, Mitchell ME (1994) Reconstruction of the umbilicus in exstrophy. J Urol 151: 453–454
Swenson O (1957) Changong trends in the management of exstrophy of the bladder. Surgery 42: 61–66
Thiersch C (1969) Ueber die Enststehungsweise und operative Behandlung der Epispadie. Arch Heilkunde 10: 20
Trendelenburg F (1906) The treatment of ectopia vesiae. Ann Surg 44: 281–289
Vyas PR, Roth DR, Perlmutter AD (1987) Experience with free grafts in urethral reconstruction. J Urol 137: 471–474
Weiss RE, Garden RJ, Cohen EL, Stone NN (1993) Covered exstrophy with suquestered colonic remnant. J Urol 150: 185–187
Williams DI (1974) Epispadias and exstrophy. In: Encyclopedia of urology. Supplement 15: urology in childhood. Springer, Berlin Heidelberg New York, pp 270–279
Woodhouse CRJ (1986) The management of erectile deformity in adults with exstrophy and epispadias. J Urol 135: 932–935
Woodhouse CRJ, Gordon EM (1994) The Mitrofanoff principle for urethral failure. Br J Urol 73: 55–60
Woodhouse CRJ, Kellett MJ (1984) Anatomy of the penis and its deformities in exstrophy and epispadias. J Urol 132: 1122–1124
Woodhouse CRJ, Malone PR, Cumming J, Reilly TM (1989) The Mitrofanoff principle for continent urinary diversion. Br J Urol 63: 53–57
Woodhouse CRJ, Ransley PG, Williams DI (1983) The exstrophy patient in adult life. Br J Urol 55: 632–635
Young HH (1919) An operation for the cure of incontinence of urine. Surg Gynecol Obstet 28: 84–90
Young HH (1942) Exstrophy of the bladder: the first case in which a normal bladder urinary control have been obtained by plastic operation. Surg Gynecol Obstet 74: 729–737
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Dewan, P.A. Historical trends in the management of bladder exstrophy. Pediatr Surg Int 10, 289–297 (1995). https://doi.org/10.1007/BF00182206
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DOI: https://doi.org/10.1007/BF00182206