Abstract
Between 1954 and 1985, 15 cases of malignant sacrococcygeal teratoma were treated in our institution. Median age at presentation was 20 months (range 9–46 months); there were 14 females and 1 male. Six cases presenting prior to 1970 were treated without chemotherapy with a median survival of 2 months (range 1–7 months). Five patients treated from 1971 to 1979 had tumour excision plus vincristine, actinomycin D, and cyclophosphamide (VAC). Three received radiotherapy in addition and median survival was 11 months (range 0–31 months). Four patients presenting since 1980 had chemotherapy alone after tumour excision. 1 receiving VAC and adriamycin and the remaining patients cisplatinum, bleomycin, and VP16. All these are alive and disease free (median follow-up 27 months; range 15–96 months). It is concluded that initial surgery aimed at complete excision followed by aggressive chemotherapy gives good results.
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References
Altman RP, Randolph JG, Lilly JR (1974) Sacrococcygeal teratoma: American Academy of Pediatrics surgical section survey 1973. J Pediatr Surg 9: 389–398
Billmire DF, Grosfeld JL (1986) Teratomas in childhood: analysis of 142 cases. J Pediatr Surg 21: 548–551
Birch JM, Marsden HB, Jones PM, Pearson D, Blair V (1988) Improvements in survival from childhood cancer: results of a population based survey over 30 years. Br Med J 296: 1372–1376
Chretien PB, Milam JD, Foote FW, Miller TR (1970) Embryonal adenocarcinomas (a type of malignant teratoma) of the sacrococcygeal region. Cancer 26: 522–535
Dewan P, Davidson PM, Campbell PE, Tiedemann K, Jones PG (1987) Sacrococcygeal teratoma: has chemotherapy improved survival? J Pediatr Surg 22: 274–277
Ein SH, Mancer K, Adeyemi SD (1985) Malignant sacrococcygeal teratoma — endodermal sinus, yolk sac tumor —in infants and children: a 32-year review. J Pediatr Surg 20: 473–477
Gitlin D, Perricelli A, Gitlin GM (1972) Synthesis of alpha-fetoprotein by liver, yolk sac and gastrointestinal tract of the human conceptus. Cancer Res 32: 979–984
Grisoni ER, Gauderer MWL, Wolfson RN, Jassani MN, Olsen MM (1988) Antenatal diagnosis of sacrococcygeal teratomas: prognostic features. Pediatr Surg Int 3: 173–175
Jones PM (1987) Advances in managing childhood cancer. Br Med J 295: 4–6
Mackinnon AE, Cohen SJ (1978) Archenteronoma (yolk sac tumors). J Pediatr Surg 13: 21–23
Marsden HB, Birch JM, Swindell R (1981) Germ cell tumors of childhood: a review of 137 cases. J Clin Pathol 34: 879–883
Noseworthy J, Lack EE, Kozakewich HPW, Vawter GF, Welch KJ (1981) Sacrococcygeal germ cell tumors in childhood: an updated experience with 118 patients. J Pediatr Surg 16: 358–364
Olsen MM, Raffensperger JG, Gonzalez-Crussi F, Luck SR, Kaplan WE, Morgan ER (1982) Endodermal sinus tumor: a clinical and pathologic correlation. J Pediatr Surg 17: 833–840
Raney BR, Chatten J, Littman P, Jarrett P, Schnaufer L, Bishop H, D'Angio J (1981) Treatment strategies for infants with malignant sacrococcygeal teratoma. J Pediatr Surg 16: 573–577
Smith B, Passaro E, Clatworthy HW (1961) The vascular anatomy of sacrococcygeal teratomas: its significance in surgical management. Surgery 49: 534–539
Tsuchida Y, Endo Y, Saito S. Kaneko M, Shiraki K, Ohmi K (1978) Evaluation of alpha-fetoprotein in early infancy. J Pediatr Surg 13: 155–156
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Shanbhogue, L.K.R., Gough, D.C.S. & Jones, P.M. Malignant sacrococcygeal teratoma: improved survival with chemotherapy. Pediatr Surg Int 4, 202–204 (1989). https://doi.org/10.1007/BF00181986
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DOI: https://doi.org/10.1007/BF00181986