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European Archives of Oto-Rhino-Laryngology

, Volume 251, Issue 7, pp 423–427 | Cite as

Tonsillectomy and the immune system: a long-term follow up comparison between tonsillectomized and non-tonsillectomized children

  • A. Böck
  • W. Popp
  • K.R. Herkner
Original Paper

Abstract

Immunological functions of the tonsils and possible effects of their removal are still controversial. One reason for this is the lack of long-term follow-up investigations after tonsillectomy. In the present study selected parameters of the cellular and Immoral immune systems of 160 children 0.5–11 years after tonsillectomy (mean 6.6 ± 2.1 years) were compared to those of 302 age-matched non-tonsillectomized children. In tonsillectomized children the incidence of infections of the upper respiratory tract was not increased compared to the non-tonsillectomized control group. Slightly increased percentages of CD 21+ cells, raised counts of CD4+ cells, absolute and relative increases in DR+ cells and a raised CD4+ DR count was found mainly in tonsillectomized boys, while lymphocyte subpopulations of tonsillectomized girls remained unaffected. Tonsillectomized children had lower IgA levels, but the complement system was not altered in either sex. These findings show that while tonsillectomy may lead to certain changes in the cellular and humoral immune systems, these alterations are clinically insignificant and no increased frequency of immunomodulated diseases should be expected.

Key words

Tonsillectomy Immune system Immunomodulated diseases 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • A. Böck
    • 1
  • W. Popp
    • 2
  • K.R. Herkner
    • 3
  1. 1.Department of PediatricsUniversity HospitalViennaAustria
  2. 2.Department of PulmonologyHospital LainzViennaAustria
  3. 3.Ludwig Boltzmann Institute for Pediatric Endocrinology and ImmunologyUniversity HospitalViennaAustria

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