Abstract
Blood selenium concentrations in 43 patients with laryngeal cancer and 47 normal subjects were determined by atomic absorption spectrophotometry. No significant differences in selenium values were observed in sera from the cancer patients when compared with controls, but there were significant differences between patients with advanced (T4) supraglottic cancers and the normal controls. These results suggest that lower blood selenium levels in this latter group of laryngeal cancer patients may be a consequence of their disease rather than its cause.
Similar content being viewed by others
References
Behne D, Hofer-Bosse T (1984) Effects of a low selenium status on the distribution and retention of selenium in the rat. J Nutr 114:1289–1296
Broghamer WL, McConnell KP, Grimaldi M, Blotcky AJ (1978) Serum selenium and reticuloendothelial tumors. Cancer 41:1462–1466
Buljevac M (1991) Blood selenium concentration in patients with higher risk of developing carcinoma. Doctorate, University of Zagreb
Cavalier RR (1966) Selenite 75Se as a tumor-localizing agent in man. J Nucl Med 7:187–199
Cowgill UM (1983) The distribution of selenium and cancer mortality in the continental United States. Biol Trace Element Res 5:345–361
Frolov AG (1990) The effect of sodium selenite on the butyl butanol nitrosamine induction of bladder tumors in rats. Vopr Onkol 36:697–700
Griffin AC (1979) Role of selenium in the chemoprevention of cancer. Adv Cancer Res 29:419–443
Hara T (1973) Production of 75Se in cyclotron and its uptake in tumors of mice. Int J Appl Radiat Isot 24: 377–378
Jacobson BE, Lockitch G (1988) Direct determination of selenium in serum by graphite-furnace atomic absorption spectrometry with deuterium background correction and reduced palladium modifier: age specific ranges. Clin Chem 34:709–714
Jansson B (1980) The role of selenium as a cancer protecting trace element. In: Sigel H (ed) Metal ions in biological systems. Dekker, New York, pp 281–311
McConnell KP, Broghamer WL, Blotcky AJ, Hurt OJ (1975) Selenium levels in human blood and tissues in health and in disease. J Nutr 105:1026–1031
Pallini V, Bacci E (1979) Bull sperm is bound to a structural protein of mitochondria. J Submicrosc Cytol 11:165–170
Rea HM, Thomson CD, Campbell DR, Robinson MF (1979) Relation between erytrocyte selenium concentrations and glutathione peroxidase activities of New Zealand residents and visitors to New Zealand. Br J Nutr 42:201–210
Robinson MF, Godfrey JP, Thomson CD, Rea HM, Van Rij AM (1979) Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand. Am J Clin Nutr 32:1477–1485
Rotruck JP, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588–590
Roy D, Liehr JG (1990) Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism. Carcinogenesis 11:567–570
Salonen JT, Alfthan G, Huttunen JK, Puska P (1984) Association between serum selenium and the risk of cancer. Am J Epidemiol 120:342–349
Salonen JT, Salonen R, Lappetelainen R, Maenpaa PH, Alfthan G, Puska P (1985) Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case control analysis of prospective data. BMJ 290:417–420
Shamberger RJ, Willis CE (1971) Selenium distribution and human cancer mortality. CRC Crit Rev Clin Lab Sci June 211–221
Tjorling EB, Overvad G, Begoers J (1986) Selenium status in Europe-human data. A multicentric study. Ann Clin Res 18:3–7
Virtamo J, Valkeila E, Alfathan G, Pusnar S, Huttunen J, Karvonen MJ (1987) Serum selenium and risk of cancer, a prospective follow-up of nine years. Cancer 60:145–148
Vukelic N (1988) Selenium concentration in serum and urine in patients with carcinoma of digastric organs. Doctorate, University of Zagreb
Wallace E (1984) Functional and developmental studies on the role of selenium in spermatogenesis. In: Combs GF, Spallholz JE, Levander OA, Oldfield JE (eds) Selenium in biology and medicine, part A, Van Nostrand Reinhold, New York, pp 181–197
Willet WC, Morris JS, Pressel S (1983) Prediagnostic serum selenium and risk of cancer. Lancet 11:130–134
Yang R, Huang J, Feng G, Mei Z (1990) Blood selenium levels in nasopharyngeal cancer patients in south China. Med Lab Sci 47:132–134
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lajtman, Z., Nosso, D., Romic, Z. et al. Laryngeal cancer and blood selenium levels. Eur Arch Otorhinolaryngol 251, 170–172 (1994). https://doi.org/10.1007/BF00181830
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00181830