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Radioimmunoscintigraphy with technetium-99m labelled monoclonal antibody, 1A3, in colorectal cancer

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Abstract

This study of radioimmunoscintigraphy (RIS) was primarily undertaken to determine how the imaging results related to surgical findings. Technetium-99m radiolabelled 1A3, a monoclonal antibody against a columnar cell surface antigen, was used. No adverse effects or thyroid uptake was observed in 127 studies. The 85 primary colorectal cancers were all image positive. In the assessment of recurrent tumour in the abdomen or pelvis, the accuracy was 33/35 (94%), including true-positive findings in some whose serum carcinoembryonic antigen was normal. There was a positive predictive value for abdominal or pelvic recurrence of 92% and a negative predictive value of 100%, at a prevalence of 66%. In those patients whose liver was able to be evaluated, the accuracy was 72/79 (91%). There was a positive predictive value for liver metastases of 88% and a negative predictive value of 93%, at a prevalence of 32%. The simple procedure for labelling antibody with 99mTc and its ready availability allow a completed report to be given within 24 h of the request.

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References

  1. Fischman AJ, Khaw BA, Strauss HW. Quo vadis radioimmune imaging. N Nucl Med 1989; 30:1911–1313.

    Google Scholar 

  2. Pauwels EKJ, Van Kroonenburgh MJPG. Prospects for radioimmunoimaging in oncology? Nucl Med Commun 1988; 9:867–869.

    Google Scholar 

  3. Epenetos AA, Britton KE, Mather S et al. Targeting of iodine-123 labelled tumour-associated monoclonal antibodies to ovarian, breast and gastrointestinal tumours. Lancet 1982; 11:999–1005.

    Google Scholar 

  4. Buraggi GL, Turrin A, Cascinelli N et al. Immunoscintigraphy with antimelanoma monoclonal antibodies. In: Donato L, Britton KE, eds. Monographs in nuclear medicine, vol I. Immunoscintigraphy. Proceedings of the European Symposium on Immunoscintigraphy, Saariselka, Finland 1983. New York: Gordon & Breech; 1984:215–253.

    Google Scholar 

  5. Granowska M, Britton KE, Shepherd J. The detection of ovarian cancer using 123–1 monoclonal antibody. Radiobiol Radiother (Berl) 1983; 25:153–160.

    Google Scholar 

  6. Berche C, Mach J-P, Lumbroso JD, et al. Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: first clinical results using radiolabelled monoclonal antibodies against carcinoembryonic antigens. Br Med J 1982; 285:1447–1451.

    Google Scholar 

  7. Britton KE, Granowska M, Mather S, Nimmon CC. Experience with 123-I labelled monoclonal antibodies. In: Donato L, Britton KE, eds. Monographs in nuclear medicine, vol I. Immunoscintigraphy. Proceedings of the European Symposium on Immunoscintigraphy, Saariselka, Finland 1983. New York: Gordon & Breech; 1984:51–66.

    Google Scholar 

  8. Britton KE, Granowska M. Radioimmunoscintigraphy in tumour identification. Cancer Surv 1987; 6:247–267.

    Google Scholar 

  9. Britton KE, Granowska M. Experience with iodine-123 labelled antibodies. In: Srivastava SC, ed. Radiolabelled monoclonal antibodies for imaging and therapy. NATO ASI Series A, Life Sciences 152. New York: Pergamon; 1988:177–191.

    Google Scholar 

  10. Granowska M, Nimmon CC, Britton KE, et al. Kinetic analysis and probability mapping applied to the detection of ovarian cancer by radioimmunoscintigraphy. J Nucl Med 1988;29:599–607.

    Google Scholar 

  11. Bares R, Fass J, Buell V, Schumpelik V. Validity of tomographical methods for radioimmunodetection of gastrointestinal tumours. In: Klapdor R, ed. New tumour markers and their monoclonal antibodies. Stuttgart: Georg Thieme; 1987:470–474.

    Google Scholar 

  12. Perkins AC, Whalley DR, Ballantyne KC, Pimm MV Gamma camera emission tomography using radiolabelled antibodies. Eur J Nucl Med 1988; 14:45–49.

    Google Scholar 

  13. Rhodes BA, Burchiel SW. Radiolabelling of antibodies with technetium-99m. In: Burchiel SW, Rhodes BA, eds. Radioimmunoimaging. New York: Elsevier Science; 1983:207–222.

    Google Scholar 

  14. Buraggi GL,Callegaro L, Turrin A, et al. Immunoscintigraphy with 1–123, Tc-99m & In-111 F(ab')2 fragments of monoclonal antibodies to a high molecular weight melanoma associated antigen. J Nucl Med Allied Sci 1984; 28:283–295.

    Google Scholar 

  15. Siccardi AG, Buraggi GL, Callegaro L, et al. Multicentre study of immunoscintigraphy with radiolabelled monoclonal antibodies in patients with melanoma. Cancer Res 1986; 46:4817–4822.

    Google Scholar 

  16. Schwarz A, Steinstrasser A. A novel approach to Tc-99m-labelled monoclonal antibodies [abstract]. J Nucl Med 1987; 28:721.

    Google Scholar 

  17. Eckelman WC, Paik CH, Steigman J. Three approaches to radiolabeling with 99mTc. Nucl Med Biol 1989; 171–176.

  18. Mather SJ, Ellison D. Reduction-mediated technetium-99m labeling of monoclonal antibodies. J Nucl Med 1990; 31:692–697.

    Google Scholar 

  19. Goldenberg DM, Kim EE, Deland FH, et al. Radio-immunodetection of cancer with radioactive antibodies to carcino-embryonic antigen. Cancer Res 1980; 40:2984–2992.

    Google Scholar 

  20. Mach LP, Carrel S, Forni M. Tumour localisation of radiolabelled antibodies against carcino-embryonic antigen in patients with carcinoma. N Engl J Med 1980; 303:5–10.

    Google Scholar 

  21. Chatal J-F, Saccavini JC, Furnoleau P, et al. Immunoscintigraphy of colon carcinoma. J Nucl Med 1984; 25:307–314.

    Google Scholar 

  22. Granowska M, Jass JR, Britton KE, Northover JMA. A prospective study of the use of 111In-labeled monoclonal antibody against carcino-embryonic antigen in colorectal cancer and of some biological factors affecting its uptake. Int J Colorectal Dis 1989; 4:97–108.

    Google Scholar 

  23. Baum RP, Hertel A, Lorenz M, et al. 99mTc-labelled anti-CEA monoclonal antibody for tumour immunoscintigraphy: first clinical results. Nucl Med Commun 1989; 10:345–348.

    Google Scholar 

  24. Richman PI, Bodmer WF. Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization. Int J Cancer 1987; 39:317–328.

    Google Scholar 

  25. Beatty JD, Duda RB, Williams L, et al. Preoperative imaging of colorectal carcinoma with 111-In-labelled anticarcinoembryonic antigen monoclonal antibody. Cancer Res 1986; 46:6494–6502

    Google Scholar 

  26. Granowska M, Richman P, Britton KE et al. A new monoclsonal antibody for radioimmunoscintigraphy, RIS, of colorectal cancer: PR1A3 labelled with indium-111. In: Schmidt HAE, Buraggi GL, eds. Nuclear medicine trends and possibilities. Proc Eur Nucl Med Cong, Milan. Stuttgart: Schattauer; 1989:531–534.

    Google Scholar 

  27. Granowska M, Mather SJ, Britton KE. A Tc-99m-labeled monoclonal antibody, PR1A3, for radioimmunoscintigraphy, RIS, of colorectal cancer [abstract]. J Nucl Med 1989; 30:748

    Google Scholar 

  28. Dukes CE. The classification of cancer of the rectum. J Pathol Bacteriol 1932; 35:323–332.

    Google Scholar 

  29. Day DW, Morson BC. The adenoma carcinoma sequence. In: Morson BC, ed. The pathogenesis of colorectal cancer. Philadelphia: Saunders;1978:48–61.

    Google Scholar 

  30. Granowska M, Mather SJ, Britton KE, et al. 99mTc radioimmunoscintigraphy of colorectal cancer. Br J Cancer 1990; 62 Suppl X:30–33.

    Google Scholar 

  31. Granowska M, Mather SJ, Britton KE. Diagnostic evaluation of 111In and 99mTc radiolabelled monoclonal antibodies in ovarian and colorectal cancer: correlations with surgery. Nucl Med Biol 1991; 18:413–424.

    Google Scholar 

  32. Lind P, Langsteger W, Koltringer P, et al. Immunoscintigraphy with Tc-99m labelled monoclonal anti-CEA antibodies (BW 431/26) in the follow up of patients with colorectal carcinomas. In: Schmidt HAE, Chambron J, eds. Nuclear medicine quantitative analysis in imaging and function. Proceedings of the European Association of Nuclear Medicine Congress, Strasbourg. Stuttgart: Schattauer; 1989:567–569.

    Google Scholar 

  33. Pinsky CM, Goldenberg DM, Wlodkowski TJ, et al. Detection of occult metastases of colorectal cancer by the use of anti-CEA Fab' fragments labelled with Tc-99m [abstract]. J Nucl Med 1991; 32:1052.

    Google Scholar 

  34. Kuhn JA, Corbisiero RM, Buras RR, et al. Intraoperative gamma detection probe with presurgical antibody imaging in colon cancer. Arch Surg 1991; 126:1398–1403.

    Google Scholar 

  35. Britton KE, Buraggi GL. A brief guide to the practice of radioimmunoscintigraphy and radioimmunotherapy in cancer. Int J Biol Markers 1989; 4:106–118.

    Google Scholar 

  36. Britton KE, Granowska M, Mather SJ. Radiolabelled monoclonal antibodies in oncology 1. Technical Aspects. Nucl Med Commun 1991; 12:65–76.

    Google Scholar 

  37. Chatal J-F, Peltier P, Bardies M, et al. Does immunoscintigraphy serve clinical needs effectively? Eur J Nucl Med 1992; 19:205–213.

    Google Scholar 

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Authors and Affiliations

  1. St. Mark's Hospital, Imperial Cancer Research Fund Unit, City of London, UK

    M. Granowska, K. E. Britton, S. J. Mather, G. Morris, D. Ellison, S. Soobramoney, I. C. Talbot & J. M. A. Northover

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  1. M. Granowska
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  2. K. E. Britton
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  3. S. J. Mather
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  4. G. Morris
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  5. D. Ellison
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  6. S. Soobramoney
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  7. I. C. Talbot
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  8. J. M. A. Northover
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Granowska, M., Britton, K.E., Mather, S.J. et al. Radioimmunoscintigraphy with technetium-99m labelled monoclonal antibody, 1A3, in colorectal cancer. Eur J Nucl Med 20, 690–698 (1993). https://doi.org/10.1007/BF00181760

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  • DOI: https://doi.org/10.1007/BF00181760

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