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Reproducibility of coronary calcification detection with electron-beam computed tomography

  • Cardiovascular Radiology
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Abstract

If coronary calcification scores obtained with electron-beam computed tomography (EBT) were proved to be correlated to coronary atherosclerosis, the reproducibility of the technique had to be assessed before being used for patient follow-up. A total of 150 patients, selected as a result of a cholesterol screening programme, were studied by EBT. Twelve contiguous 3-mm-thick transverse slices beginning on the proximal coronary arteries were obtained through the base of the heart. The amount of calcium was evaluated as the calcified area weighted by a coefficient depending on the density peak level. The value was expressed as a logarithmic scale. Intra-observer, inter-observer and inter-examination reproducibilities were calculated. They were 1.9, 1.3 and 7.2%, respectively. These results were good enough to allow the use of EBT for longitudinal studies. The influence of acquisition and calculation conditions on score computation were also analyzed.

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References

  1. Tampas JPK, Soule AB, Taylor HC (1968) Coronary artery calcification: its relationship to coronary artery stenosis and myocardial infarction. Radiology 91: 109–115

    Google Scholar 

  2. McCarthy JF, Palmer FJ (1974) The incidence and significance of coronary artery calcification. Br Heart J 36: 499–506

    Google Scholar 

  3. margolis JR, Chen JTT, Kong Y, Peter RH, Behar VS, Kisslo JA (1980) The diagnostic and prognostic significance of coronary artery calcification. Radiology 137: 609–616

    Google Scholar 

  4. Enos WF, Holmes RH, Berger J (1953) Coronary disease among United States soldiers killed in action in Korea. JAMA 52: 1090–1093

    Google Scholar 

  5. McNamara JJ, Molot MA, Stremple JF, Cutting RT (1971) Coronary artery disease in combat casualties in Vietnam. JAMA 216: 1185–1187

    Google Scholar 

  6. Hamby RI, Tabrah F, Wisoff BG, Harstein MI (1974) Coronary calcification: clinical implications and angiographic correlates. Am Heart J 87: 565–570

    Google Scholar 

  7. Bartel AG, Chen JT, Peter RH, Behar VS, Kong Y, Lester RG (1974) The signifance of coronary calcification detected by fluoroscopy. Circulation 49: 1247–1253

    Google Scholar 

  8. Rifkin RD, Parisi AF, Folland E (1979) Coronary calcification in the diagnosis of coronary artery disease. Am J Cardiol 44: 141–147

    Google Scholar 

  9. Detrano R, Salcedo EE, Hobbs RE, Yiagnikas J (1986) Cardiac cine fluoroscopy as an inexpensive aid in the diagnosis of coronary artery disease. Am J Cardiol 57: 1041–1046

    Google Scholar 

  10. Detrano R, Markovic D, Simpfendorfer C et al (1985) Digital subtraction fluoroscopy: a new method of detecting coronary calcification with improved sensitivity for the prediction of coronary disease. Circulation 71: 725–732

    Google Scholar 

  11. Rifkin RD, Uretsky BF (1993) Screening for latent coronary artery disease by fluoroscopic detection of calcium in the coronary arteries. Am J Cardiol 44: 141–147

    Google Scholar 

  12. Markivee C, Hoyt T, Francis R, Burns J, Ruark B (1984) Gated cardiac tomographic visualization of coronary artery calcification. Radiology 152: 205–206

    Google Scholar 

  13. Reinmuller R, Lipton MJ (1987) Detection of coronary artery calcium by computed tomography. Dyn Cardiovasc Imaging 1: 139–147

    Google Scholar 

  14. Moore EH, Greenberg RW, Merrick SH, Miller SW, McLoud TC, Shepard AO (1989) Coronary artery calcifications: significance of incidental detection on CT scans. Radiology 172: 711–716

    Google Scholar 

  15. Masuda Y, Naito S, Aoyagi Y, Yamada Z et al (1990) Coronary artery calcification detected by CT: clinical significance and angiographic correlates. Angiology 41: 1037–1047

    Google Scholar 

  16. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15: 827–832

    Google Scholar 

  17. Tanenbaum SR, Kondos GT, Veselik KE, Prendergast, MR, Brundage BH, Chomka EV (1989) Detection of calcific deposits in coronary arteries by ultrafast computed tomography and correlation with angiography. Am J Cardiol 63: 870–872

    Google Scholar 

  18. Janowitz WR, Agatston AS, Viamonte M (1991) Comparison of serial quantitative evaluation of calcified coronary artery plaque by ultrafast computed tomography in persons with and without obstructive coronary artery disease. Am J Cardiol 68: 1–6

    Google Scholar 

  19. Breen JF, Sheedy PF, Schwartz RS et al (1992) Coronary artery calcification detected with ultrafast CT as as indication of coronary artery disease. Radiology 185: 435–439

    Google Scholar 

  20. Simons DB, Schwartz RS, Edwards WD, Sheedy PF, Breen JF, Rumberger JA (1992) Non-invasive definition of anatomic coronary artery disease by ultrafast computed scanning: a quantitative pathologic comparison study. J Am Coll Cardiol 20: 1118–1126

    Google Scholar 

  21. Stanford W, Thompson BH, Weiss RM (1993) Coronary artery calcification: clinical significance and current methods of detection. AJR 161: 1139–1146

    Google Scholar 

  22. Mautner GC, Mautner SL, Froehlich J et al (1994) Coronary artery calcification: assessment with electron beam CT and histomorphometric correlation. Radiology 192: 619–623

    Google Scholar 

  23. Wong ND, Vo A, Abrahamson D et al (1994) Detection of coronary artery calcium by ultrafast computed tomography and its relation to clinical evidence of coronary artery disease. Am J Cardiol 73: 223–227

    Google Scholar 

  24. Giral P, Filitti V, Levenson J et al (1990) Relation of risk factors for cardiovascular disease to early atherosclerosis detected by ultrasonography in middle-age normotensive hypercholesterolemic men. Atherosclerosis 85: 151–159

    Google Scholar 

  25. Fleiss JL (1986) The design and analysis of clinical experiments. Wiley, New York, pp 1–28

    Google Scholar 

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Correspondence to: P. Challande

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Hernigou, A., Challande, P., Boudeville, J.C. et al. Reproducibility of coronary calcification detection with electron-beam computed tomography. Eur. Radiol. 6, 210–216 (1996). https://doi.org/10.1007/BF00181150

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  • DOI: https://doi.org/10.1007/BF00181150

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