Summary
Despite the increasing use of materials containing bovine collagen in plastic surgery, there is a lack of systemic studies on their immunogenic potential, especially when they are used repeatedly. In this paper, it is shown in rats that the second implantation leads to histologically recognizable cellular reaction, the third to clinical symptoms, and after the fourth, there is a much increased reaction. Oral administration of bovine collagen accelerated and increased the reaction. This also holds true for porcine collagen. Antibodies against collagen could be detected in all groups. These results demonstrate that even lyophilized collagen induced strong immunological reactions, which may also occur in the clinical situation, especially since presensitization by the enteral route cannot be ruled out in most cases. This implies that prior to the repeated use of collagen, studies on the specific reactivity pattern of the patient should be performed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Asghar A, Henrickson RL (1982) Chemical, biochemical, functional and nutritional characteristics of collagen in food systems. Adv Food Res 28:231–372
Becker J (1988) Immunohistochemische Untersuchungen zur strukturellen organisation der extrazellullären Bindegewebsmatrix oraler Hart- and Weichgewebe. Med Habilschrift, Berlin
Butler L, Simmons B, Zimmermann J, DeRiso P, Phadke K (1986) Characteristics of cellular immune responses to collagen type I or collagen type II. Cell Immun 100:314–330
Cederholm B, Wieslander J, Bygren P, Heinegard D (1986) Patients with IgA nephropathy have circulating anti-basement membrane antibodies reacting with structures common to collagen I, II, IV. Proc Natl Acad Sci USA 83:6151–6155
Cooperman LS, Mackinnon V, Bechler G, Pharriss BB (1985) Injectable collagen: a six year clinical investigation. Aesthet Plast Surg 9:145–151
Eberle B (1982) Mechanismem der Immunmanipulation durch enterale Antigenzufuhr. Med Diss-Schrift, München
Gay S, Kresina TF (1982) Immunological disorders of collagen. In: Weiss JP, Hayson MIX (eds) Collagen in health and disease. Churchill Livingstone, Edinburgh, pp 269–288
Halme T, Pelton J, Sims TJ, Vihersaari T, Penttinen R (1986) Collagen in human aorta. Changes in Type 111/1 ratio and concentration of reducible crosslinks, dehydrohydro-lysineonorleucine in ascending aorta from healthy subjects of different age and patients with anulo-aortic ectasia. Biochem Biophys Acta 881:222–228
Kühn K (1985) Structure and biochemistry of collagen. Aesthet Plast Surg 9:141–144
Landsteiner K (1962 Revised Edition) The specificity of serological reactions. Thomas, Springfield, Dover Publications Inc, New York, pp 13–26 (1936)
Maurer PH (1954) Antigenicity of oxypolygelatin and gelatin in man. J Exp Med 100:497–513
Michaeli D, Benjamini E, Leung DYK, Martin GR (1969) Immunochemical studies on collagen. Antigenic differences between guinea pig skin collagen and gelatin. Immunochemistry 8:1–6
Miiller-Ruchholtz W, Wottge HU, Blank M, Anderson M, Muller-Hermelink HK (1984) Chimerism after elimination of immunocompetent cells and their precursors from bone marrow using specified antisera. In: Slavin S (ed) Tolerance in bone marrow and organ transplantation. Elsevier, Amsterdam New York Oxford, pp 198–245
Pierye JM (1985) Collagen injections two years' experience. Aesthet Plast Surg 9:153–154
Schmitt FO, Levin L, Drake MP, Rubin AL, Pfahl O, Davison PIT (1964) The antigenicity of tropocollagen. Proc Natl Acad Sci USA 51:493–497
Seifert J (1978) Enterale Resorption großmolekulärer Proteine bei Menschen and Tieren. Z Ernährungswissensch 18:1–180
Sonntag H-G (1976) Zellartspezifität von Antiseren. Untersuchungen mit Xenoantiseren an Ratten. Thieme, Stuttgart, pp 111–113
Steinmann J (1987) Tierexperimentelle Untersuchungen zur Immunogenität alter and newer Nahrungsmittelproteine. Med Diss-Schrift, Kiel
Timpl R (1976) Immunological studies on collagen. In: Ramachandran GN, Reddi AH (eds) Biochemistry of collagen. Plenum Press, New York, pp 319–375
Timpl R (1984) Immunology of the collagens. In: Piez KA, Reddi AH (eds) Extracellular matrix biochemistry. Elsevier, New York, pp 159–190
Wick G, Olsen BR, Timpl R (1978) Immunohistologic analysis of fetal and dermatosparactic calf and sheep skin collagen with antisera to procollagen and collagen type 1. Lab Invest 39:151–156
Wolff I, Timple R, Pecker I, Steffen C (1967) A two-component system of human serum agglutinating gelatin-coated erythrocytes. Vital Health Stat 2:443–456
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wangerin, K., Wottge, H.U. Immunological reactions against collagen. Eur J Plast Surg 17, 287–291 (1994). https://doi.org/10.1007/BF00181093
Issue Date:
DOI: https://doi.org/10.1007/BF00181093