Abstract
• Background: Since dapiprazole on alpha-adrenergic agent, produces miosis by paralyzing the dilator muscle, and pilocarpine, a parasympathetic drug, causes miosis by affecting the sphincter, we speculated that the two drugs might have additive effects. • Methods: The additive miotic actions of pilocarpine 2% and dapiprazole 0.5% were evaluated by comparing the effects of two drugs given together and alone on the reversal of mydriasis induced by tropicamide (0.5%) and phenylephrine (10%) in one eye each of 60 healthy volunteers. • Results: Dapiprazole and pilocarpine together induced miosis significantly faster than each drug alone, showing additive effects. • Conclusion: Co-administration of dapiprazole and pilocarpine at the end of the eye examination will induce fast pupillary constriction, which might be useful in preventing the development of an acute attack of angle-closure glaucoma in patients with anatomically narrow angles.
This is a preview of subscription content, log in via an institution to check access.
References
Abramson DH, Coleham DJ, Forbs M, Franzen LA (1972) Pilocarpine: effect on the anterior chamber and lens thickness. Arch Ophthalmol 87:615–620
Allinson RW, Gerber DS, Bieber S, Hodes BL (1990) Reversal of mydriasis by dapiprazole. Ann Ophthalmol 22:131–138
Anastasi LM, Ogle KN, Kearns TP (1968) Effect of pilocarpine in counteracting mydriasis. Arch Ophthalmol 79:710–715
Bonomi L, Michieletto S, Marchini G, De Fco J, Valerei P, Silvestrini B (1983) Effects of ocular instillations of dapiprazole on pupil motility. Curr Tber Res 34:469–474
Bonomi L, Morchi G, De Gregorio M (1986) Ultrasonographic study of the ocular effects of topical dapiprazole. Glaucoma 8:30–31
Bucci MG, D'Andrea D, Bettini A, De Gregorio M (1987) Dapiprazole for the reversal of mydriasis due to tropicamide. Glaucoma. 9:94–98
Charles ST, Hamasaki DI (1970) The effect of intraocular pressure on the pupil size. Arch Ophthalmol 83:729–733
Mapstone R (1968) Mechanism of pupil block. Br J Ophthalmol 52:19–25
Mapstone R (1976) Provocative test in closed angle glaucoma. Br J Ophthalmol 60:115–119
Nelson ME, Orton HP (1987) Counteracting the effects of mydriatics. Arch Ophthalmol 105:486–489
Reibaldi A (1984) A new alpha blocking agent. Glaucoma 3:255–257
Rotkowski PC, Fernandez JL, Galin MA, Halasa AH (1973) Alpha-adrenergic receptor blockade in the treatment of angle-closure glaucoma. Trans Am Acad Ophthalmol Otolaryngol 77:137
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Geyer, O., Loewenstein, A., Shalmon, B. et al. The additive miotic effects of dapiprazole and pilocarpine. Graefe's Arch Clin Exp Ophthalmol 233, 448–451 (1995). https://doi.org/10.1007/BF00180951
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00180951