Abstract
Experimental neogut production was achieved in dogs. After 90% enterectomy, an artificial opening on the antimesenteric border of the intestinal remnant was patched with lyophilized human dura. The internal surface of the patch was completely covered by neomucosa within 8 weeks. Histological and morphometric studies showed that the structure of the newly formed mucosa was similar to that of the neighboring mucosa. The submucosal tunica muscularis started regenerating after the 14th week post-patching. Enterization of the dural patch contributes positively to the management of small bowel syndrome (SBS), as evidenced by an increase in body weight. This increase is highly significant statistically (P < 0.001) in the animals with dural patch as compared to control animals. The slower transit time of intestinal contents after patching and the compensatory adaptive processes also result in increasing body weight.
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Pappis, C.H., Kaïris, M.Z. & Willital, G.H. Enterization of the dural patch. Pediatr Surg Int 1, 192–196 (1986). https://doi.org/10.1007/BF00180923
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DOI: https://doi.org/10.1007/BF00180923