Cardiac involvement during and after malaria

Summary

In 22 patients without a previous history of cardiac disease, we prospectively evaluated cardiac involvement during acute malaria and 9±5 months after recovery using non-invasive methods including resting electrocardiogram (ECG) and two-dimensional (2D) echocardiography. During the acute phase ECG abnormalities were common (5/22); pericardial effusion was found in 2 patients and global left ventricular hypokinesia in 1 patient infected with Plasmodium falciparum. At a follow-up of 19 patients, the resting ECG and echocardiography were normal or had normalized in all patients. The results of our study suggest that persistent cardiac damage following malarial infection seems to be rare; however, further trials in a larger patient population are needed to confirm our findings.

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Abbreviations

PE:

pericardial effusion

LV:

left ventricular depression

C:

chloroquine

M:

mefloquine

P:

primaquine

F:

fansidar

Q:

quinine

ECG:

electrocardiogram

2D:

two-dimensional

LVEDD:

left ventricular end-diastolic dimension (mm)

FS:

fractional shortening (%)

LV:

left ventricular

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Additional information

Preliminary data have been presented at the Tagung der Deutschen Gesellschaft für Innere Medizin in Wiesbaden, FRG, April 6–10, 1991 [KIin Wochenschr (1991) 69 [Suppl 23]:448]

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Franzen, D., Curtius, J.M., Heitz, W. et al. Cardiac involvement during and after malaria. Clin Investig 70, 670–673 (1992). https://doi.org/10.1007/BF00180283

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Key words

  • Malaria
  • Cardiac abnormality