The clinical investigator

, Volume 70, Issue 8, pp 670–673 | Cite as

Cardiac involvement during and after malaria

  • D. Franzen
  • J. M. Curtius
  • W. Heitz
  • H. W. Höpp
  • V. Diehl
  • H. H. Hilger
Original Article

Summary

In 22 patients without a previous history of cardiac disease, we prospectively evaluated cardiac involvement during acute malaria and 9±5 months after recovery using non-invasive methods including resting electrocardiogram (ECG) and two-dimensional (2D) echocardiography. During the acute phase ECG abnormalities were common (5/22); pericardial effusion was found in 2 patients and global left ventricular hypokinesia in 1 patient infected with Plasmodium falciparum. At a follow-up of 19 patients, the resting ECG and echocardiography were normal or had normalized in all patients. The results of our study suggest that persistent cardiac damage following malarial infection seems to be rare; however, further trials in a larger patient population are needed to confirm our findings.

Key words

Malaria Cardiac abnormality 

Abbreviations

PE

pericardial effusion

LV

left ventricular depression

C

chloroquine

M

mefloquine

P

primaquine

F

fansidar

Q

quinine

ECG

electrocardiogram

2D

two-dimensional

LVEDD

left ventricular end-diastolic dimension (mm)

FS

fractional shortening (%)

LV

left ventricular

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • D. Franzen
    • 1
  • J. M. Curtius
    • 1
  • W. Heitz
    • 1
  • H. W. Höpp
    • 1
  • V. Diehl
    • 1
  • H. H. Hilger
    • 1
  1. 1.Kliniken I und III für Innere Medizin der Universität zu KölnKöln 41Germany

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