Summary
To pregnant or breast feeding women drugs should be given with caution. We report the case of a 5-week-old breast-fed infant whose mother was taking 300 mg allopurinol/day for 4 weeks. Allopurinol and oxypurinol were detected by HPLC in maternal plasma and breast milk with a method first described here. In infant's plasma taken 2 h after breast feeding oxypurinol was found; allopurinol was below the limit of detection. The milk/plasma ratio in the mother 2 h (4 h) after drug ingestion was 0.9 (1.4) for allopurinol and 3.9 (2.4) for oxypurinol. The average daily dose for the baby of allopurinol was 0.14–0.20 mg/kg and that of oxypurinol 7.2–8.0 mg/kg by ingestion of breast milk after oral intake of allopurinol by the mother.
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Dedicated to Prof. Dr. N. Zöllner on the occasion of his 70th birthday
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Kamilli, I., Gresser, U. Allopurinol and oxypurinol in human breast milk. Clin Investig 71, 161–164 (1993). https://doi.org/10.1007/BF00179999
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DOI: https://doi.org/10.1007/BF00179999