Abstract
Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1–16 mg/kg) and progesterone (10–80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased responding. Sex differences were observed in the rate-decreasing effects of high doses of pentobarbital. Progesterone increased the response rate of ovariectomized females, but did not affect responding in intact males.
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Heinsbroek, R.P.W., van Haaren, F., Zantvoord, F. et al. Effects of pentobarbital and progesterone on random ratio responding in male and female rats. Psychopharmacology 93, 178–181 (1987). https://doi.org/10.1007/BF00179930
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DOI: https://doi.org/10.1007/BF00179930