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Bone morphogenetic protein: a review

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Summary

The osteogenic potential of bone and bone matrix has been characterised only by its biological effects and the parameters influencing it. Recently, the osteoinductive ability of bone matrix had been defined chemically by the description of a bone morphogenetic protein (BMP), and the parameters of osteogenic factors from different species have now been recognised. The current state of isolation, purification and characterisation of these factors is summarised in this review. General aspects of the isolation and testing of BMP preparations, and the results of orthotopic application of BMP implants, including clinical cases, are reported.

Résumé

Le potentiel ostéogénique de l'os et de la matrice osseuse a été longtemps caractérisé uniquement par ses effets biologiques et les paramètres qui l'influencent. Récemment la capacité ostéo-inductrice de la matrice osseuse a été définie chimiquement par l'identification d'une protéine osseuse morphogènétique (POM) et des facteurs ostéogéniques de différents types ont été individualisés. L'état actuel de l'isolement, de la purification, et de la caractérisation de ces facteurs est résumé dans cette mise au point. On y rapporte les aspects généraux de l'isolement et de l'appréciation des préparations de POM ainsi que les résultats de l'application d'implants de POM, y compris en clinique.

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Authors and Affiliations

  1. Orthopaedic Hospital Paulinenhilfe, Forststrasse 14, W-7000, Stuttgart, Germany

    G. Aldinger

  2. Orthopaedic University Clinic, University of Tübingen, Hoppe-Seyler-Strasse 3, W-7400, Tübingen, Germany

    G. Herr, W. Küsswetter & H. J. Reis

  3. Department of Trauma and Reconstructive Surgery, Katharinenhospital, W-7000, Stuttgart, Germany

    F. W. Thielemann & U. Holz

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  1. G. Aldinger
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  2. G. Herr
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Aldinger, G., Herr, G., Küsswetter, W. et al. Bone morphogenetic protein: a review. International Orthopaedics 15, 169–177 (1991). https://doi.org/10.1007/BF00179720

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