Summary
Liquefactive necrosis coexistent with alteration of vascular permeability was studied following electrical stimulation of the spinal cord. Evans blue albumen complex (EBA) (2.5%) was perfused one hour before electrical stimulation for 30 min with 10 mA current of 0.3 msec duration at a frequency of 20 Hz. Perfusion with saline and formalin was carried out at 0, 1, 3, 6 and 12 h after stimulation had been completed. Results were independent of the time lapse after completion of the stimulation. Liquefactive necrosis, swelling and moniliform degeneration and myelinoclasia of the myelin sheath were noted only in the external layer of the white matter. EBA leakage occurred, but there was no further expansion with time.
Résumé
Les auteurs ont étudié, après stimulation électrique de la moelle épinière, la nécrose liquéfiante avec altération de la perméabilité vasculaire. Un complexe (2.5%) d'albumine et de bleu Evans (ABE) a été perfusé une heure avant une stimulation électrique de 30 minutes par un courant de 10 mA, de 0.3 msec de durée, à une fréquence de 20 Hz. Une perfusion de sérum salé et de formaline a été effectuée 1, 2, 6 et 12 heures après que la stimulation ait été terminée. Les résultats sont indépendants du délai écoulé depuis la fin de la stimulation. On observe, au niveau seulement de la couche externe de la substance blanche, une nécrose liquéfiante, un oedème et une dégénérescence moniliforme, une myélinoclasie des gaînes des myéline. Une fuite de l'ABE s'est produite, mais elle n'augmente pas avec le temps.
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Takakuwa, K., Tsuji, H., Takano, H. et al. Delayed changes of vascular permeability in the cat's spinal cord following continuous electrical stimulation. International Orthopaedics 15, 123–126 (1991). https://doi.org/10.1007/BF00179710
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DOI: https://doi.org/10.1007/BF00179710