Abstract
Necrotizing enterocolitis (NEC) is the pre-eminent gastrointestinal disorder encountered among stressed premature infants in neonatal intensive care units. Thirty-one sporadic cases of gastroenteritis occured in children between the ages of 48 days and 24 months who presented with varying degrees of septicemia, hypovolemic shock, hypotension, metabolic acidosis, and disseminated intravascular coagulation. These patients developed clinical features and radiologic signs characteristic of neonatal NEC. The occurence of NEC in children as a sequel to gastroenteritis and its etiology, pathogenesis, clinical features, laboratory data, radiologic findings, and outcome are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Arseculeratne SN, Panabokke RG, Navaratnam C (1980) Pathogenesis of necrotizing enteritis with special reference to intestinal hypersensitivity reactions. Gut 21: 265–278
Butler T, Dahms B, Lindpainter K, et al (1987) Segmental necrotizing enterocolitis: pathological and clinical features of 22 cases in Bangladesh. Gut 28: 1433–1438
Bynum TE, Jacobson ED (1979) Nonocclusive intestinal ischemia. Arch Intern Med 139: 281–282
Caplan MS, Hsueh W (1990) Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor. J Pediatr 11: 47–51
Denizot Y, Dassa E, Benveniste J, et al (1989) Paf-acether production by Escherichia coli. Biochem Biophys Res Commun 161: 939–943
Denizot Y, Dassa E, Kim HY, et al. (1989) Synthesis of paf-acether from exogenous precursors by the prokaryote Escherichia coli. FEBS Lett 243: 13–16
Fasching G, Hollwarth ME, Schmidt B, et al. (1992) Necrotizing enterocolitis in very-low-birth-weight infants. Pediatr Surg Int 7: 428–430
Hsueh W, Caplan MS, Sun X, et al. (1992) Pathogenetic lessons from experimental models of necrotizing enterocolitis. Pediatr Surg Int 7: 415–420
Kalani BP, Shekhawat NS, Sogani KC (1985) Acute segmental necrotizing enteritis in children. Am J Dis Child 139: 586–588
Kliegman RM (1979) Neonatal necrotizing enterocolitis: implication for an infectious disease. Pediatr Clin North Am 26: 327–344
Kliegman RM (1990) Models of the pathogenesis of necrotizing enterocolitis. J Pediatr 117: 2–5
Lawerence G, Shann F, Freestone DS, et al (1979) Prevention of necrotizing enteritis in Papua New Guinea by active immunization. Lancet 1: 227–230
Murrell TGC, Roth L, Egerton J, et al (1966) Pig-bel: enteritis necroticans—a study in diagnosis and management. Lancet 1: 217–222
Palmer S, Biffen A, Gamsu H (1989) Outcome of neonatal necrotizing enterocolitis: results of the BAPM/CDSC surveillance study 1981–84. Arch Dis Child 64: 388–394
Polin RA, Pollack PF, Barlow B, et al (1976) Necrotizing enterocolitis in term infants. J Pediatr 89: 460–462
Spenger KJ, Kaschula ROC, Nicholson N (1987) Necrotizing enterocolitis after the neonatal period. J Trop Pediatr 33: 233–238
Takayanagi K, Kapila L (1981) Necrotizing enterocolitis in older infants. Arch Dis Child 56: 468–471
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Samuel, M., Sajwany, M.J. Necrotizing enterocolitis in children between the ages of 48 days and 24 months. Pediatr Surg Int 9, 564–566 (1994). https://doi.org/10.1007/BF00179682
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00179682