Abstract
Forty-two patients were entered into a phase I trial to evaluate the vitamin A derivative, trans-retinoic acid, in cervical intraepithelial neoplasia. Treatment consisted of four consecutive 24-h applications of retinoids via an inert collagen sponge in a cervical cap. Patients were followed for response at 3-month intervals using cytology, colposcopy, and selected biopsies. Thirty-six patients were evaluable (mild dysplasia, 13; moderate dysplasia, 17; severe dysplasia, 6) with follow-up from 5 to 18 months. Complete regression was seen in 2/14 (14%) patients treated with concentrations of 0.05% → 0.1167% and in 10/22 (45%) patients treated with concentrations of 0.1583% → 0.484% (p < 0.05). One patient with negative biopsies at 12 months has subsequently recurred at 18 months.
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References
Lotan R: Effect of vitamin A and its analogues (retinoids) in normal and neoplastic cells. Biochem Biophy Acta 605:33, 1980
Peck GL: Chemoprevention of cancer with retinoids. Gynecol Oncol 12:5331, 1981
Surwit EA, Graham V, Droegemueller W, Alberts D, Chvapil M, Dorr R, Davis J, Meyskens F: Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraephithelial lesions. Am J Obstet Gynecol 143:821, 1982
Meyskens FL, Graham V, Chvapil M, Dorr R, Alberts DS, Surwit EA: A phase I trial of B-all-trans-retinoic acid delivered via a collagen sponge and cervical cap for mild or moderate intraephithelial cervical neoplasia. JNCI 71:921–925, 1983
Chvapil M: Collagen Sponge: Theory and practice of medical applications. J Biomed Mater Res 11:721–726, 1977
Kummet T, Meyskens FL: Vitamin A: A potential inhibitor of human cancer. Semin Oncol X:281–9, 1983
Chu EW, Malmgren RA: An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons. Cancer Res 25:884–885, 1965
Lutzner MH, Blanchet-Bardon C: Oral retinoid treatment of human papilloma virus type 5-induced epidermolyplasia verruciformis. New Engl J Med 302:1091, 1980
Reid R: Genital warts and cervical cancer II: Is human papilloma virus infection the trigger to cervical carcinogenesis? Gynecol Oncol 15:239–252, 1983
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Weiner, S.A., Surwit, E.A., Graham, V.E. et al. A phase I trial of topically applied trans-retinoic acid in cervical dysplasia-clinical efficacy. Invest New Drugs 4, 241–244 (1986). https://doi.org/10.1007/BF00179590
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DOI: https://doi.org/10.1007/BF00179590