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A polymorphic dinucleotide repeat in the human IL-10 promoter

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References

  • Cush, J. C., Splawski, J. B., Thomas, R., McFarlin, J. E., Schulze-Koops, H., Davis, L. S., Fujita, K., and Lipsky, P. E. Elevated levels of interleukin-10 in patients with rheumatoid athritis. Arth Rheum 38: 96–104, 1995

    Google Scholar 

  • Fiorentino, D. F., Zlotnic, A., Viera, P., Mosmann, T. R., Howard, M., Moore, K. W., and O'Garra, A. IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146: 3444–3451, 1991

    Google Scholar 

  • Kube, D., Platzer, C., von, Knethen, A., Straub, H., Bohlen, H., Hafner, M., and Tesch, H. Isolation of the human interleukin 10 promoter. Characterisation of the promoter activity in Burkitts's lymphoma cell lines. Cytokine 7: 1–7, 1995

    Article  CAS  PubMed  Google Scholar 

  • Luscher, U., Filgueira, L., Juretic, A., Zuber, M., Luscher, N. J., Heberer, M., and Spagnoli, G. C. The pattern of cytotokine gene expression in freshly excised human metastatic melonoma suggests a state of reversible anergy of tumour infiltrating lymphocyres. Int J Cancer 57: 612–619, 1994

    Google Scholar 

  • Marsh, D. G., Neely, J. D., Breazeale, D. R., Ghosh, B., Freidhoff, L. R., Ehrlich-Kautzky, E., Schou, C., Krishnaswamy, G., and Beaty, T. Linkage analysis of IL_4 and other chromosome 5q31.1 markers and total serum immunoglobulin concentrations. Science 264: 1152–1156, 1994

    Google Scholar 

  • Moore, K. W., O'Garra, A., de Waal-Malefyt, R., Viera, P., and Mosmann, T. R. IL-10. Annu Rev Immunol 11: 165–290, 1993

    Google Scholar 

  • Pociot, F., Briant, L., Jongeneel, C. V., Molvig, J., Worsaae, H., Abbal, M., Thomsen, M., Nerup, J., and Cambon-Thomsen, A. Association of tumour necrosis factor (TNF) and class II major histocompatibility complexc alleles with the secretion of TNF-α and TNF-β by human mononucleat cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol 23: 224–231, 1993

    CAS  PubMed  Google Scholar 

  • Udalova, I. A., Nedospasov, S. A., Webb, G. C., Chaplin, D. D., and Terutskaya, R. L. Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics 16: 180–186, 1993

    Google Scholar 

  • Wanidworanum, C. and Strober, W. Predominant role of tumour necrosis factor-α in human monocyte IL-10 synthesis. J Immunol 151: 6853–6861, 1993

    Google Scholar 

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The polymorphism data reported in this paper have been submitted to the Human Genome databse and have been assigned the accession number G00-603-930

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Eskdale, J., Gallagher, G. A polymorphic dinucleotide repeat in the human IL-10 promoter. Immunogenetics 42, 444–445 (1995). https://doi.org/10.1007/BF00179416

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  • DOI: https://doi.org/10.1007/BF00179416

Keywords

  • Dinucleotide
  • Dinucleotide Repeat
  • Polymorphic Dinucleotide
  • Polymorphic Dinucleotide Repeat