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Behavioral effects of adenosine analogs in squirrel monkeys: relation to adenosine A2 receptors

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Abstract

The behavioral effects of seven metabolically stable analogs of adenosine were studied in squirrel monkeys responding under a fixed-interval (FI) schedule of stimulus-shock termination. All drugs produced dose-related decreases in response rate, but differed in potency by up to three orders of magnitude. The 5′-carboxamine and 2-chlorine substituted analogs were more potent than the N6-substituted analogs. The potencies of the adenosine analogs in decreasing schedule-controlled behavior correlate well with their reported affinities for adenosine A2, but not A1, recognition sites as determined by displacement of bound ligands or modulation of adenylate cyclase activity. The results suggest that the behavioral effects of adenosine analogs in squirrel monkeys are linked to their actions at adenosine A2 receptors.

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Authors and Affiliations

  1. Harvard Medical School, New England Regional Primate Research Center, 01772, Southborough, MA, USA

    R. D. Spealman & V. L. Coffin

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  1. R. D. Spealman
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  2. V. L. Coffin
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Animals used in this study were maintained in accordance with the guidelines of the Committee on Animals of the Harvard Medical School and of the “Guide for Care and Use of Laboratory Animals” of the Institute of Laboratory Animal Resources, National Research Council, Department of Health, Education and Welfare, Publication No. (NIH)85-23, revised 1985

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Spealman, R.D., Coffin, V.L. Behavioral effects of adenosine analogs in squirrel monkeys: relation to adenosine A2 receptors. Psychopharmacology 90, 419–421 (1986). https://doi.org/10.1007/BF00179203

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  • DOI: https://doi.org/10.1007/BF00179203

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