Abstract
The effects of an intraveneous infusion of physostigmine (0.94 mg infused over 60 min) on performance in memory tests were studied in 12 young subjects. Drug effects were modest and are discussed in relation to results of physostigmine studies in Alzheimer patients.
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References
Andersson K, Hockey GRJ (1977) Effects of cigarette smoking on incidental memory. Psychopharmacology 52:223–226
Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408–417
Beller SA Overall JE, Swann AC (1985) Efficacy of oral physostigmine in primary degenerative dementia. Psychopharmacology 87:147–151
Davis KL, Mohs RC, Tinklenberg JR, Pjefferbaum A, Hollister LE, Kopell BS (1978) Physostigmine: Improvement of long-term memory processes in normal subjects. Science 201:272–274
Drachman DA, Leavitt J (1974) Human memory and the cholinergic system. Arch Neurol 30:113–121
Drachman DA, Sahakian BJ (1980) Memory and cognitive function in the elderly: a preliminary trial of physostigmine. Arch Neurol 37:674–675
Dunne MP, Hartley LR (1985) The effects of scopolamine upon verbal memory: Evidence for an attentional hypothesis. Acta Psychol 58(3):205–217
Ghoneim MM, Mewaldt SP (1977) Studies in human memory: The interactions of diazepam, scopolamine and physostigmine. Psychopharmacology 52:1–6
Goodman Gilman A, Goodman LS, Gilman A (1980) The pharmacological basis of therapeutics. Macmillan, New York
Petersen RC (1977) Scopolamine induced learning failures in man. Psychopharmacology 52:283–289
Smith CM, Swash M (1978) Possible biochemical basis of memory disorder in Alzheimer's disease. Ann Neurol 3:471–473
Smith CM, Semple CA, Swash M (1982) Effects of physostigmine on responses in memory tests in patients with Alzheimer's disease. In: Corkin S, Davis KL, Growdon JH, Usdin E, Wurtman RJ (eds) Alzheimer's disease. Review of progress. Aging, Vol. 19, Raven Press, New York, pp 403–409
Thal LJ, Masur MS, Sharpless NS, Fuld PA, Davies P (1984) Acute and chronic effects of oral physostigmine and lecithin in Alzheimer's disease. In: Wurtman RJ, Corkin SH, Growdon JH (eds) Alzheimer's disease: advances in basic research and therapies. Center for Brain Sciences and Metabolism Charitable Trust
Thorndike EL, Lorge I (1944) The Teacher's Word Book of 30,000 words. Columbia University Press, New York
Warburton DM, Wesnes K (1984) Drugs as research tools in psychology: Cholinergic drugs and information processing. Neuropsychobiology 11:121–132
Whelpton R (1983) Analysis of plasma physostigmine concentrations by liquid chromatography. J Chromatog 272:216–220
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Smith, C.M., Coogan, J.S. & Hart, S. Effects of physostigmine on memory test performance in normal volunteers. Psychopharmacology 90, 364–366 (1986). https://doi.org/10.1007/BF00179192
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DOI: https://doi.org/10.1007/BF00179192