Summary
Three patients with the chief complaints of dizziness while standing up or blackouts were diagnosed correctly as having the Shy-Drager syndrome at the Department of Otolaryngology. Both the electrocardiogram R-peak to R-peak interval and the Schellong test revealed disorders of the autonomic nervous system in each of these cases. Electronystagmography also demonstrated pathology of the oculomotor system and/or central vestibular system. Postural balance was also abnormal in one of the cases. Auditory brain-stem responses were normal in all three cases.
Similar content being viewed by others
References
Adams RD, Salam-Adams M (1986) Striatonigral degeneration. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol 49. Extrapyramidal disorders. Elsevier, Amsterdam, pp 205–211
Barbeau A (1986) Parkinson's disease: clinical features and etiopathology. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol. 49. Extrapyramidal disorders. Elsevier, Amsterdam, pp 87–109
Barr AN (1986) The Shy-Drager syndrome. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol. 38. Neurologial manifestations of systemic diseases part I. Elsevier, Amsterdam, pp 233–253
Coccagna G, Martinelli P, Zucconi M, Cirignotta F, Amborosetto G (1985) Sleep related respiratory and haemodynamic changes in Shy-Drager syndrome: a case report. J Neurol 232: 310–313
Ewing DJ, Campbell IW, Murray A, Neilson JMN, Clarke BF (1978) Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes. Br Med J 21:145–147
Honda K, Nose T, Yoshida N, Tanimura M, Tanaka K (1977) Responses to the postural change and orthostatic dysregulation symptoms. Jpn Circ J 41: 629–641
Kachi T, Iwasa S, Mano T, Saito M, Kunimoto M, Sobue I (1988) Effect of l-threo-3,4-dihydroxyphenylserine on muscle sympathetic nerve activities in Shy-Drager syndrome. Neurology 38:1091–1094
Kennedy PGE, Duchen LW (1985) A quantitative study of intermediolateral column cells in motor neuron disease and the ShyDrager syndrome. J Neurol Neurosurg Psychiatry 48:1103–1106
Martinovits G, Leventon G, Goldhammer Y, Sadeh M (1988) Vocal cord paralysis as a presenting sign in the Shy-Drager syndrome. J Laryngol Otol 102:280–281
Meyer JS, Shimazu K, Fukuuchi Y, Ohuchi T, Okamoto S, Koto A, Ericsson AD (1973) Cerebral dysautoregulation in central neurogenic orthostatic hypotension (Shy-Drager syndrome). Neurology 23:262–273
Ohashi N, Kanda K, Shoujaku H, Ohi H, Watanabe Y, Mizukoshi K (1986) Equilibrium disorders and R-R intervals in ECG. Auris Nasus Larynx 13 [Suppl II]: 193–197
Pastakia B, Polinsky R, Di Chiro G, Simmons JT, Brown R, Wener L (1986) Multiple system atrophy (Shy-Drager syndrome): MR imaging. Radiology 159:499–502
Prasher D, Bannister R (1986) Brain stem auditory evoked potentials in patients with multiple system atrophy with progressive autonomic failure (Shy-Drager syndrome). J Neurol Neurosurg Psychiatry 49:278–289
Sakoda S, Suzuki T, Higa S, Ueji M, Kishimoto S, Matsumoto M, Yoneda S (1985) Treatment of orthostatic hypotension in Shy-Drager syndrome with DL-threo-3,4-dihydroxyphenyl-serine: a case report. Eur Neurol 24:330–334
Schatz I (1984) Orthostatic hypotension: diagnosis and treatment. Hosp Pract 4:59–69
Schellong F (1954) Regulationsprüfung des Kreislaufes. Steinkopff, Darmstadt
Sima AAF, Hoag G, Rozdilskyt G (1977) Shy-Drager syndrome: the transitional variant. Clin Neuropathol 16:49–54
Tanimura M, Honda K, Nose T, Tanaka K, Yoshida N (1977) Reproducibility of the orthostatic responses and orthostatic dysregulation complaints in Japanese junior and senior high school students. Jpn Circ J 41:287–298
Vereecken RL, Goovaerts J, Knockaert D, Joossens J, Sansen W (1985) Urological aspects of the Shy-Drager syndrome: a urodynamic and telemetric investigation. Eur Urol 11:65–68
Wheeler JS Jr, Canning JR (1985) Voiding dysfunction in ShyDrager syndrome. J Urol 134:362–363
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohashi, N., Nakagawa, H., Kanda, K. et al. Otoneurological manifestations of the Shy-Drager syndrome. Eur Arch Otorhinolaryngol 248, 150–152 (1991). https://doi.org/10.1007/BF00178926
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00178926